Also see the category, asthma .

Acute exacerbation of idiopathic pulmonary fibrosis after pandemic influenza A (H1N1) vaccination.

#Lung #Respiratory #H1N1 #Influenza #Flu #Vaccine #MedScienceResearch

Acute Lung Injury Accompanying Alveolar Hemorrhage Associated with Flu Vaccination in the Elderly.

#Lung #Respiratory #Influenza #Flu #Vaccine #MedScienceResearch

Adverse events following vaccination in premature infants.

“Apparent adverse events were noted in 17 of 45 (37.8%) babies: 9 (20%) had major events, i.e. apnoea, bradycardia or desaturations, and 8 (17.8%) had minor events, i.e. increased oxygen requirements, temperature instability, poor handling and feed intolerance. Babies with major events were significantly younger (p < 0.05), had a lower postmenstrual age (p < 0.05) and weighed less (p < 0.05) at the time of vaccination compared with babies without major events." "CONCLUSION: Vaccine-related cardiorespiratory events are relatively common in preterm babies. Problems were much more common if vaccine is administered at or before 70 d. These babies should therefore be monitored postvaccination." #Premature #Cardiorespiratory #Near #Miss #DTP #Hib #Bradycardia #Apnea #Respiratory #Cardiovascular #Vaccine #MedScienceResearch

[Allergic alveolitis after influenza vaccination]

#Respiratory #Vaccine #MedScienceResearch

Apnea after immunization of preterm infants.

“However, 12 (12%) infants experienced a recurrence of apnea, and 11 (11%) had at least a 50% increase in the number of apneic and bradycardic episodes in the 72 hours after immunization.”

#Premature #Cardiorespiratory #Near #Miss #DTP #Hib #Bradycardia #Apnea #Respiratory #Cardiovascular
#Vaccine #MedScienceResearch

🛑 Beta-tryptase and quantitative mast-cell increase in a sudden infant death following hexavalent immunization.

“A fatal case of a 3-month-old female infant, who died within 24 h of vaccination with hexavalent vaccine is presented. Clinical data, post-mortem findings (acute pulmonary oedema, acute pulmonary emphysema), quali-quantitative data collected from immunohistochemical staining (degranulating mast cells) and laboratory analysis with a high level of beta-tryptase in serum, 43.3 microg/l, allows us to conclude that acute respiratory failure likely due to post hexavalent immunization-related shock was the cause of death.”

#Sudden #Infant #Death #Syndrome #Vaccine #SIDS #Hexavalent #Respiratory

🛑 [Cardiorespiratory events after first immunization in premature infants: a prospective cohort study].

“OBJECTIVE: To investigate whether all preterm infants born before 33 weeks of gestation need cardiorespiratory monitoring due to the risk of cardiorespiratory disturbances following their first vaccination at 2 months of age.”

“In this cohort of 41 premature infants whose mean gestational age was 30.8 weeks (SD: 1.9), 10 of these had a mild decrease in oxygen saturation or bradycardia; three developed a moderate cardiorespiratory event requiring tactile stimulation.”

“It is recommended that still-hospitalized premature infants receive their first immunizations under cardiorespiratory monitoring, as events were observed during a period of 0-24 hours thereafter.”

#Premature #Cardiorespiratory
#Bradycardia #Near #Miss #Respiratory #Vaccine

[Case Report; Influenza vaccination-associated acute lung injury: two cases report].

#Lung #Respiratory #Influenza #Flu #Vaccine #MedScienceResearch

🛑 [Complications of pertussis immunization (author transl)].

“16 cases of neurological disease and/or death shortly after pertussis immunization are reported. Eight patients had convulsions, six with ensuing permanent defects. Severe polymyositis was observed in one case. Five infants died 12 h to 4 days after vaccination: two after acute encephalopathy and three in the form of a sudden unexpected death (SID). In two fatal cases the morphological changes in the brain corresponded to those of pertussis encephalopathy: neuronal degeneration in various parts of the cortex, especially in the region of the ammons horn, and in the cerebellum. There were no signs of inflammation. Three cases underwent forensic autopsy and death was attributed to bronchopulmonary infection. Complete neuropathological work-up was only done in one case, in which the brain was normal. The critique of episodical reports and the demand for prospective studies is appreciated. Knowledge of all possible forms of complications, however, is indispensable for future investigations. Polymyositis and SID have so far not been listed as abnormal reactions to immunization. The majority of our cases became known accidentally from hospital sheets or from discussions with collegues. For a detection of all possible cases a greater awareness of doctors for the problem of pertussis immunization appears necessary. Only another 23 cases have been reported to the health authorities of the state of Lower Saxony during the last 6 to 7 years. Of those, nine were either harmless reactions or diseases probably unrelated to vaccination. Two were cases of SID, 12 and 72 h after vaccination. It is concluded that only a minor proportion of possible complications is presently reported to the health authorities.”

#Sudden #Infant #Death #Syndrome #SIDS #Pertussis #Neurological #Seizures #Encephalopathy
#Respiratory #Vaccine

Deaths Reported to the Vaccine Adverse Event Reporting System, United States, 1997-2013.

#Death #SIDS #Influenza #Flu #Respiratory #Vaccine #MedScienceResearch

Delayed life-threatening reaction to anthrax vaccine.

“CASE REPORT: We report a delayed and potentially serious life-threatening adverse reaction to anthrax vaccine. A previously healthy 34-year-old male was transported to the emergency department with dyspnea, diaphoresis, pallor, and urticarial wheals on his face, arms, and torso after the administration of the third dose of anthrax vaccine. All symptoms resolved after pharmacological intervention and the patient was discharged. Pharmaco-epidemiological data indicate that 30% of anthrax vaccine recipients experience mild local reactions. With large numbers of military personnel being vaccinated, emergency physicians may encounter more vaccine-related adverse reactions.”

#Anthrax #Dermatological #Respiratory #Vaccine

Fatal adult respiratory distress syndrome in a scalded child after immunization with attenuated virus (measles, mumps and rubella).

“A fatal adult respiratory distress syndrome (ARDS) occurred in a 15-month-old child who had suffered minor scalding during the febrile response to combined attenuated virus immunization (measles, mumps and rubella [MMR]). Despite vigorous efforts the child died 26 days after the accident. It is suggested that the scalding suppressed the normal immune response to the viremia and that the latter (i.e. most likely the measles viremia) caused the lung damage which, in turn, led to the ARDS.”

#Death #MMR #Measles #Vaccine
#Respiratory #MedScienceResearch

🛑 Imported Vaccine-Associated Paralytic Poliomyelitis — United States, 2005

“This report describes the first known occurrence of imported VAPP in an unvaccinated U.S. adult who traveled abroad, where she likely was exposed through contact with an infant recently vaccinated with OPV.”

“Upon admission to a hospital in Phoenix, the patient had bilateral areflexic lower extremity weakness and respiratory failure requiring intubation.”

“The host family’s son and daughter-in-law lived next door with two children, aged 2 months and 3 years, who visited the host family frequently. The infant received his first dose of OPV on January 19, 2005, 4 days after the woman arrived to live with the host family.”

#Recently #Vaccinated #Shedding
#Polio #Paralysis
#Neurological #Respiratory
#Vaccine #MedScienceResearch

Incidence of apnoea and bradycardia in preterm infants following triple antigen immunization.

“Ninety-seven preterm infants were immunized with diphtheria-tetanus-pertussis (DTP) prior to discharge from hospital. The mean gestational age at birth was 28.1 weeks (range 24-34) and the mean age at immunization was 80.6 days (range 44-257). Nineteen (20%) infants developed apnoea or bradycardia within 24 h of immunization. The infants who developed apnoea and/or bradycardia had a younger gestational age at birth than those who did not (P = 0.03), were artificially ventilated for longer (P = 0.01) and were more likely to have a diagnosis of chronic lung disease (P = 0.006). In the majority of infants these events were not clinically significant. Two infants who developed concurrent upper respiratory tract infections required additional oxygen and one of them was treated with oral theophylline. In general, it is safe practice to immunize preterm infants with DTP unless otherwise contraindicated. However, it is recommended that cardiorespiratory function is monitored after immunization in very preterm infants who had prolonged ventilatory support and/or chronic lung disease.”

#Cardiorespiratory #Premature #Apnea #Near #Miss #DTP
#Bradycardia #Cardiovascular
#Respiratory #Vaccine #MedScienceResearch

Influenza vaccine-induced interstitial lung disease.

#Lung #Influenza #Flu #Respiratory #Vaccine #MedScienceResearch

Interstitial Pneumonia Associated with the Influenza Vaccine: A Report of Two Cases.

#Pneumonia #Influenza #Flu #Vaccine #MedScienceResearch

Lung pathology and immediate hypersensitivity in a mouse model after vaccination with pertussis vaccines and challenge with Bordetella pertussis.

#Lung #Respiratory #DTaP #Vaccine #MedScienceResearch

Mycobacterium bovis lymphadenitis complicating BCG immunization in an infant with symptomatic HIV-1 infection.

“A 3-month-old infant with HIV-1 infection who recently immigrated from Ethiopia developed regional lymphadenitis and systemic symptoms subsequent to BCG immunization. She was suffering from axillary lymphadenitis ipsilateral to the BCG vaccination site, failure to thrive, unresolving fever and hepatosplenomegaly. Acid-fast bacilli were seen on staining and Mycobacterium bovis was isolated from the regional lymph node. The infant responded promptly to triple antituberculous therapy but died 2 months later from overwhelming pneumonia and respiratory failure. This case emphasizes the iatrogenic hazards of BCG immunization in HIV-1 infected infants. With the increasing prevalence of pediatric HIV-1 infection, indiscriminate BCG immunization programs should be reconsidered. While infants with asymptomatic HIV-1 infection at risk for tuberculosis should be immunized, BCG immunization should be withheld in those with symptomatic disease.”

#BCG #Respiratory #Pneumonia #Vaccine #MedScienceResearch

Neonatal paralytic poliomyelitis. A case report.

“We report a child who became symptomatic with apnea at 18 days of age and who subsequently developed a permanent monoparesis. Serologic and cultural evidence indicated the virus as poliovirus vaccine type. Another infant who received live oral poliovirus vaccine was probably the source of the infecting virus.”

#Shedding #Polio
#Recently #Vaccinated #Paralysis #Apnea #Respiratory
#Vaccine #Failure

A Pneumonia Case Associated with Type 2 Polio Vaccine Strains.

#Polio #Vaccine #Failure #Pneumonia #Respiratory #MedScienceResearch;year=2017;volume=130;issue=1;spage=111;epage=112;aulast=Li

Possible predictors of cardiorespiratory events after immunization in preterm neonates.

“Immunization was performed on 31 very preterm infants [28 weeks’ gestation (26.9-29), birth weight: 965 g (795-1,105)], and was associated with an increased incidence (p < 0.01) of events lasting more than 10 s: bradycardia <80 bpm [2.2 (1.1-7) vs. 1.8 (1-4)/12 h], desaturation [17.6 (9.4-36.4) vs. 13.9 (7.7-33.8)/12 h] and associated bradycardia-desaturation [IB+D, 4.1 (1.4-7.3) vs. 2.4 (1-4.6)/12 h], with mild changes in HRV and no change in RRV." "The increase in CR events after the first immunization in very preterm infants was associated with: (1) sympathetic predominance in heart rate control (high LF/HF ratio), (2) abnormal oversimplification of HRV (low entropy) and (3) persistent respiratory rhythm control immaturity (high IB+D before vaccine)." #Cardiorespiratory #Premature #Respiratory #Bradycardia #Cardiovascular #Vaccine #MedScienceResearch

Potential risk of repeated nasal vaccination that induces allergic reaction with mucosal IgE and airway eosinophilic infiltration in cynomolgus macaques infected with H5N1 highly pathogenic avian influenza virus.

“On the other hand, eosinophil clusters were observed in the lungs of vaccinated macaques. Although Vac-3-specific IgE antibody and IL-13 levels were decreased after infection compared to those before infection and no anaphylaxis in vaccinated macaques was detected after challenge infection, our results suggest that we have to pay attention to potential allergic responses at repeated nasal vaccination, especially in people who have an airway allergy.”

#Respiratory #Lung #Allergies #Eosinophil #Influenza #Flu #Vaccine #MedScienceResearch

Recurrence of cardiorespiratory events following repeat DTaP-based combined immunization in very low birth weight premature infants.

#DTaP #Respiratory #Cardiovascular #Vaccine #Premature #MedScienceResearch

Vaccine-related adverse events in Cuban children, 1999-2008.

“The DTwP vaccine exhibited the highest rate of adverse events. Common minor events were: fever (17,538), reactions at injection site (4470) and systemic side effects (2422). Rare events (by WHO definition) reported were: persistent crying (2666), hypotonic-hyporesponsive episodes (3), encephalopathy (2) and febrile seizures (112). Severe events included: anaphylaxis (2), respiratory distress (1), multiple organ failure (1), sudden death (1), vaccine-associated paralytic poliomyelitis (2), toxic shock syndrome (3), and sepsis (1). The 10 deaths and 3 cases of disability were investigated by an expert commission, which concluded that 8 of the 13 severe events were vaccination-related.”

#Death #DTP #Seizures #HHE #Encephalopathy #Polio #Respiratory #Anaphylaxis #Neurological #Vaccine #Failure #MedScienceResearch