Encephalomyelitis

Note: Also see category “ADEM” (Acute disseminated encephalomyelitis)

Acute disseminated encephalomyelitis associated with oral polio vaccine.

“A 27-year-old woman presented with acute paresis after taking an oral polio vaccine (OPV). Deep tendon reflexes were preserved, needle electromyography showed no neurogenic changes, and there were no lesions on spine magnetic resonance imaging (MRI), suggesting that motor neurons of the spinal cord were not affected. Brain MRI showed abnormal lesions in the tegmentum of the upper pons, left cerebral peduncles, truncus of the corpus callosum, and right parietal lobe. Cerebrospinal fluid revealed mild pleocytosis. The most probable diagnosis was acute disseminated encephalomyelitis associated with OPV.”

#ADEM #Polio #Neurological #Encephalomyelitis #Vaccine
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/17106158/

? Demyelinating disease and polyvalent human papilloma virus vaccination

“Since its inception, the polyvalent vaccine against the human papilloma virus (HPV), Gardasil, has generated some controversies as a temporal relationship between the administrations of the vaccine and the development of a few autoimmune diseases, such as acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS) and Guillain–Barre syndrome have been reported.1–3 We encountered two cases whose initial presentation of CNS demyelination followed in close time relationship the administration of Gardasil vaccine and we discuss their possible association.

Case No 1
A 19-year-old woman received two doses of Gardasil, 3 months apart, and approximately 1 month after the second dose, she developed numbness to the right foot that within 1 day extended to the contralateral foot and was associated with mid-thoracic back pain. Her neurological examination was only significant for the altered perception to touch to the feet. Deep tendon reflexes were normal and plantar reflexes in flexion. MRI of cervical and thoracic spine revealed a total of three lesions with characteristic demyelinating appearance, one of those in the thoracic spine was contrast-enhancing (figure 1A–C). MRI brain demonstrated one additional white matter lesion also consistent with a demyelinating process.”

#Gardasil #Vaccine
#Multiple #Sclerosis #HPV #Neurological
#Autoimmunity #ADEM
#Encephalomyelitis
#Guillain #Barre
#MedScienceResearch

http://jnnp.bmj.com/content/82/11/1296.long

Encephalomyelitis and bilateral optic perineuritis after influenza vaccination.

#Encephalomyelitis #Neurological #Ophthalmological #Vaccine #Influenza #Flu #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/11126677/

Idiopathic Parkinson’s disease(s) may follow subclinical episodes of perivenous demyelination.

“Three case studies of postvaccinal parkinsonism (PVP) demonstrated signs and symptoms identical to conventional diagnostic standards of idiopathic Parkinson’s disease (PD). PVP is a sub-type of acute disseminated encephalomyelitis (ADE) that also includes postinfectious parkinsonism (PIP) and postinfectious encephalomyelitis (PIE).”

#Parkinsons #Vaccine #ADEM #Neurological #Encephalomyelitis #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/12445523/

Post-vaccination encephalomyelitis: literature review and illustrative case.

#ADEM #Neurological
#Encephalomyelitis
#Rabies #Tetanus #Polio #Smallpox #MMR #DTP #Influenza
#Hepatitis B #Vaccine
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/18976924/

Semple rabies vaccine: presence of myelin basic protein and proteolipid protein and its activity in experimental allergic encephalomyelitis.

#Rabies #Vaccine #Neurological #Encephalomyelitis #Allergy #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/2480399/

Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus.

“We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.”

#Gardasil #Encephalomyelitis #ADEM #HPV #Neurological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140871/