Molecular Mimicry

Acquired autoimmunity after viral vaccination is caused by molecular mimicry and antigen complimentarity in the presence of an immunologic adjuvant and specific HLA patterns.

#Autoimmunity #HLA #Molecular #Mimicry #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/17630224/

Acute Disseminated Encephalomyelitis Following Immunization with Human Papillomavirus Vaccines.

#Gardasil #Neurological #ADEM #Encephalomyelitis #HPV #Molecular #Mimicry #Vaccine #MedScienceResearch

https://www.jstage.jst.go.jp/article/internalmedicine/55/21/55_55.7217/_article

? Adverse effect versus quality control of the Fuenzalida-Palacios antirabies vaccine.

“We evaluated the components of the Fuenzalida-Palacios antirabies vaccine, which is till used in most developing countries in human immunization for treatment and prophylaxis. This vaccine is prepared from newborn mouse brains at 1% concentration. Even though the vaccine is considered to have a low myelin content, it is not fully free of myelin or of other undesirable components that might trigger adverse effects after vaccination. The most severe effect is a post-vaccination neuroparalytic accident associated with Guillain-Barré syndrome. In the present study we demonstrate how the vaccines produced and distributed by different laboratories show different component patterns with different degrees of impurity and with varying protein concentrations, indicating that production processes can vary from one laboratory to another. These differences, which could be resolved using a better quality control process, may affect and impair immunization, with consequent risks and adverse effects after vaccination. We used crossed immunoelectrophoresis to evaluate and demonstrate the possibility of quality control in vaccine production, reducing the risk factors possibly involved in these immunizing products.”

#Contamination #MouseBrain #Guillain #Barre #Neurological #Rabies #Vaccine #Error #Molecular #Mimicry #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/10030074

Application of the immunological disease continuum to study autoimmune and other inflammatory events after vaccination.

#Autoimmunity #Molecular #Mimicry #Immune #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/21036134

Autoimmune hazards of hepatitis B vaccine.

#Autoimmunity #Hepatitis B #Molecular #Mimicry
#Vaccine #MedScienceResearch

http://www.ncbi.nlm.nih.gov/pubmed/15722255

Chronic anterior uveitis following bacille Calmette-Guérin vaccination: molecular mimicry in action?

#Ophthalmological #BCG #Uveitis #HLA #Eyes #Molecular #Mimicry #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/18705627

HLA haplotype in a patient with systemic lupus erythematosus triggered by hepatitis B vaccine.

#Lupus #Autoimmunity #HLA
#Hepatitis B #Molecular #Mimicry #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/20630136

Multiple sclerosis and hepatitis B vaccination: could minute contamination of the vaccine by partial hepatitis B virus polymerase play a role through molecular mimicry?

“Reports of multiple sclerosis developing after hepatitis B vaccination have led to the concern that this vaccine might be a cause of multiple sclerosis in previously healthy subjects. Some articles evidenced that minor Hepatitis B virus (HBV) polymerase proteins could be produced by alternative transcriptional or translational strategies. Their detection is very difficult because they are in minute concentration and probably enzymatically inactive, however, it was shown that they could be exposed on the outside of the virus particles and also be immunogenic. In addition, HBV polymerase shares significant amino acid similarities with the human myelin basic protein. We hypothesise that some of the apparent adverse reactions to the vaccine could be due to a process called of molecular mimicry, the HBV polymerase, which could be a contaminant in the recombinant or plasma-derived vaccines, could act as autoantigens and induce autoimmune demyelinating diseases such as multiple sclerosis.”

#Multiple #Sclerosis #Hepatitis B
#Autoimmunity #Molecular #Mimicry #Contamination
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/15908138/

Pancreatitis after human papillomavirus vaccination: a matter of molecular mimicry

#Gardasil #HPV #Pancreatitis #Autoimmunity #Vaccine
#MedScienceResearch #Molecular #Mimicry

http://www.ncbi.nlm.nih.gov/m/pubmed/27421720/

Postural tachycardia syndrome following human papillomavirus vaccination.

#Gardasil #POTS #Molecular #Mimicry #HPV #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/24102827/