Hypotonic-Hyporesponsive Episodes

“A hypotonic-hyporesponsive episode (HHE) is a sudden and unexpected episode of loss of tone, unresponsiveness and colour change which uncommonly affects infants and children after vaccination.” – MS Gold, PubMed

Near miss. Also see category, sudden infant death syndrome

Hypotonic hyporesponsive episode and the 13-valent pneumococcal vaccine.

“Hypotensive-hyporesponsive episodes are rare events after immunizations performed for diphtheria, tetanus, Haemophilus influenzae type b and hepatitis B virus vaccines, but most of the reported episodes have been associated with pertussis-containing vaccines. We report the case of a 3-month-old girl, previously healthy otherwise, presenting with the unusual event of a hypotonic-hyporesponsive episode after vaccination with the 13-valent pneumococcal vaccine. Diagnosis was established after a thorough evaluation of the patient and by exclusion of other clinical conditions.”

#HHE #Pneumococcal #Hypotonic #Hyporesponsive #Episode #Pertussis #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25818964/

🛑 Hypotonic-hyporesponsive episode in a 7-month-old infant after receipt of multiple vaccinations.

“A 7-month-old boy became difficult to arouse, was limp and had blue extremities 8 hours after immunization with intravenous poliovirus, diphtheria-tetanus toxoids-acellular pertussis, Haemophilus influenzae type b-hepatitis B virus and pneumococcal vaccines. The hypotonic-hyporesponsive episode had resolved by the time the infant was seen in an emergency department 1 hour later. The report describes hypotonic-hyporesponsive episode, encourages reporting of vaccine-associated adverse events and discusses prognosis and implications for subsequent immunization.”

#Hypotonic #Hyporesponsive #HHE #Polio #DTaP #Hib #Hepatitis B #Pneumococcal
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/16282941/

Hypotonic-hyporesponsive episodes reported to the Vaccine Adverse Event Reporting System (VAERS), 1996-1998.

#Hypotonic #Hyporesponsive #HHE #DTP #DTaP #Hib
#VAERS #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/11015547

Vaccine-related adverse events in Cuban children, 1999-2008.

“The DTwP vaccine exhibited the highest rate of adverse events. Common minor events were: fever (17,538), reactions at injection site (4470) and systemic side effects (2422). Rare events (by WHO definition) reported were: persistent crying (2666), hypotonic-hyporesponsive episodes (3), encephalopathy (2) and febrile seizures (112). Severe events included: anaphylaxis (2), respiratory distress (1), multiple organ failure (1), sudden death (1), vaccine-associated paralytic poliomyelitis (2), toxic shock syndrome (3), and sepsis (1). The 10 deaths and 3 cases of disability were investigated by an expert commission, which concluded that 8 of the 13 severe events were vaccination-related.”

#Death #DTP #Seizures #HHE #Encephalopathy #Polio #Respiratory #Anaphylaxis #Neurological #Vaccine #Failure #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/22334111/