Gastrointestinal

Adverse events following Haemophilus influenzae type b vaccines in the Vaccine Adverse Event Reporting System, 1990-2013.

“Includes 29 747 reports after Hib vaccines; 5179 (17%) were serious, including 896 reports of deaths. Median age was 6 months (range 0-1022 months). Sudden infant death syndrome was the stated cause of death in 384 (51%) of 749 death reports with autopsy/death certificate records.”

#SIDS #Sudden #Infant #Death #Syndrome #Hib #VAERS #Gastrointestinal #Neurological #Vaccine #MedScienceResearch

http://www.ncbi.nlm.nih.gov/m/pubmed/25598306/

An analysis of rotavirus vaccine reports to the vaccine adverse event reporting system: more than intussusception alone?

#Gastrointestinal #Rotavirus #Intussusception #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/15060267

Bivalent HPV vaccine safety depending on subtypes of juvenile idiopathic arthritis.

#Arthritis #Gardasil #Gastrointestinal #HPV #Autoimmunity #HLA
#Vaccine #MedScienceResearch

http://ard.bmj.com/content/73/12/e75.long

A case-control study of quadrivalent human papillomavirus vaccine-associated autoimmune adverse events.

“It was observed that cases with the SAAE outcomes of gastroenteritis (odds ratio (OR) = 4.6, 95% confidence interval (CI) = 1.3-18.5), arthritis (OR = 2.5, 95% CI = 1.4-4.3), systemic lupus erythematosus (OR = 5.3, 95% CI = 1.5-20.5), vasculitis (OR = 4, 95% CI = 1.01-16.4), alopecia (OR = 8.3, 95% CI = 4.5-15.9), or CNS conditions (OR = 1.8, 95% CI = 1.04-2.9) were significantly more likely than controls to have received HPV4 vaccine (median onset of SAAE symptoms from 6 to 55 days post-HPV4 vaccination).”

#Gardasil #Lupus #Arthritis #Autoimmunity #HPV #Hair #Loss
#Gastrointestinal #Alopecia #Neurological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25535199/

Detection of fecal shedding of rotavirus vaccine in infants following their first dose of pentavalent rotavirus vaccine.

#Shedding #Rotavirus #Failure #Gastrointestinal #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/21477676/

Gastrointestinal adverse reactions following anthrax vaccination: an analysis of the Vaccine Adverse Events Reporting System (VAERS) database.

“RESULTS: Anthrax vaccine was one of the most reactogenic vaccines included in VAERS. The incidence of adverse reactions reported following anthrax vaccine was higher for every reaction analyzed in comparison to the adult vaccine control groups.”

#Anthrax #Gastrointestinal #VAERS #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/15143911/

Gastrointestinal immunopathology and food allergy.

“In contrast to the beneficial expressions of gastrointestinal-associated lymphoid tissue, which are seen with relevance to newer methods of delivery of vaccines directly applied to the gastrointestinal mucosal surfaces (eg, oral poliovirus, rotavirus, Salmonella typhi vaccines), the adverse consequences of a mucosal immune response gone astray are evidenced in many diseases such as FA. A classification of clinical disorders associated with FA based on classic mechanisms of immunologic injury is presented, which includes the following: (1) IgE-mediated, (2) non-IgE-mediated, and (3) mixed IgE- and non-IgE-mediated disorders. Our study of immunologic disturbance in patients with non-IgE FA revealed a pattern of increased CD4+ and decreased TH1 cell counts in peripheral blood mononuclear cells in contrast to patients with celiac disease, where a pattern of increased CD8+ and TH1 cell counts in peripheral blood mononuclear cells and increased CD8+ cell counts was seen.”

#Food #Allergies #Gastrointestinal #Polio #Rotavirus #Immune #Vaccine
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/15562871/

Hepatitis B vaccination and adult associated gastrointestinal reactions: a follow-up analysis.

#Hepatitis B #Gastrointestinal #Vaccine #Liver #Hepatitis #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/12397738/

Horizontal transmission of rhesus monkey rotavirus-based quadrivalent vaccine during a phase 3 clinical trial in Caracas, Venezuela.

#Shedding #Rotavirus #Gastrointestinal #Vaccine #Failure #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/12599053/

Is measles vaccination a risk factor for inflammatory bowel disease?

Thompson NP, et al. Lancet. 1995.

“Measles virus may persist in intestinal tissue, particularly that affected by Crohn’s disease, and early exposure to measles may be a risk factor for the development of Crohn’s disease. Crohn’s disease and ulcerative colitis occur in the same families and may share a common aetiology. In view of the rising incidence of inflammatory bowel disease (Crohn’s disease and ulcerative colitis), we examined the impact of measles vaccination upon these conditions. Prevalences of Crohn’s disease, ulcerative colitis, coeliac disease, and peptic ulceration were determined in 3545 people who had received live measles vaccine in 1964 as part of a measles vaccine trial. A longitudinal birth cohort of 11,407 subjects was one unvaccinated comparison cohort, and 2541 partners of those vaccinated was another. Compared with the birth cohort, the relative risk of developing Crohn’s disease in the vaccinated group was 3.01 (95% CI 1.45-6.23) and of developing ulcerative colitis was 2.53 (1.15-5.58). There was no significant difference between these two groups in coeliac disease prevalence. Increased prevalence of inflammatory bowel disease, but not coeliac disease or peptic ulceration, was found in the vaccinated cohort compared with their partners. These findings suggest that measles virus may play a part in the development not only of Crohn’s disease but also of ulcerative colitis.”

#Measles #Vaccine #Crohns #Ulcerative #Colitis #Gastrointestinal #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/7715338/

Measles-mumps-rubella vaccination induced thrombocytopenia: a case report and review of the literature.

“We report a case of ITP after measles-mumps-rubella (MMR) vaccination in a 10-month-old male infant who presented with purpura and acute gastrointestinal bleeding.”

#MMR #Thrombocytopenia #Gastrointestinal #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25417506/

Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden.

“Relative risks were significantly increased for Bell’s palsy, paraesthesia, and inflammatory bowel disease after vaccination, predominantly in the early phase of the vaccination campaign.”

#Neurological #Autoimmunity #Gastrointestinal #Bells #Palsy #H1N1 #Influenza #Flu #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/21994316

Persistent rotavirus vaccine shedding in a new case of severe combined immunodeficiency: A reason to screen.

#Shedding #Rotavirus
#Vaccine #Failure #Gastrointestinal
#MedScienceResearch

http://www.jacionline.org/article/S0091-6749(09)01565-6/abstract

🛑 Pertussis adjuvant prolongs intestinal hypersensitivity.

“CONCLUSIONS: Our findings indicate nanogram quantities of PT, when administered with a food protein, result in long-term sensitization to the antigen, and altered intestinal neuroimmune function. These data suggest that exposure to bacterial pathogens may prolong the normally transient immune responsiveness to inert food antigens.”

#Gastrointestinal #Food #Allergies #Autoimmunity #Pertussis #Vaccine #MedScienceResearch

http://www.ncbi.nlm.nih.gov/pubmed/10436392

Poliovirus Infections in Four Unvaccinated Children — Minnesota, August–October 2005

“On September 29, 2005, the Minnesota Department of Health (MDH) identified poliovirus type 1 in an unvaccinated, immunocompromised infant girl aged 7 months (the index patient) in an Amish community whose members predominantly were unvaccinated for polio. The patient has no paralysis; the source of the patient’s infection is unknown. Subsequently, poliovirus infections in three other children within the index patient’s community have been documented.”

“Partial sequencing of the virus capsid protein coding region (VP1) of the poliovirus genome at the MDH laboratory identified it as a vaccine-derived poliovirus (VDPV). VDPVs are poliovirus strains derived from one of the three Sabin poliovirus strains in oral polio vaccine (OPV) that have >1% difference in nucleotide sequence from the prototype vaccine virus.”

#Recently #Vaccinated #Shedding #Polio #Gastrointestinal #Vaccine #Failure #MedScienceResearch

https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5441a6.htm

🛑 A possible central mechanism in autism spectrum disorders, part 1.

“The autism spectrum disorders (ASD) are a group of related neurodevelopmental disorders that have been increasing in incidence since the 1980s. Despite a considerable amount of data being collected from cases, a central mechanism has not been offered. A careful review of ASD cases discloses a number of events that adhere to an immunoexcitotoxic mechanism. This mechanism explains the link between excessive vaccination, use of aluminum and ethylmercury as vaccine adjuvants, food allergies, gut dysbiosis, and abnormal formation of the developing brain. It has now been shown that chronic microglial activation is present in autistic brains from age 5 years to age 44 years. A considerable amount of evidence, both experimental and clinical, indicates that repeated microglial activation can initiate priming of the microglia and that subsequent stimulation can produce an exaggerated microglial response that can be prolonged. It is also known that one phenotypic form of microglia activation can result in an outpouring of neurotoxic levels of the excitotoxins, glutamate and quinolinic acid. Studies have shown that careful control of brain glutamate levels is essential to brain pathway development and that excesses can result in arrest of neural migration, as well as dendritic and synaptic loss. It has also been shown that certain cytokines, such as TNF-alpha, can, via its receptor, interact with glutamate receptors to enhance the neurotoxic reaction. To describe this interaction I have coined the term immunoexcitotoxicity, which is described in this article.”

#Autism #Immune #Aluminum
#Mercury #Food #Allergies
#Gastrointestinal
#Neurological #Vaccine #MedScienceResearch

http://www.ncbi.nlm.nih.gov/pubmed/19043938

Post-rotavirus vaccine intussusception in identical twins: A case report.

“Two infants aged 3 months, vaccinated against rotavirus. After about a week, one of the 2 identical infants presented inconsolable crying, vomiting, loose stools mixed with blood, and was diagnosed with bowel obstruction with intussusception. He was operated in urgency. After a few hours, his brother presented vomiting, and was admitted to our Hospital for suspected intussusception.”

#Rotavirus #Gastrointestinal #Intussusception #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/27070956/

Rectal Bleeding and Abdominal Pain Following Vaccination in a 4-Month-Old Infant.

#Gastrointestinal #Rotavirus #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/28163948

Risk of intussusception following rotavirus vaccination: An evidence based meta-analysis of cohort and case-control studies. (2017)

“RESULTS: Six cohort studies involving 4506265 total first doses and five case-control studies involving a total sample of 9643 children were included in this analysis. The cohort data revealed that there was an associated increased risk of intussusception after the first 7days post first dose of the vaccine (RR:3.71, 95% CI:1.08-12.69) and after receiving all doses of the rotavirus vaccine (RR:3.47, 95% CI:1.23-9.78). Similarly, the case-control data found an increased risk of intussusception following the first dose (OR: 8.45, 95% CI: 4.08-17.50) and following all doses (OR: 1.59, 95% CI: 1.11-2.27).

CONCLUSIONS: Findings of this meta-analysis suggest that the rotavirus vaccine is associated with an increased risk on the development of intussusception, principally seen after administration of the first dose of vaccine.”

#Rotavirus #Intussusception
#Gastrointestinal
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/28648544/

RotaTeq vaccine adverse events and policy considerations.

“RESULTS: From February 3, 2006 through July 31, 2007, a total of 160 (of the 165 reported) intussusception and 11 (of the 16 reported) Kawasaki disease adverse event reports were identified when RotaTeq was administered or co-administered with other vaccines. Time-trend analyses showed that there were significant increases in the total number of intussusception and Kawasaki disease adverse events entered into VAERS in comparison to previous years.

CONCLUSIONS: These observations, coupled with limited rotavirus disease burden, cost-effectiveness, and potential contact viral transmission concerns, raise serious questions regarding the use of RotaTeq in the US. Healthcare providers should diligently report adverse events following RotaTeq vaccination to VAERS, and those who have experienced a vaccine-associated adverse event should be made aware that they may be eligible for compensation from the no-fault National Vaccine Injury Compensation Program (NVICP).”

#Kawasaki #Rotavirus #Gastrointestinal
#Intussusception
#VAERS #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/18301365/

Rotavirus shedding in premature infants following first immunization.

#Shedding #Rotavirus #Failure #Gastrointestinal #Premature #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/21856359/

Rotavirus vaccine-derived shedding and viral reassortants.

#Shedding #Rotavirus #Failure #Gastrointestinal #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/23249230/

Rotavirus vaccines: viral shedding and risk of transmission.

#Shedding #Rotavirus #Failure #Vaccine #Gastrointestinal #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/18922486/

Severe combined immunodeficiency (SCID) and rotavirus vaccination: reports to the Vaccine Adverse Events Reporting System (VAERS).

“Stool rotavirus testing was positive in all cases and the virus was identified as the vaccine strain in six cases. Prolonged viral shedding was documented in five cases.”

#Shedding #Rotavirus
#Vaccine #Failure #Gastrointestinal
#VAERS #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/20674876/

Sibling transmission of vaccine-derived rotavirus (RotaTeq) associated with rotavirus gastroenteritis.

“Although rotavirus vaccines are known to be shed in stools, transmission of vaccine-derived virus to unvaccinated contacts resulting in symptomatic rotavirus gastroenteritis has not been reported to our knowledge. We document here the occurrence of vaccine-derived rotavirus (RotaTeq [Merck and Co, Whitehouse Station, NJ]) transmission from a vaccinated infant to an older, unvaccinated sibling, resulting in symptomatic rotavirus gastroenteritis that required emergency department care.”

#Unvaccinated #Shedding
#Vaccine #Failure #Gastrointestinal #Rotavirus #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/20100758/