Adverse events following quadrivalent meningococcal CRM-conjugate vaccine (Menveo®) reported to the Vaccine Adverse Event Reporting system (VAERS), 2010-2015.
Anaphylactic reactions to measles-mumps-rubella vaccine in three children with allergies to hen’s egg and cow’s milk.
“AIM: Allergies to hen’s egg and cow’s milk are the most frequent food allergies in infancy and childhood. Current guidelines recommend safe administration of measles-mumps-rubella (MMR) vaccine in egg allergic patients.
METHODS: We present three cases of anaphylaxis that we encountered after MMR vaccination in children sensitized to hen’s egg and cow’s milk.
RESULTS: Even though MMR vaccine is generally known to be safe in children with egg allergy, there may still be isolated cases of anaphylaxis.
CONCLUSION: Therefore, we recommend that all children not only those who were sensitized to foods should receive the MMR vaccination in a setting that is equipped to deal with anaphylactic reactions. As stated by WHO in immunization safety surveillance, ‘Each vaccinator must have an emergency kit with adrenaline, and be familiar with its dosage and administration’.
© 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.”
Anaphylactic shock due to vitamin K in a newborn and review of literature.
Anaphylaxis after zoster vaccine: Implicating alpha-gal allergy as a possible mechanism.
“Gelatin and other nonprimate mammal–derived products are common excipient ingredients in several vaccines, and it has been postulated that patients with alpha-gal allergy might react to these vaccines.”
Anaphylaxis following single component measles and rubella immunisation.
“Anaphylaxis as an adverse event following immunisation (AEFI) is a rare occurrence. We report four cases of anaphylaxis following administration of single component measles or rubella vaccine between January 2003 and June 2007. We estimate that the incidence of anaphylaxis to measles and rubella single component vaccines is 18.9 and 22.4 cases/100,000 doses, respectively. These figures are likely to be an underestimate but are higher than expected. Our calculations were hampered by lack of immunisation reporting data from the private sector. We recommend that NHS standards of vaccine data reporting are also applied to private clinics.”
Anaphylaxis in dogs and cats.
“Anaphylaxis may be triggered by a variety of antigens including insect and reptile venom, a variety of drugs, vaccines, and food.”
Food allergy to gelatin in children with systemic immediate-type reactions, including anaphylaxis, to vaccines.
? Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.
“After reviewing the literature, we observed that complications seen after Hepatitis B vaccination are sudden infant death syndrome, multiple sclerosis, chronic fatigue syndrome, idiopathic thrombocytopenic purpura, vasculititis optic neuritis, anaphylaxis, systemic lupus erytymatosus, lichen planus and neuro-muscular disorder.”
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Hypersensitivity reactions to human papillomavirus vaccine in Australian schoolgirls: retrospective cohort study.
“Thirteen (52%) experienced urticaria or angio-oedema, and of these, two experienced anaphylaxis.”
Lethal complications of typhoid-cholera-vaccination. (Case report and review of the literature).
“Simultaneous parenteral vaccination against typhoid and cholera lead to death through either anaphylactic shock or endotoxic shock in a 36-year-old male.”
Management of hypersensitivity reactions to anti-D immunoglobulin preparations.
Surveillance of adverse events after the first trivalent inactivated influenza vaccine produced in mammalian cell culture (Flucelvax(®)) reported to the Vaccine Adverse Event Reporting System (VAERS), United States, 2013-2015.
“Among 309 reports with an AE documented, 19 (6.1%) were serious and the most common categories were 152 (49.2%) general disorders and administration site conditions (mostly injection site and systemic reactions) and 73 (23.6%) immune system disorders with two reports of anaphylaxis. Four reports of GBS were submitted. Disproportional reporting was identified for ‘drug administered to patient of inappropriate age.'”
Vaccine-related adverse events in Cuban children, 1999-2008.
“The DTwP vaccine exhibited the highest rate of adverse events. Common minor events were: fever (17,538), reactions at injection site (4470) and systemic side effects (2422). Rare events (by WHO definition) reported were: persistent crying (2666), hypotonic-hyporesponsive episodes (3), encephalopathy (2) and febrile seizures (112). Severe events included: anaphylaxis (2), respiratory distress (1), multiple organ failure (1), sudden death (1), vaccine-associated paralytic poliomyelitis (2), toxic shock syndrome (3), and sepsis (1). The 10 deaths and 3 cases of disability were investigated by an expert commission, which concluded that 8 of the 13 severe events were vaccination-related.”