Paralysis

Acute flaccid paralysis surveillance indicators in the Democratic Republic of Congo during 2008-2014.

“Of the 13,749 AFP cases investigated, 58.9% received at least three doses of oral polio vaccine (OPV), 7.3% never received OPV, while the status of 18.3% was unknown.”

#Polio #Paralysis #Neurological
#Vaccine #Failure #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/27642491

[Acute maternal anterior poliomyelitis in a non-endemic zone].

“The authors report the case of a 26 year old woman with acute anterior poliomyelitis contracted during the vaccination of her baby. Despite having been herself vaccinated in infancy she was not protected against the poliovirus. The clinical interest of this uncommon case is a severe paralytic state with definitive paraplegia.”

#Recently #Vaccinated #Shedding
#Polio #Paralysis #Neurological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/2561040/

Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine.

#Rabies #Paralysis #Neurological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/9846820/

ANTIRABIES ANTIBODY RESPONSE IN MAN TO VACCINE MADE FROM INFECTED SUCKLING-MOUSE BRAINS.

“Antirabies vaccines produced from infected brains of adult mammals have always had the potentiality of causing post-vaccinal paralysis or allergic encephalitis in man. Attempts in recent years either to remove the paralytic factor from brain-tissue vaccines or to use as the virus source infected tissue other than nervous tissue (e.g., chick embryos) have usually resulted in a substantial reduction of the specific antirabies potency.”

#Rabies #Paralysis #Neurological #Encephalitis #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/14163964/

[A case of Guillain-BarrΓ© syndrome following cholera vaccination (author’s transl)].

“A 45-year-old woman developed bilateral ascending flaccid paralysis after cholera vaccination, 15 days after the first and 1 day after the second injection. The clinical course resulted in nearly complete paralysis of the lower limbs, paresis of the upper limbs and partial involvement of the cranial nerves. There was only slight sensory loss. The CSF revealed no pleocytosis and a protein level of 206 mg/100 ml. Recovery began 2 weeks later and was almost complete after 2 months. Immunological investigations revealed no remarkable changes.”

#Guillain #Barre #Paralysis #Neurological #Cholera #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/50424/

πŸ›‘ Case report of post sheep brain rabies vaccine neuroparalytic complications at Tikur Anbessa Teaching Hospital, in Ethiopia.

“We report four cases of ascending paralysis admitted to Tikur Anbessa Specialized Hospital (TASH) within six months period between December 2010 and June 2011 following administration of sheep brain tissue anti rabies vaccine for presumed rabies exposure. The paralysis started after a minimum of twelve doses of the vaccine. Two of the patients were discharged with severe paralysis and two died in the hospital.”

#Death #Rabies #Paralysis #Vaccine #Neurological #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/23409403/

Characteristics of poliovirus strains from long-term excretors with primary immunodeficiencies.

“Individuals who are deficient in humoral immunity are particularly at risk from infection with enteroviruses, and poliovirus in particular, where antibodies are the main source of protection from disease. Long-term excretion of vaccine strains of poliovirus has been documented for many years and instances of paralytic poliomyelitis in hypogammaglobulinaemic patients who were subsequently found to have been excreting virus for prolonged periods have been reported in the U.S.A., Germany and Japan. The identification of a healthy immunodeficient patient in the U.K. who has probably been excreting type 2 poliovirus for 15 years will be described, with the characteristics of the virus and the results of attempts at treatment so far. Such individuals pose a significant risk to the eradication programme unless they can be identified and treated.”

#Shedding #Polio #Vaccine #Failure #Paralysis #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/11763340

πŸ›‘ Guillain-BarrΓ© Syndrome after H1N1 Shot in Pregnancy: Maternal and Fetal Care in the Third Trimester-Case Report.

“We presented a case of a 36-year-old pregnant woman that was immunized to H1N1 in the last trimester; 10 days later she developed shoulder and lumbar spine’s pain, limbs weakness and facial paralysis with unfavorable clinical evolution and was submitted to intensive therapy care. We described clinical and obstetrical approach, pointing out peculiarities involved in this pathology in pregnancy.”

#Pregnancy #Paralysis #Guillain #Barre #Neurological #Influenza #Flu #H1N1 #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521405/

Guillain – Barre’ syndrome following recombinant hepatitis B vaccine and literature review.

“A 17 year-old woman developed progressive quadriparesis with bilateral facial diplegia after immunization with recombinant hepatitis B vaccine 3 days prior. Cerebrospinal fluid analysis revealed acellular fluid with high protein level. The electrodiagnosis was compatible with demyelinating polyneuropathy. Other potential causes of Guillain-Barre’ syndrome (GBS) were ruled out. Her motor power gradually improved and returned to normal later. The temporal relationship between GBS and vaccination was suggestive of a vaccine-induced cause. Mechanisms of this very rare complication are proposed with a literature review.”

#Paralysis #Vaccine #Neurological #Hepatitis B #Guillain #Barre #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/11075984/

πŸ›‘ Imported Vaccine-Associated Paralytic Poliomyelitis — United States, 2005

“This report describes the first known occurrence of imported VAPP in an unvaccinated U.S. adult who traveled abroad, where she likely was exposed through contact with an infant recently vaccinated with OPV.”

“Upon admission to a hospital in Phoenix, the patient had bilateral areflexic lower extremity weakness and respiratory failure requiring intubation.”

“The host family’s son and daughter-in-law lived next door with two children, aged 2 months and 3 years, who visited the host family frequently. The infant received his first dose of OPV on January 19, 2005, 4 days after the woman arrived to live with the host family.”

#Recently #Vaccinated #Shedding
#Polio #Paralysis
#Neurological #Respiratory
#Vaccine #MedScienceResearch

https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5504a2.htm
https://www.ncbi.nlm.nih.gov/m/pubmed/16456525/

πŸ›‘ LESSONS FROM THE SALK POLIO VACCINE: METHODS FOR AND RISKS OF RAPID TRANSLATION

“Regretfully, the story of polio vaccine was not without tragedy. In April 1955, soon after mass polio vaccination began in the United States, reports trickled in to the Surgeon General concerning atypical cases of paralytic polio. Several paralytic polio cases were reported in California in patients who had received the polio vaccine about a week earlier but the paralysis only affected the arm or leg in which they received the injection. Each of these cases occurred in polio vaccine produced by Cutter pharmaceutical company. The Surgeon General immediately pulled all Cutter polio vaccine, but it was too late; nearly 400,000 children had been inoculated with Cutter polio vaccine and 250 cases of atypical paralytic polio occurred. There were also reports of the Wyeth pharmaceutical company polio vaccine causing paralysis and death in several children in the northeastern United States.

It was soon discovered that some lots of Cutter and Wyeth polio vaccine were insufficiently inactivated with formalin leading to live polio virus in more than 100,000 doses. In fact, 16 lots of Cutter polio vaccine were retested and the first 6 lots produced were positive for live polio virus. These incidents demonstrated the lack of oversight and safeguards put into place before the vaccine was made so widely available.”

#Polio #Vaccine #Failure
#Cutter #Paralysis
#Incomplete #Inactivation
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928990/

Mechanism of Injury-Provoked Poliomyelitis

#Polio #Vaccine #Failure
#Paralysis #Neurological
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110068/

MRI findings in an infant with vaccine-associated paralytic poliomyelitis.

“We report a Brazilian infant who developed VAPP 40 days after receiving the first dose of oral polio vaccine (OPV). MR images of the cervical and thoracic spinal cord showed lesions involving the anterior horn cell, with increased signal intensity on T2-weighted sequences. We would like to emphasize the importance of considering VAPP as a differential diagnosis in patients with acute flaccid paralysis and an MRI showing involvement of medulla oblongata or spinal cord, particularly in countries where OPV is extensively administered.”

#Polio #Vaccine #Failure #Paralysis #Neurological #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/20440488/

The muscle findings in a pediatric patient with live attenuated oral polio vaccine-related flaccid monoplegia.

#Polio #Vaccine #Paralysis #Neurological #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25131733/

Neonatal paralytic poliomyelitis. A case report.

“We report a child who became symptomatic with apnea at 18 days of age and who subsequently developed a permanent monoparesis. Serologic and cultural evidence indicated the virus as poliovirus vaccine type. Another infant who received live oral poliovirus vaccine was probably the source of the infecting virus.”

#Shedding #Polio
#Recently #Vaccinated #Paralysis #Apnea #Respiratory
#Vaccine #Failure
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/3947264/

[Neurologic complications due to a sample type of rabies vaccination].

#Rabies #Neurological #Paralysis #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/3447020/

Neurologic complications in oral polio vaccine recipients.

“A vaccine-like strain of poliovirus was isolated from each patient, and each had symptoms (left leg paralysis in three; developmental regression, spasticity, and progressive fatal cerebral atrophy in one) persisting for at least 6 months.”

#Polio #Neurological #Neurodevelopmental #Paralysis #Vaccine #Failure #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/3012055/

πŸ›‘ Neuroparalytic accidents of antirabies vaccination with suckling mouse brain vaccine. Clinical and pathologic study of 21 cases.

“Twenty-one cases of neuroparalytic accidents of rabies vaccination (with suckling mouse brain vaccine), 11 of them fatal, were observed, occurring predominantly in men; the mean age of the patients was 29 years.”

#Death #Paralysis #Neurological #Vaccine #Rabies #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/911231/

A novel vaccinological evaluation of intranasal vaccine and adjuvant safety for preclinical tests.

“However, the addition of adjuvants to vaccines may cause unwanted immune responses, including facial nerve paralysis and narcolepsy. ”

#Narcolepsy #Paralysis
#Neurological
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/28063707/

Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus.

“An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.”

#Shedding #Death #Polio
#Recently #Vaccinated
#Vaccine #Failure #Paralysis
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/11896235/

Paralytic poliomyelitis associated with the Sabin 3 revertant strain of poliovirus in Bahrain.

#Polio #Vaccine #Failure #Paralysis #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/11579860

πŸ›‘ Polio eradication in India: some observations.

“Oral polio vaccine (OPV) has failed to provide full protection to many children who have developed paralytic polio even after taking 10 or more doses of OPV. In some children, OPV has caused paralysis-vaccine associated paralytic polio (VAPP). Number of children developing polio due to vaccine is high and on increase.”

#Polio #Vaccine #Failure #Paralysis #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/15532129

Poliomyelitis Associated With Type 2 Virus
Paralytic Disease in the Father of a Recently Immunized Child

“Paralytic poliomyelitis was diagnosed clinically in a 29-year-old man three weeks after his 2-year-old son received trivalent live oral poliovirus vaccine. Type 2 poliovirus with “vaccine-like” characteristics was isolated from the patient’s stool, and the serum showed a significant rise in neutralizing antibody against type 2 virus. There was no rise in complement fixation antibody titers. The patients illness was likely due to type 2 poliovirus contracted from his son. Physicians should inquire about the immunization status of parents before administering vaccine to children.”

#Recently #Vaccinated #Shedding #Polio #Paralysis #Vaccine
#MedScienceResearch

http://jamanetwork.com/journals/jama/article-abstract/335320

Sudden hearing loss after rabies vaccination.

“BACKGROUND: Sudden hearing loss developing after immunisation is a very rare situation. Rabies is a viral disease characterised by encephalitis and death. Treatment involves active and passive immunisation. Neurologic complications including Guillain-Barre syndrome or facial paralysis are reported in the literature as a side effect after rabies immunisation.

CASE REPORT: Sudden hearing loss was detected in an 11 year-old male patient who had taken the medication for rabies immunisation.

CONCLUSION: This study presents a case report of sudden hearing loss developing after rabies immunisation – no other aetiological factors were detected and clinical management is discussed in light of the literature.”

#Hearing #Loss #Rabies #Guillain #Barre #Facial #Paralysis #Vaccine
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25207131/

Update on vaccine-derived polioviruses–worldwide, July 2009-March 2011.

#Shedding #Vaccine #Failure #Polio #Paralysis #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/21716199/

Use of a novel real-time PCR assay to detect oral polio vaccine shedding and reversion in stool and sewage samples after a mexican national immunization day.

“During replication, oral polio vaccine (OPV) can revert to neurovirulence and cause paralytic poliomyelitis. In individual vaccinees, it can acquire specific revertant point mutations, leading to vaccine-associated paralytic poliomyelitis (VAPP). With longer replication, OPV can mutate into vaccine-derived poliovirus (VDPV), which causes poliomyelitis outbreaks similar to those caused by wild poliovirus. After wild poliovirus eradication, safely phasing out vaccination will likely require global use of inactivated polio vaccine (IPV) until cessation of OPV circulation.”

#Shedding #Polio #Paralysis
#Vaccine #Failure
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/21411577

Vaccine-associated contact paralytic poliomyelitis with atypical neurological presentation.

“Paralytic poliomyelitis presenting with quadriparesis, transient encephalitis and bulbar symptoms in 2 patients in close contact with recently vaccinated children with trivalent live oral polio vaccine is described. Symmetrical lower motor neuron involvement of deltoid muscles with electromyographic confirmation was found. Upper motor neuron signs, with symmetrical hyperactive deep tendon reflexes developed in the lower extremities. Poliovirus Type-2 vaccine-like strain was cultured from one patient and both patients showed significant antibody titers rises to poliovirus. Attention is drawn to the possible clinical differences between vaccine associated poliomelitis and the usual features found in wild strain poliomyelitis. It is suggested that in selected cases, non-immunized contacts be given inactivated polio-vaccine when the vaccinees are immunized with the live oral-vaccine.”

#Shedding #Recently #Vaccinated #Paralysis #Polio #Encephalitis
#Neurological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/3687370/

πŸ›‘ Vaccine-associated paralytic poliomyelitis: a case report of domiciliary transmission.

“We herein present the case of an unvaccinated child, with a clinical picture of an acute anterior poliomyelitis associated with the live strain vaccine, whose brother received the Sabin vaccine 20 days before the onset of the symptoms. Vaccine strain of the type 3 poliovirus was isolated in fecal culture and a presented mutation in nucleotide 472 (C–>U) in the 5′ non-coding region, which is strongly related to the higher strain virulence.”

#Shedding #Polio #Paralysis
#Recently #Vaccinated
#Neurological #Unvaccinated
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/10983013/

Vaccine-associated paralytic poliomyelitis caused by contact infection.

“We encountered an adult patient with acute anterior poliomyelitis (AAP), whose monoparesis developed 28 days after his son’s immunization with oral poliovirus vaccine (OPV). Neurological and electrophysiological examinations suggested that his muscular wasting of the left lower limb was due to a lower motor neuron disorder, and magnetic resonance imaging revealed the responsible lesion in the left anterior horn at the thoracolumbar junction. His stool was found to include poliovirus type 3, mainly originating from Sabin 3 by neutrization antibody and PCR-restriction fragment length polymorphism method. This indicated that the AAP resulted from contact with his son.”

#Shedding #Polio #Paralysis
#Recently #Vaccinated
#Neurological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/16617188/

VACCINE-ASSOCIATED POLIOMYELITIS IN A CHILD WITH THYMIC ABNORMALITY

#Polio #Shedding #Death #Paralysis #Vaccine #Failure #MedScienceResearch

http://pediatrics.aappublications.org/content/48/6/923

Vaccine-induced polioencephalomyelitis in Scotland.

“A six-month-old British female, living in Glasgow was admitted in June 1986 with a four-day history of fever and lower limb weakness following immunisation with oral polio and triple (DTP) vaccines. Examination revealed paralysis of all limbs, facial muscles and right diaphragm, scoliosis, opsoclonus and ocular flutter. Poliovirus types 1, 2 and 3, isolated from her stool specimens were all vaccine-like strains.”

#Polio #Vaccine #Failure #Paralysis #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/2847313/