Adjuvant activity of a novel metabolizable lipid emulsion with inactivated viral vaccines.
“The lipid base consists of highly refined peanut oil emulsified in aqueous vaccines with glycerol and lecithin.”
Antibody response in man to Hong Kong influenza following 1967 formula influenza vaccine in adjuvant 65.
“The adjuvant preparation consists of a water-in- peanut oil emulsion of the aqueous vaccine, employing mannide monooleate (Arlacel A) as emulsifier and aluminum monostearate as stabilizer.”
Comparison of tissue reactions produced by Haemophilus pleuropneumoniae vaccines made with six different adjuvants in swine.
“Tissue damage caused by six different adjuvants incorporated in a Haemophilus pleuropneumoniae vaccine was compared in swine. The adjuvants compared were four mineral oil compounds, one peanut oil compound and aluminum hydroxide.”
Experimental thyroid autoimmunity in the dog.
“Thyroid autoimmunity was induced in 6 crossbred dogs by a single injection of thyroid extract in complete Freund’s adjuvant alone, or followed by reimmunization with thyroid extract and incomplete Freund’s adjuvant or peanut oil.”
Hyperpotentiation by Synthetic Double-Stranded RKA of Antibody Responses to Influenza Virus Vaccine in Adjuvant 65 (33983)
“The adjuvant preparation consisted of a water-in-peanut oil emulsion of the aque- ous vaccine employing mannide monooleate(Arlacel A) as emulsifier and aluminum mo- nostearate as stabilizer.”
Increase of immune response by administration of metabolizable vegetable oil emulsions
“The present study describes the conditions under which a stable water in oil emulsion can be produced by using metabolizable peanut oil with arlacel. When mycobacteria are added, a potent emulsified oil adjuvant is obtained which increases the immune response to BSA and to influenza vaccine.”
Response to influenza vaccine in adjuvant 65-4.
“A comparison was made of the antibody response and subjective reactions to zonally-purified influenza vaccine in aqueous suspension and in peanut oil adjuvant 65-4.”
Ten-Year Follow-Up Study for Safety of Adjuvant 65 Influenza Vaccine in Man (37469)
“The earlier adjuvant 65 influenza vaccine consist- ed of a water-in-oil emulsion of influenza vi- rus vaccine in peanut oil employing Arlacel A (mannide monooleate) as emulsifier and aluminum monostearate as stabilizer.”
Peanut oil in Bacillus Calmette–Guérin (BCG) vaccine
Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil.
“The influence of mineral oil, squalane, squalene, or peanut oil on the antitumor activity of emulsified Bacillus Calmette-Guérin cell walls or emulsified trehalose-6,6′-dimycolate was studied in mice, each with an established transplant of a syngeneic fibrosarcoma.”