Sudden Infant Death Syndrome

Also see categories hypotonic-hyporesponsive episodes and cardiorespiratory

Adverse events following Haemophilus influenzae type b vaccines in the Vaccine Adverse Event Reporting System, 1990-2013.

“Includes 29 747 reports after Hib vaccines; 5179 (17%) were serious, including 896 reports of deaths. Median age was 6 months (range 0-1022 months). Sudden infant death syndrome was the stated cause of death in 384 (51%) of 749 death reports with autopsy/death certificate records.”

#SIDS #Death #Sudden #Infant #Death #Syndrome #Hib #VAERS #Gastrointestinal #Neurological #Vaccine #MedScienceResearch

๐Ÿ›‘ Beta-tryptase and quantitative mast-cell increase in a sudden infant death following hexavalent immunization.

“A fatal case of a 3-month-old female infant, who died within 24 h of vaccination with hexavalent vaccine is presented. Clinical data, post-mortem findings (acute pulmonary oedema, acute pulmonary emphysema), quali-quantitative data collected from immunohistochemical staining (degranulating mast cells) and laboratory analysis with a high level of beta-tryptase in serum, 43.3 microg/l, allows us to conclude that acute respiratory failure likely due to post hexavalent immunization-related shock was the cause of death.”

#Sudden #Infant #Death #Syndrome #Vaccine #SIDS #Hexavalent #Respiratory

๐Ÿ›‘ [Complications of pertussis immunization (author transl)].

“16 cases of neurological disease and/or death shortly after pertussis immunization are reported. Eight patients had convulsions, six with ensuing permanent defects. Severe polymyositis was observed in one case. Five infants died 12 h to 4 days after vaccination: two after acute encephalopathy and three in the form of a sudden unexpected death (SID). In two fatal cases the morphological changes in the brain corresponded to those of pertussis encephalopathy: neuronal degeneration in various parts of the cortex, especially in the region of the ammons horn, and in the cerebellum. There were no signs of inflammation. Three cases underwent forensic autopsy and death was attributed to bronchopulmonary infection. Complete neuropathological work-up was only done in one case, in which the brain was normal. The critique of episodical reports and the demand for prospective studies is appreciated. Knowledge of all possible forms of complications, however, is indispensable for future investigations. Polymyositis and SID have so far not been listed as abnormal reactions to immunization. The majority of our cases became known accidentally from hospital sheets or from discussions with collegues. For a detection of all possible cases a greater awareness of doctors for the problem of pertussis immunization appears necessary. Only another 23 cases have been reported to the health authorities of the state of Lower Saxony during the last 6 to 7 years. Of those, nine were either harmless reactions or diseases probably unrelated to vaccination. Two were cases of SID, 12 and 72 h after vaccination. It is concluded that only a minor proportion of possible complications is presently reported to the health authorities.”

#Sudden #Infant #Death #Syndrome #SIDS #Pertussis #Neurological #Seizures #Encephalopathy
#Musculoskeletal #Respiratory #Vaccine #MedScienceResearch

Deaths Reported to the Vaccine Adverse Event Reporting System, United States, 1997-2013.

“RESULTS: VAERS received 2149 death reports, most (n = 1469 [68.4%]) in children. Median age was 0.5 years (range, 0-100 years); males accounted for 1226 (57%) reports. The total annual number of death reports generally decreased during the latter part of the study period. Most common causes of death among 1244 child reports with available death certificates/autopsy reports included sudden infant death syndrome (n = 544 [44%]), asphyxia (n = 74 [6.0%]), septicemia (n = 61 [4.9%]), and pneumonia (n = 57 [4.6%]). Among 526 adult reports, most common causes of death included diseases of the circulatory (n = 247 [46.9%]) and respiratory systems (n = 77 [14.6%]), certain infections and parasitic diseases (n = 62 [11.8%]), and malignant neoplasms (n = 20 [3.8%]). For child death reports, 79.4% received >1 vaccine on the same day. Inactivated influenza vaccine given alone was most commonly associated with death reports in adults (51.4%).”

#Death #SIDS #Vaccines #Flu #Influenza #VAERS #Respiratory

The epidemiology of fatalities reported to the vaccine adverse event reporting system 1990-1997.

“RESULTS: A total of 1266 fatalities were reported to VAERS during July 1990 through June 1997. The number of death reports peaked in 1992-1993 and then declined. The overall median age of cases was 0.4 years, with a range of 1 day to 104 years. Nearly half of the deaths were attributed to sudden infant death syndrome (SIDS).”

#SIDS #Death #Vaccine #VAERS #MedScienceResearch

๐Ÿ›‘ Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

“After reviewing the literature, we observed that complications seen after Hepatitis B vaccination are sudden infant death syndrome, multiple sclerosis, chronic fatigue syndrome, idiopathic thrombocytopenic purpura, vasculititis optic neuritis, anaphylaxis, systemic lupus erytymatosus, lichen planus and neuro-muscular disorder.”

#Sudden #Infant #Death #Syndrome #SIDS #Hepatitis B #Multiple #Sclerosis #Neurological #Chronic #Fatigue #Syndrome #Lupus #Dermatological #Anaphylaxis #Ophthalmological
#Vaccine #MedScienceResearch

Infant mortality rates regressed against number of vaccine doses routinely given: Is there a biochemical or synergistic toxicity?

#SIDS #Death #Vaccine #Sudden #Infant #Death #Syndrome #MedScienceResearch

๐Ÿ›‘ Neonatal deaths after hepatitis B vaccine: the vaccine adverse event reporting system, 1991-1998.

“RESULTS: Of 1771 neonatal reports, there were 18 deaths in 8 boys and 9 girls (1 patient unclassified). The mean age at vaccination for these 18 cases was 12 days (range, 1-27 days); median time from vaccination to onset of symptoms was 2 days (range, 0-20 days); and median time from symptoms to death was 0 days (range, 0-15 days). The mean birth weight of the neonates (n = 15) was 3034 g (range, 1828-4678 g). The causes of death for the 17 autopsied cases were sudden infant death syndrome for 12, infection for 3, and 1 case each of intracerebral hemorrhage, accidental suffocation, and congenital heart disease.”

#Sudden #Infant #Death #Syndrome #SIDS #Hepatitis B
#Vaccine #MedScienceResearch

Preparation for global introduction of inactivated poliovirus vaccine: safety evidence from the US Vaccine Adverse Event Reporting System, 2000-12.

“Of the 41,792 adverse event reports submitted, 39,568 (95%) were for children younger than 7 years. 38,381 of the reports for children in this age group (97%) were for simultaneous vaccination with IPV and other vaccines (most commonly pneumococcal and acellular pertussis vaccines), whereas standalone IPV vaccines accounted for 0ยท5% of all reports. 34,880 reports were for non-serious events (88%), 3905 reports were for non-fatal serious events (10%), and 783 reports were death reports (2%). Injection-site erythema was the most commonly coded term for non-serious events (29%), and pyrexia for non-fatal serious events (38%). Most deaths (96%) were in children aged 12 months or younger; most (52%) had sudden infant death syndrome as the reported cause of death.”

#SIDS #Sudden #Infant #Death #Polio #Pneumococcal #DTaP #MedScienceResearch #Vaccine

Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010.

“…cases that specified either hospitalization or death were identified among 38,801 reports of infants.”

“Our findings show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths.”

#SIDS #Death #Vaccine #MedScienceResearch

Revisiting the possibility of serious adverse events from the whole cell pertussis vaccine: were metabolically vulnerable children at risk?

“In the early 1980’s concerns about the safety of the whole cell pertussis vaccine in the United States resulted in declining vaccination rates and the withdrawal of multiple vaccine providers from the market. While the possibility of inflammation and febrile reactions to the vaccine were acknowledged by public health authorities, parents also claimed the vaccine was associated with sudden infant death syndrome and encephalopathy. Epidemiological studies examining this question, however, consistently failed to identify an association. We argue that these reactions may have occurred in metabolically vulnerable children, specifically those with defects in fatty acid oxidation. In these children the combination of anorexia and fever that could be caused by the vaccine may have resulted in hypoglycemic episodes and possibly death. We believe that this association was not detected because these conditions were not recognized at the time and because these conditions are uncommon. Nevertheless, at a population level, enough events could have occurred to cause concern amongst parents.”

#SIDS #Sudden #Infant #Death #DTP #Encephalopathy #Hypoglycemia #Pertussis #Vaccine #MedScienceResearch

Simultaneous sudden infant death syndrome.

#SIDS #DTP #Polio #Hepatitis B #MedScienceResearch #Vaccine

Sudden and unexpected deaths after the administration of hexavalent vaccines (diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, Haemophilius influenzae type b): is there a signal?

#SIDS #Death #Hexavalent #Vaccine #MedScienceResearch

Sudden infant death following hexavalent vaccination: a neuropathologic study.

#SIDS #Hexavalent #Vaccine #MedScienceResearch #Death

๐Ÿ›‘ Sudden infant death syndrome (SIDS) shortly after hexavalent vaccination: another pathology in suspected SIDS?

“Herein we report the case of a 3-month-old female infant dying suddenly and unexpectedly shortly after being given a hexavalent vaccination. Examination of the brainstem on serial sections revealed bilateral hypoplasia of the arcuate nucleus. The cardiac conduction system presented persistent fetal dispersion and resorptive degeneration. This case offers a unique insight into the possible role of hexavalent vaccine in triggering a lethal outcome in a vulnerable baby. Any case of sudden unexpected death occurring perinatally and in infancy, especially soon after a vaccination, should always undergo a full necropsy study according to our guidelines.”

#Sudden #Infant #Death #Syndrome #Vaccine #SIDS #Hexavalent #MedScienceResearch

Vaccination and unexplained sudden death risk in Taiwanese infants.

“In March 1992, eight infants who had died within 36 hours of receiving whole-cell pertussis vaccine (diphtheria, tetanus, and whole-cell pertussis [DTwP]) prompted the Taiwan health authorities to suspend its use.”

#SIDS #Death #DTP #Vaccine #MedScienceResearch

Vaccination with 10-valent pneumococcal conjugate vaccine in infants according to HIV status.

“One death (sudden infant death syndrome; HEU group; 3 days post-dose 1) was considered potentially vaccine-related.”

#Sudden #Infant #Death #Syndrome #SIDS #Pneumococcal
#Vaccine #MedScienceResearch