Lupus

Adjuvants- and vaccines-induced autoimmunity: animal models.

“In some cases, adjuvants may trigger generalized autoimmune response, resulting in multiple auto-antibodies, but sometimes they can reproduce human autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, autoimmune thyroiditis and antiphospholipid syndrome and may provide insights about the potential adverse effects of adjuvants.”

#Thyroid #Arthritis #Lupus #Sjogren #Autoimmunity #Antiphospholipid #Animals #Veterinary #Musculoskeletal #Neurological #Vaccine
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/27417999

Autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine.

“This was a case study in which 3 patients with autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination (HPV) were evaluated and described. All the patients were women. Diagnosis consisted of HLA-B27 enthesitis related arthritis, rheumatoid arthritis and systemic lupus erythematous, respectively. Our results highlight the risk of developing ASIA after HPV vaccination and may serve to increase the awareness of such a complication. Factors that are predictive of developing autoimmune diseases should be examined at the population level in order to establish preventive measures in at-risk individuals for whom healthcare should be personalized and participatory.”

#Gardasil #ASIA #Autoimmunity #HLA #Arthritis #Lupus #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25962455/

? Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity.

#Thyroid #Autoimmunity #ASIA #HLA #Lupus #Arthritis #Hashimotos #Vaccine #MedScienceResearch

Full article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256113/

https://www.ncbi.nlm.nih.gov/m/pubmed/28167927/

A case-control study of quadrivalent human papillomavirus vaccine-associated autoimmune adverse events.

“It was observed that cases with the SAAE outcomes of gastroenteritis (odds ratio (OR) = 4.6, 95% confidence interval (CI) = 1.3-18.5), arthritis (OR = 2.5, 95% CI = 1.4-4.3), systemic lupus erythematosus (OR = 5.3, 95% CI = 1.5-20.5), vasculitis (OR = 4, 95% CI = 1.01-16.4), alopecia (OR = 8.3, 95% CI = 4.5-15.9), or CNS conditions (OR = 1.8, 95% CI = 1.04-2.9) were significantly more likely than controls to have received HPV4 vaccine (median onset of SAAE symptoms from 6 to 55 days post-HPV4 vaccination).”

#Gardasil #Lupus #Arthritis #Autoimmunity #HPV #Hair #Loss
#Gastrointestinal #Alopecia #Neurological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25535199/

A case of systemic lupus erythematosus (SLE) following Human papillomavirus (HPV) vaccination.

“A 15-year-old young woman received the Human papillomavirus (HPV) vaccines. Following the second HPV vaccination, intermittent fever, myalgia, arthritis and malar rash developed, and she was admitted to our hospital. Laboratory studies showed positive results for antinuclear antibody, anti-dsDNA antibody and anti-Sm antibody. Systemic lupus erythematosus (SLE) was diagnosed according to the Systemic Lupus International Collaborative Clinics 2012. Magnetic resonance imaging showed abnormal hyperintense areas in the fascia, and en bloc biopsy showed fasciitis. Treatment with prednisolone resulted in an amelioration of the symptoms. Reportedly, SLE developed after HPV vaccinations in some patients. Most such patients have a past or family history of autoimmune disease and presented SLE symptoms after the second vaccination. We describe herein a patient in whom SLE developed in association with HPV vaccination.”

#Gardasil #Lupus #SLE #HPV #Autoimmunity #Arthritis #Musculoskeletal #Vaccine
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/27212601/

? Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

“After reviewing the literature, we observed that complications seen after Hepatitis B vaccination are sudden infant death syndrome, multiple sclerosis, chronic fatigue syndrome, idiopathic thrombocytopenic purpura, vasculititis optic neuritis, anaphylaxis, systemic lupus erytymatosus, lichen planus and neuro-muscular disorder.”

#Sudden #Infant #Death #Syndrome #SIDS #Hepatitis B #Multiple #Sclerosis #Neurological #Chronic #Fatigue #Syndrome #Lupus #Dermatological #Anaphylaxis #Ophthalmological #Thrombocytopenia
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25506472/

HLA haplotype in a patient with systemic lupus erythematosus triggered by hepatitis B vaccine.

#Lupus #Autoimmunity #HepatitisB #Molecular #Mimicry #HLA #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/20630136

Human papillomavirus vaccine and systemic lupus erythematosus.

#Lupus #Autoimmunity
#Gardasil #HPV #Vaccine
#MedScienceResearch

http://www.ncbi.nlm.nih.gov/m/pubmed/23624585/

Induction of lupus autoantibodies by adjuvants.

#Lupus #Autoimmunity #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/12892730

Ten cases of systemic lupus erythematosus related to hepatitis B vaccine.

#Lupus #Hepatitis B #Vaccines #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/19880567/

Vaccinations and risk of systemic lupus erythematosus and rheumatoid arthritis: A systematic review and meta-analysis.
(2017)

“The pooled findings suggested that vaccinations significantly increased risk of SLE (RR=1.50; 95%CI 1.05-2.12, P=0.02). In addition, there was an obvious association between vaccinations and increased risk of RA (RR=1.32; 95%CI 1.09-1.60, P=0.004). Meta-analysis of studies reporting outcomes of short vaccinated time also suggested that vaccinations could significantly increase risk of SLE (RR=1.93; 95%CI 1.07-3.48, P=0.028) and RA (RR=1.48; 95%CI 1.08-2.03, P=0.015).”

#Lupus #Arthritis #Autoimmunity
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/28483543/