Musculoskeletal

Adjuvants- and vaccines-induced autoimmunity: animal models.

“In some cases, adjuvants may trigger generalized autoimmune response, resulting in multiple auto-antibodies, but sometimes they can reproduce human autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, autoimmune thyroiditis and antiphospholipid syndrome and may provide insights about the potential adverse effects of adjuvants.”

#Thyroid #Arthritis #Lupus #Sjogren #Autoimmunity #Antiphospholipid #Animals #Veterinary #Musculoskeletal #Neurological #Vaccine
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/27417999

A case of systemic lupus erythematosus (SLE) following Human papillomavirus (HPV) vaccination.

“A 15-year-old young woman received the Human papillomavirus (HPV) vaccines. Following the second HPV vaccination, intermittent fever, myalgia, arthritis and malar rash developed, and she was admitted to our hospital. Laboratory studies showed positive results for antinuclear antibody, anti-dsDNA antibody and anti-Sm antibody. Systemic lupus erythematosus (SLE) was diagnosed according to the Systemic Lupus International Collaborative Clinics 2012. Magnetic resonance imaging showed abnormal hyperintense areas in the fascia, and en bloc biopsy showed fasciitis. Treatment with prednisolone resulted in an amelioration of the symptoms. Reportedly, SLE developed after HPV vaccinations in some patients. Most such patients have a past or family history of autoimmune disease and presented SLE symptoms after the second vaccination. We describe herein a patient in whom SLE developed in association with HPV vaccination.”

#Gardasil #Lupus #SLE #HPV #Autoimmunity #Arthritis #Musculoskeletal #Vaccine
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/27212601/

? [Complications of pertussis immunization (author transl)].

“16 cases of neurological disease and/or death shortly after pertussis immunization are reported. Eight patients had convulsions, six with ensuing permanent defects. Severe polymyositis was observed in one case. Five infants died 12 h to 4 days after vaccination: two after acute encephalopathy and three in the form of a sudden unexpected death (SID). In two fatal cases the morphological changes in the brain corresponded to those of pertussis encephalopathy: neuronal degeneration in various parts of the cortex, especially in the region of the ammons horn, and in the cerebellum. There were no signs of inflammation. Three cases underwent forensic autopsy and death was attributed to bronchopulmonary infection. Complete neuropathological work-up was only done in one case, in which the brain was normal. The critique of episodical reports and the demand for prospective studies is appreciated. Knowledge of all possible forms of complications, however, is indispensable for future investigations. Polymyositis and SID have so far not been listed as abnormal reactions to immunization. The majority of our cases became known accidentally from hospital sheets or from discussions with collegues. For a detection of all possible cases a greater awareness of doctors for the problem of pertussis immunization appears necessary. Only another 23 cases have been reported to the health authorities of the state of Lower Saxony during the last 6 to 7 years. Of those, nine were either harmless reactions or diseases probably unrelated to vaccination. Two were cases of SID, 12 and 72 h after vaccination. It is concluded that only a minor proportion of possible complications is presently reported to the health authorities.”

#Sudden #Infant #Death #Syndrome #SIDS #Pertussis #Neurological #Seizures #Encephalopathy
#Musculoskeletal
#Respiratory #Vaccine
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/18670/?

Experimental scoliosis in primates: a neurological cause.

“A series of monkeys is presented where scoliosis developed incidentally during the routine virulence testing of live, attenuated, oral poliomyelitis vaccines by intraspinal injection.”

#Scoliosis #Vaccine #Neurological #Polio #Musculoskeletal
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/6284765/

Extranodal MALT Lymphoma of the Right Triceps Muscle following Influenza Vaccine Injection: A Rare Case with an Interesting Presentation.

#Cancer #Influenza #Flu #Vaccine #Musculoskeletal #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/22084699/

See section on “fibromyalgia.”

See section on “macrophagic myofasciitis.”

Macrophagic myofasciitis associated with vaccine-derived aluminium.

“Macrophagic myofasciitis is characterised by sheets of macrophages in striated muscle, a few lymphocytes and inconspicuous muscle fibre damage. It is due to aluminium contained in vaccines, and is localised to the inoculation site. We report the first Australian case, detected incidentally when investigating a raised serum creatine kinase level.”

#Macrophagic #Myofasciitis #Aluminum #Musculoskeletal #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/16053418/

Major Birth Defects after Vaccination Reported to the Vaccine Adverse Event Reporting System (VAERS), 1990 to 2014.
(2017)

“We identified 50 reports of major birth defects; in 28 reports, the vaccine was given during the first trimester; 25 were reports with single vaccines administered.”

#Pregnancy #Birth #Defects #VAERS #Musculoskeletal #Neurological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/28398711/

Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations.

#ASIA #Autoimmunity #Hepatitis B
#Psychiatric #Musculoskeletal #Gastrointestinal #Aluminum
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/22235057/

Rhabdomyolysis with acute renal failure triggered by the seasonal flu vaccination in a patient taking simvastatin.

#Kidney #Musculoskeletal #Influenza #Flu #Vaccine #MedScienceResearch
https://www.ncbi.nlm.nih.gov/m/pubmed/22778082/

[Septic dislocation of the hip secondary to BCG vaccination].

“We report a case of septic dislocation of the hip in an eight-month-old infant secondary to BCG vaccination. The usual treatment of septic arthritis with surgical drainage and broad spectrum antibiotics was unsuccessful. Cure was achieved after institution of an anti-tuberculosis treatment and a second surgical drainage. This rare complication of BCG vaccination can develop several months after administration of the vaccine.”

#BCG #Musculoskeletal #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/16609619/

Undifferentiated connective tissue disease, fibromyalgia and the environmental factors. 2017

“UCTD exposed to major ASIA triggers (vaccines, silicone) displayed typical features of ASIA (general weakness, chronic fatigue, irritable bowel syndrome) in the context of a predisposing genetic background (familiarity for autoimmunity).”

#Fibromyalgia #ASIA #Autoimmunity #Musculoskeletal #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/28368979/