Acute Disseminated Encephalomyelitis After Influenza Vaccination: A Case Report

“Acute disseminated encephalomyelitis developed in a 42-year-old woman within 3 weeks of receiving the seasonal influenza vaccine. She had 80% recovery after 3 months of treatment with methylprednisolone. Although cases of acute disseminated encephalomyelitis after vaccination for influenza are rare, enough of them have occurred that critical care nurses should be aware of the possibility. Early treatment can prevent serious residual signs and symptoms; therefore, correct and quick diagnosis is important. Medical history obtained from patients with central nervous system problems should include history of recent vaccinations.”

#ADEM #Encephalomyelitis #Neurological #Influenza #Flu #Vaccine #MedScienceResearch

🛑 [Acute disseminated encephalomyelitis after tetanus vaccination of a pregnant woman in Senegal].

Although neurological complications have been described after tetanus vaccinations, they are rare. The authors report a case of acute disseminated encephalomyelitis (ADEM) in a 28-year-old pregnant woman at a gestational age of 10 weeks, admitted 15 days after a tetanus vaccination, with spastic tetraplegia and sphincter disturbances. Corticosteroid treatment led to partial recovery of the neurological deficit. Differential diagnosis of infectious and demyelinating diseases of the central nervous system is difficult in view of clinical and laboratory aspects of post-vaccination ADEM. Without any specific diagnostic markers, the clinical examination, magnetic resonance imaging and negative etiological findings were key to this diagnosis. Medical staff must bear in mind the possible complications of this vaccine.

#Pregnancy #ADEM #Tetanus #Vaccine #Neurological

Acute disseminated encephalomyelitis associated with oral polio vaccine.

“A 27-year-old woman presented with acute paresis after taking an oral polio vaccine (OPV). Deep tendon reflexes were preserved, needle electromyography showed no neurogenic changes, and there were no lesions on spine magnetic resonance imaging (MRI), suggesting that motor neurons of the spinal cord were not affected. Brain MRI showed abnormal lesions in the tegmentum of the upper pons, left cerebral peduncles, truncus of the corpus callosum, and right parietal lobe. Cerebrospinal fluid revealed mild pleocytosis. The most probable diagnosis was acute disseminated encephalomyelitis associated with OPV.”

#ADEM #Polio #Neurological #Encephalomyelitis #Vaccine

Acute Disseminated Encephalomyelitis Following Immunization with Human Papillomavirus Vaccines.

#Gardasil #Neurological #ADEM #Encephalomyelitis #HPV #Molecular #Mimicry #Vaccine #MedScienceResearch

Acute disseminated encephalomyelitis following inactivated influenza vaccination in the Brazilian Amazon: a case report

“Here, we describe a case of acute disseminated encephalomyelitis (ADEM) that occurred during a plausible risk interval following inactivated influenza vaccination in a previously healthy 27-year-old man from Manaus, Brazil. He was treated with intravenous methylprednisolone and immunoglobulin. One-month follow-up revealed resolution of the brain lesions, but not of the spinal cord lesions. No recurrence or progression of the main neurological symptoms was observed. After two years of monitoring, the patient continues to experience weak lower limbs and urinary retention. Thus, we recommend that ADEM should be considered in a patient presenting with neurological symptoms after influenza vaccination.”

#ADEM #Influenza #Flu #Encephalomyelitis #Neurological #Vaccine #MedScienceResearch

[Acute disseminated encephalomyelitis following influenza vaccination: report of a case with callosal disconnection syndrome].

#Encephalomyelitis #ADEM
#Influenza #Flu #Vaccine
#Neurological #MedScienceResearch

Acute Disseminated Encephalomyelitis following Vaccination against Hepatitis B in a Child: A Case Report and Literature Review

“Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system, which has been associated with several vaccines such as rabies, diphtheria-tetanus-polio, smallpox, measles, mumps, rubella, Japanese B encephalitis, pertussis, influenza, and the Hog vaccine. Here, we presented a case of 12-year-old child who suffered from ADEM three weeks after hepatitis B vaccination. He was admitted to our hospital with symptoms of weakness of limbs, high fever, and alteration of consciousness. Some abnormalities were also found in CSF. Treatment with high-dose corticosteroids and intravenous immunoglobulin had significant effect, with marked improvement of the clinical symptoms and the results of CSF. The findings of MRI also detected some abnormal lesions located in both brain and spinal cord. The clinical features, the findings of CSF and MRI, and therapeutic effect may contribute to such diagnosis of ADEM.”

#ADEM #Neurological #Encephalomyelitis #Hepatitis B #Vaccine #MedScienceResearch

Acute disseminated encephalomyelitis secondary to serogroup B meningococcal vaccine

“•Acute disseminated encephalomyelitis (ADEM) is rare in adults.
•This is the first published case of ADEM secondary to serogroup B meningococcal vaccine.
•Vaccination must be considered in the differential diagnosis of ADEM.”

#ADEM #Neurological #Encephalomyelitis
#Meningococcal #Vaccine #MedScienceResearch

Acute flaccid paralysis surveillance indicators in the Democratic Republic of Congo during 2008-2014.

“Of the 13,749 AFP cases investigated, 58.9% received at least three doses of oral polio vaccine (OPV), 7.3% never received OPV, while the status of 18.3% was unknown.”

#Polio #Paralysis #Neurological
#Vaccine #Failure #MedScienceResearch

[Acute maternal anterior poliomyelitis in a non-endemic zone].

“The authors report the case of a 26 year old woman with acute anterior poliomyelitis contracted during the vaccination of her baby. Despite having been herself vaccinated in infancy she was not protected against the poliovirus. The clinical interest of this uncommon case is a severe paralytic state with definitive paraplegia.”

#Recently #Vaccinated #Shedding
#Polio #Paralysis #Neurological #Vaccine #MedScienceResearch

Acute Onset of Parkinsonism With Reversible Course After H1N1 Vaccination: Insight From a Young Lady

“To the Editor: Parkinsonian symptoms can be induced by acute encephalitis, syphilis, malaria, poliomyelitis, and sudden carbon monoxide poisoning.1,2 In this report, a 17-year-old girl had Parkinson’s disease (PD) symptoms after a flu shot. So far, this is the first vaccine-related disorder that mimics PD. Our experience has shown that some parkinsonism can be cured with accurate diagnosis and appropriate treatment.”

#Parkinsonism #Neurological #Flu #Influenza #H1N1 #Vaccine #MedScienceResearch

Acute transverse myelitis following vaccination against H1N1 influenza: a case report.

#Transverse #Myelitis #Influenza #Flu #Vaccine #H1N1 #Neurological #MedScienceResearch

[Acute transverse myelitis secondary to hepatitis B vaccination].

#Transverse #Myelitis #Autoimmunity #Hepatitis B #Vaccine #Neurological #MedScienceResearch

Adjuvants- and vaccines-induced autoimmunity: animal models.

“In some cases, adjuvants may trigger generalized autoimmune response, resulting in multiple auto-antibodies, but sometimes they can reproduce human autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, autoimmune thyroiditis and antiphospholipid syndrome and may provide insights about the potential adverse effects of adjuvants.”

#Thyroid #Arthritis #Lupus #Sjogren #Autoimmunity #Antiphospholipid #Animals #Veterinary #Musculoskeletal #Neurological #Vaccine

Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes.

#Aluminum #Neurological #Vaccine #MedScienceResearch

Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate.

#Neurological #Thimerosal #Neurodevelopmental #Mercury #Vaccine #MedScienceResearch

🛑 Adverse effect versus quality control of the Fuenzalida-Palacios antirabies vaccine. 

“We evaluated the components of the Fuenzalida-Palacios antirabies vaccine, which is till used in most developing countries in human immunization for treatment and prophylaxis. This vaccine is prepared from newborn mouse brains at 1% concentration. Even though the vaccine is considered to have a low myelin content, it is not fully free of myelin or of other undesirable components that might trigger adverse effects after vaccination. The most severe effect is a post-vaccination neuroparalytic accident associated with Guillain-BarrĂ© syndrome. In the present study we demonstrate how the vaccinesproduced and distributed by different laboratories show different component patterns with different degrees of impurity and with varying protein concentrations, indicating that production processes can vary from one laboratory to another. These differences, which could be resolved using a better quality control process, may affect and impair immunization, with consequent risks and adverse effects after vaccination. We used crossed immunoelectrophoresis to evaluate and demonstrate the possibility of quality control in vaccine production, reducing the risk factors possibly involved in these immunizing products.”

#Contamination #MouseBrain #Guillain #Barre #Neurological #Rabies #Vaccine #Error #Molecular #Mimicry #MedScienceResearch

Adverse events following Haemophilus influenzae type b vaccines in the Vaccine Adverse Event Reporting System, 1990-2013.

“Includes 29 747 reports after Hib vaccines; 5179 (17%) were serious, including 896 reports of deaths. Median age was 6 months (range 0-1022 months). Sudden infant death syndrome was the stated cause of death in 384 (51%) of 749 death reports with autopsy/death certificate records.”

#SIDS #Death #Sudden #Infant #Death #Syndrome #Hib #VAERS #Gastrointestinal #Neurological #Vaccine #MedScienceResearch

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.

#Gulf #War #Syndrome #Aluminum #ALS #Anthrax #Neurological #Vaccine #MedScienceResearch

Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine.

#Rabies #Paralysis #Neurological #Vaccine #MedScienceResearch


“Antirabies vaccines produced from infected brains of adult mammals have always had the potentiality of causing post-vaccinal paralysis or allergic encephalitis in man. Attempts in recent years either to remove the paralytic factor from brain-tissue vaccines or to use as the virus source infected tissue other than nervous tissue (e.g., chick embryos) have usually resulted in a substantial reduction of the specific antirabies potency.”

#Rabies #Paralysis #Neurological #Encephalitis #Vaccine #MedScienceResearch

An assessment of thimerosal use in childhood vaccines.

“Limited data on toxicity from low-dose exposures to ethylmercury are available, but toxicity may be similar to that of methylmercury. Chronic, low-dose methylmercury exposure may cause subtle neurologic abnormalities.”

#Thimerosal #Mercury #Neurological #Vaccine #MedScienceResearch

Association of acute cerebellar ataxia and human papilloma virus vaccination: a case report.

“INTRODUCTION: We report the case of a patient who developed symptoms of acute cerebellar ataxia (ACA) after administration of the human papilloma virus (HPV)-16/18 vaccine.

PATIENT AND METHOD: This patient developed symptoms of ACA, including nausea, vertigo, severe limb and truncal ataxia, and bilateral spontaneous continuous horizontal nystagmus with irregular rhythm, 12 days after administration of the HPV-16/18 AS04-adjuvanted cervical cancer vaccine. After this, the patient received methylprednisolone pulse and intravenous immunoglobulin (IVIG) therapies as well as immunoadsorption plasmapheresis.

RESULTS: Severe ACA symptoms did not improve after methylprednisolone pulse and IVIG therapies, but the patient recovered completely after immunoadsorption plasmapheresis.

CONCLUSION: This temporal association strongly suggests that ACA was induced by the vaccination.”

#Gardasil #Neurological #HPV #Ophthalmological #Eyes
#Vaccine #MedScienceResearch

Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep.

#Animal #ASIA #Autoimmunity #Veterinary #Neurological #Aluminum #Vaccine #MedScienceResearch

Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil.

#Gardasil #HPV #Depression #Autoimmunity #Neurological
#Vaccine #MedScienceResearch

Bell’s palsy as a possible complication of hepatitis B vaccination in a child.

#Bells #Palsy #Hepatitis B #Neurological #Vaccine #MedScienceResearch

Benign recurrent abducens (sixth) nerve palsy.

#Neurological #Eyes #Vaccine #MedScienceResearch

A case-control study of quadrivalent human papillomavirus vaccine-associated autoimmune adverse events.

“It was observed that cases with the SAAE outcomes of gastroenteritis (odds ratio (OR) = 4.6, 95% confidence interval (CI) = 1.3-18.5), arthritis (OR = 2.5, 95% CI = 1.4-4.3), systemic lupus erythematosus (OR = 5.3, 95% CI = 1.5-20.5), vasculitis (OR = 4, 95% CI = 1.01-16.4), alopecia (OR = 8.3, 95% CI = 4.5-15.9), or CNS conditions (OR = 1.8, 95% CI = 1.04-2.9) were significantly more likely than controls to have received HPV4 vaccine (median onset of SAAE symptoms from 6 to 55 days post-HPV4 vaccination).”

#Gardasil #Lupus #Arthritis #Autoimmunity #HPV #Hair #Loss
#Gastrointestinal #Alopecia #Neurological #Vaccine #MedScienceResearch

[A case of Guillain-Barré syndrome following cholera vaccination (author’s transl)].

“A 45-year-old woman developed bilateral ascending flaccid paralysis after cholera vaccination, 15 days after the first and 1 day after the second injection. The clinical course resulted in nearly complete paralysis of the lower limbs, paresis of the upper limbs and partial involvement of the cranial nerves. There was only slight sensory loss. The CSF revealed no pleocytosis and a protein level of 206 mg/100 ml. Recovery began 2 weeks later and was almost complete after 2 months. Immunological investigations revealed no remarkable changes.”

#Guillain #Barre #Paralysis #Neurological #Cholera #Vaccine #MedScienceResearch

A Case Report of Post Rabipur (Purified Chick Embryo Rabies Vaccine) Acute Disseminated Encephalomyelitis.

“Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease that typically occurs following a viral infection or vaccination. The incidence of ADEM following vaccination has become very low since introduction of non-neural rabies vaccine and only few cases had been reported due to pure chick embryo derived rabies vaccine (PCERV). Here we are reporting a rare case of delayed post vaccinal ADEM.”

#Rabies #ADEM #Encephalomyelitis #Neurological #Vaccine #MedScienceResearch

🛑 Case report of post sheep brain rabies vaccine neuroparalytic complications at Tikur Anbessa Teaching Hospital, in Ethiopia.

“We report four cases of ascending paralysis admitted to Tikur Anbessa Specialized Hospital (TASH) within six months period between December 2010 and June 2011 following administration of sheep brain tissue anti rabies vaccine for presumed rabies exposure. The paralysis started after a minimum of twelve doses of the vaccine. Two of the patients were discharged with severe paralysis and two died in the hospital.”

#Death #Rabies #Paralysis #Vaccine #Neurological #MedScienceResearch

CNS demyelination and quadrivalent HPV vaccination.

“Vaccination is generally considered safe in patients with multiple sclerosis (MS). We report five patients who presented with multifocal or atypical demyelinating syndromes within 21 days of immunization with the quadrivalent human papilloma virus (HPV) vaccine, Gardasil. Although the target population for vaccination, young females, has an inherently high risk for MS, the temporal association with demyelinating events in these cases may be explained by the potent immuno-stimulatory properties of HPV virus-like particles which comprise the vaccine. A prospective case-control study of patients with MS or clinically isolated demyelinating syndromes receiving the Gardasil vaccine may provide relevant safety data in this population.”

#Multiple #Sclerosis #MS #Gardasil #HPV #Neurological #Vaccine #MedScienceResearch

🛑 [Complications of pertussis immunization (author transl)].

“16 cases of neurological disease and/or death shortly after pertussis immunization are reported. Eight patients had convulsions, six with ensuing permanent defects. Severe polymyositis was observed in one case. Five infants died 12 h to 4 days after vaccination: two after acute encephalopathy and three in the form of a sudden unexpected death (SID). In two fatal cases the morphological changes in the brain corresponded to those of pertussis encephalopathy: neuronal degeneration in various parts of the cortex, especially in the region of the ammons horn, and in the cerebellum. There were no signs of inflammation. Three cases underwent forensic autopsy and death was attributed to bronchopulmonary infection. Complete neuropathological work-up was only done in one case, in which the brain was normal. The critique of episodical reports and the demand for prospective studies is appreciated. Knowledge of all possible forms of complications, however, is indispensable for future investigations. Polymyositis and SID have so far not been listed as abnormal reactions to immunization. The majority of our cases became known accidentally from hospital sheets or from discussions with collegues. For a detection of all possible cases a greater awareness of doctors for the problem of pertussis immunization appears necessary. Only another 23 cases have been reported to the health authorities of the state of Lower Saxony during the last 6 to 7 years. Of those, nine were either harmless reactions or diseases probably unrelated to vaccination. Two were cases of SID, 12 and 72 h after vaccination. It is concluded that only a minor proportion of possible complications is presently reported to the health authorities.”

#Sudden #Infant #Death #Syndrome #SIDS #Pertussis #Neurological #Seizures #Encephalopathy
#Respiratory #Vaccine

A comprehensive review of mercury provoked autism

#Autism #Mercury #Neurological #Sensory #Immune #Vaccine #MedScienceResearch

Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis.

“Notwithstanding this, we describe here devastating neurological complications associated with the detection of live-attenuated mumps virus Jeryl Lynn (MuV(JL5)) in the brain of a child who had undergone successful allogeneic transplantation for severe combined immunodeficiency (SCID). This is the first confirmed report of MuV(JL5) associated with chronic encephalitis and highlights the need to exclude immunodeficient individuals from immunisation with live-attenuated vaccines.”

#MMR #Mumps #Vaccine #Failure #Encephalitis #Neurological

🛑 Demyelinating disease and polyvalent human papilloma virus vaccination

“Since its inception, the polyvalent vaccine against the human papilloma virus (HPV), Gardasil, has generated some controversies as a temporal relationship between the administrations of the vaccine and the development of a few autoimmune diseases, such as acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS) and Guillain–Barre syndrome have been reported.1–3 We encountered two cases whose initial presentation of CNS demyelination followed in close time relationship the administration of Gardasil vaccine and we discuss their possible association.

Case No 1
A 19-year-old woman received two doses of Gardasil, 3 months apart, and approximately 1 month after the second dose, she developed numbness to the right foot that within 1 day extended to the contralateral foot and was associated with mid-thoracic back pain. Her neurological examination was only significant for the altered perception to touch to the feet. Deep tendon reflexes were normal and plantar reflexes in flexion. MRI of cervical and thoracic spine revealed a total of three lesions with characteristic demyelinating appearance, one of those in the thoracic spine was contrast-enhancing (figure 1A–C). MRI brain demonstrated one additional white matter lesion also consistent with a demyelinating process.”

#Gardasil #Vaccine
#Multiple #Sclerosis #HPV #Neurological
#Autoimmunity #ADEM
#Guillain #Barre

[Demyelinating disease and vaccination of the human papillomavirus].

“CASE REPORTS: We describe the cases of four young women that developed demyelinating disease after the vaccination of the HPV, with a rank of time between the administration of the dose and the development of the clinical of seven days to a month, with similar symptoms with the successive doses. We have described six episodes coinciding after the vaccination.

CONCLUSIONS: Have been described seizures, autoimmune disorders such as Guillain-Barre syndrome, transverse myelitis, or motor neuron disease, probably adverse effects following immunization by HPV vaccine. So we suggest that vaccine may trigger an immunological mechanism leading to demyelinating events, perhaps in predisposed young.”

#Gardasil #Neurological #Seizures
#Autoimmunity #HPV
#Guillain #Barre
#Transverse #Myelitis
#Immune #Vaccine

Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?

#Autism #Aluminum #Vaccine #MedScienceResearch #Neurological

A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders.

#Neurodevelopmental #Neurological #Mercury #Vaccine #MedScienceResearch

Encephalitis related to a H1N1 vaccination: case report and review of the literature.

“RESULTS: We report a case of a 26-year-old female who developed symptoms of acute encephalitis 5 days after vaccination against the pandemic 2009 A/H1N1 influenza. MRI of the brain showed confluent T2-hyperintense signal intensity changes in the deep white matter which further confirmed the diagnosis of encephalitis/acute disseminated encephalomyelitis. Despite therapy with immunoglobulins and corticosteroids, her persistent vegetative state continued. In light of the dramatic cause of this case, we reviewed all 21 other previously reported cases of central nervous system demyelination related to H1N1 vaccination and/or infection.

CONCLUSIONS: The available data suggest that even severe central nervous system demyelination i.e. acute encephalitis/disseminated encephalomyelitis and transverse myelitis may very rarely be associated with vaccination against novel influenza A/H1N1 or with A/H1N1 infection itself.”

#H1N1 #Encephalitis #Influenza #Flu #Neurological
#Vaccine #MedScienceResearch

Encephalomyelitis and bilateral optic perineuritis after influenza vaccination.

#Encephalomyelitis #Neurological #Ophthalmological #Vaccine #Influenza #Flu #MedScienceResearch

🛑 Estimating the extent of vaccine-derived poliovirus infection.

“Eight outbreaks of paralytic polio attributable to circulating vaccine-derived poliovirus (cVDPV) have highlighted the risks associated with oral poliovirus vaccine (OPV) use in areas of low vaccination coverage and poor hygiene.”

“Although only 114 virologically-confirmed paralytic cases were identified in the eight cVDPV outbreaks, it is likely that a minimum of hundreds of thousands, and more likely several million individuals were infected during these events, and that many thousands more have been infected by VDPV lineages within outbreaks which have escaped detection.”

#Shedding #Vaccine #Failure #Polio #Acute #Flaccid #Paralysis #Neurological #MedScienceResearch

Experimental scoliosis in primates: a neurological cause.

#Scoliosis #Vaccine #Neurological #Polio #Musculoskeletal

“A series of monkeys is presented where scoliosis developed incidentally during the routine virulence testing of live, attenuated, oral poliomyelitis vaccines by intraspinal injection.”

Extensive myelitis after oral polio vaccination: MRI features.

#Myelitis #Polio #Ataxia #Neurological #Vaccine #MedScienceResearch

Fatal Myelitis after Antirabic Vaccine

#Death #Rabies #Neurological #Vaccine #MedScienceResearch

[Fatal outcome after postexposure rabies vaccination in a patient with Parkinson’s disease].

#Parkinsons #Death #Vaccine #Rabies #Neurological #MedScienceResearch

Fetal damage after accidental polio vaccination of an immune mother.

“Irreparable damage to the anterior horn cells of the cervical and thoracic cord was found in a 20-week-old fetus whose mother was immune to poliomyelitis before conceiving but who was inadvertently given oral polio vaccine at 18 weeks gestation. Polio neutralizing antibody titres in sera, taken before and after pregnancy, were identical and were at levels normally regarded as providing protection. Unsuccessful attempts were made to isolate poliovirus from extracts of fetal brain, lung, liver and placenta. Fluorescent antibody tests were performed on various levels of the central nervous system and on the left and right extensor forearm muscles. Specific positive fluorescence to poliovirus 2 and 3 antigens was detected at dorsal spinal cord level only. One positive result was seen with Coxsackie A9 antiserum and fresh guinea-pig complement in the inflammatory cells in the right extensor forearm muscles.This experience, as yet unexplained, underlines the importance of ensuring that women are not pregnant prior to oral polio vaccination.”

#Error #Pregnancy #Polio #Neurological #Vaccine

🛑 Guillain-Barré Syndrome after H1N1 Shot in Pregnancy: Maternal and Fetal Care in the Third Trimester-Case Report.

“We presented a case of a 36-year-old pregnant woman that was immunized to H1N1 in the last trimester; 10 days later she developed shoulder and lumbar spine’s pain, limbs weakness and facial paralysis with unfavorable clinical evolution and was submitted to intensive therapy care. We described clinical and obstetrical approach, pointing out peculiarities involved in this pathology in pregnancy.”

#Pregnancy #Paralysis #Guillain #Barre #Neurological #Influenza #Flu #H1N1 #Vaccine #MedScienceResearch

Guillain-Barre syndrome after influenza vaccine administration: two adult cases.

“We describe two adult cases of neurologic complications occurring after the administration of the influenza vaccine. The first case described is a 68 year-old man who experienced paresthesias of the upper and lower extremities two weeks after vaccination, and the second case was a 64 year-old female who exhibited paraplegia eighteen days after vaccination. Diagnosis of acute idiopathic demyelinating polyradiculopathy (Guillain-BarrĂ© syndrome) was made for both patients, and intravenous gammaglobulin therapy was given with marked improvement of the first case, but poor response on the second case. Although the efficacy of influenza vaccination has been widely accepted, such neurologic complications might occur in the elderly and adult population. Even if Guillain-BarrĂ© syndrome was a true side effect of vaccination, the risk is substantially lower than is the risk for complications following influenza. The rare occurrence of neurological complications after influenza vaccine should not discourage against the vaccination.”

#Guillain #Barre #Neurological #Influenza #Flu #Vaccine #MedScienceResearch

Guillain-Barré syndrome after vaccination in United States: data from the Centers for Disease Control and Prevention/Food and Drug Administration Vaccine Adverse Event Reporting System (1990-2005).

“There were 1000 cases (mean age, 47 years) of GBS reported after vaccination in the United States between 1990 and 2005. The onset of GBS was within 6 weeks in 774 cases, >6 weeks in 101, and unknown in 125. Death and disability after the event occurred in 32 (3.2%) and 167 (16.7%) subjects, respectively. The highest number (n = 632) of GBS cases was observed in subjects receiving influenza vaccine followed by hepatitis B vaccine (n = 94). Other vaccines or combinations of vaccines were associated with 274 cases of GBS. The incidence of GBS after influenza vaccination was marginally higher in subjects <65 years compared with those >or=65 years (P = 0.09); for hepatitis vaccine, the incidence was significantly higher (P < 0.0001) in the <65 group. Death was more frequent in subjects >or=65 years compared with those <65 years (P < 0.0001)." #Guillain #Barre #Death #Neurological #Influenza #Hepatitis B #Flu #Vaccine #MedScienceResearch

Guillain-Barré syndrome among recipients of Menactra meningococcal conjugate vaccine-United States, June-July 2005.

“Case Reports

Case 1. A male aged 18 years was vaccinated with MCV4; 15 days later, he experienced tingling in his feet and hands. He had no history of major underlying illness; his mother had had GBS 5 years earlier. He reported no history of respiratory or gastrointestinal illnesses during the 6 weeks before onset of symptoms. Sixteen days after vaccination, he was hospitalized, and nerve conduction studies (NCS) of upper and lower extremities, 2 days after onset of symptoms, were consistent with GBS. He was observed for 3 days, discharged, and then readmitted 2 days later with bilateral facial weakness and increasing lower extremity weakness. Patellar, triceps, and biceps deep tendon reflexes (DTRs) were absent. NCS performed 4 days after the previous examination revealed worsening motor nerve conduction velocities consistent with GBS. Tests for mononucleosis and Lyme disease were negative. During hospitalization, he was treated with plasmapheresis. His facial palsy and gait improved, and his reflexes returned. He was discharged home.

Case 2. A male aged 17 years was vaccinated with MCV4; approximately 25 days later, he had difficulty walking, followed by difficulty moving from a standing to a seated position. Medical history included attention deficit hyperactivity disorder and Asperger syndrome; he had been taking multiple psychotropic medications. He did not report recent respiratory or gastrointestinal illness. Thirty-two days after vaccination, he was hospitalized with bilateral muscle weakness of upper and lower extremities with absent DTRs. NCS was consistent with GBS. Cerebrospinal fluid (CSF) analysis revealed 2 white blood cells (WBC)/mm3 with protein of 60 mg/dL; bacterial cultures were negative. DNA polymerase chain reaction (PCR) for adenovirus, herpes simplex virus types 1 and 2, varicella zoster virus, cytomegalovirus (CMV), and Epstein-Barr virus (EBV), and RNA PCR for West Nile virus, eastern equine encephalitis virus, St. Louis encephalitis virus, enterovirus, and California group and Cache Valley viruses, were all negative. During hospitalization, he was treated with intravenous immunoglobulin (IVIG). On discharge, his motor strength and gait were improved.

Case 3. A female aged 17 years was vaccinated with MCV4. She had a previous history of GBS at ages 2 and 5 years, both beginning 14 days after vaccination with childhood vaccines. She had not been previously vaccinated with meningococcal vaccine. Both episodes of GBS were characterized by muscle weakness, decreased reflexes, and difficulty walking. During both episodes, she was treated with intravenous immunoglobulin and completely recovered. Fourteen days after vaccination with MCV4, she reported numbness of toes and tongue and had a lump in her throat. These symptoms were followed by numbness of thighs and fingertips, arm weakness, inability to run, difficulty walking, and falling. Sixteen days after vaccination, she was hospitalized, and neurologic examination revealed decreased tone and weakness of both arms and legs and reflexes reduced or absent in ankles, knees, and arms. CSF results revealed 0 WBC/mm3 and protein 26 mg/dL. She was treated with IVIG, recovered, and discharged home.

Case 4. A female aged 18 years was vaccinated with MCV4. Six days after vaccination, she had a sore throat that lasted for 6 days, and 29 days after vaccination she reported a severe headache and was evaluated in an emergency department (ED), where she had a normal computerized tomography (CT) scan, was treated with ketorolac, and discharged on oral ibuprofen. Thirty-one days after vaccination, the patient reported numbness of legs and had trouble standing on her toes. The next morning she could not stand. The patient was admitted to the hospital, and physical examination revealed decreased muscle strength in ankles and wrists bilaterally and reduced biceps, knee, and ankle DTRs. Previous medical history included mild ulcerative colitis that had been asymptomatic off medications; she did not report having diarrhea during the 6 weeks before onset of muscle weakness. Her only outpatient medications were oral contraceptives. CSF analysis revealed 1 WBC/mm3 and a protein concentration of 30 mg/dL. NCS was consistent with GBS. She was treated with IVIG. After a 7-day hospitalization, her motor strength had improved, and she was discharged home with outpatient physical therapy. Three weeks after discharge, her weakness and gait were improved.

Case 5. A female aged 18 years was vaccinated with MCV4; 14 days later, she experienced heaviness in her legs when walking upstairs. During the next 8 days, her difficulty walking continued, and she had bilateral leg pain. Subsequently, she reported headache, back and neck pain, vomiting, and tingling in both hands. She became unable to walk and was evaluated in an ED, where an initial diagnosis of viral meningitis was made. Two days later, she was hospitalized for progressive weakness and inability to walk. Neurologic examination revealed bilateral acute flaccid weakness with decreased DTRs.”

#Gullain #Barre #Neurological #Vaccine #Meningococcal #MedScienceResearch

Guillain - Barre’ syndrome following recombinant hepatitis B vaccine and literature review.

“A 17 year-old woman developed progressive quadriparesis with bilateral facial diplegia after immunization with recombinant hepatitis B vaccine 3 days prior. Cerebrospinal fluid analysis revealed acellular fluid with high protein level. The electrodiagnosis was compatible with demyelinating polyneuropathy. Other potential causes of Guillain-Barre’ syndrome (GBS) were ruled out. Her motor power gradually improved and returned to normal later. The temporal relationship between GBS and vaccination was suggestive of a vaccine-induced cause. Mechanisms of this very rare complication are proposed with a literature review.”

#Paralysis #Vaccine #Neurological #Hepatitis B #Guillain #Barre #MedScienceResearch

Guillain-Barre syndrome occurring after rabies vaccination.

“A variety of events are associated with the onset of Guillain-Barre syndrome, including vaccinations and vaccines. These are the swine influenza vaccine, oral poliovirus vaccine and rabies vaccine. Rabies is a uniformly fatal disease. It is preventable if World Health Organization (WHO) guidelines for post exposure treatment (PET) are followed. These include local treatment of wound, passive immunization with rabies immunoglobulins and administration of a efficacious vaccine. Cell culture vaccines are highly immunogenic with fewer side effects, but are costly. For that reason neurotissue vaccines are still widely used in Pakistan, although they are less immunogenic with higher incidence of neuroparalytic complications. We report a case of Guillain-Barre syndrome secondary to sheep brain anti-rabies vaccine in a young boy, who presented with lower limb weakness with total recovery after treatment.”

#Guillain #Barre #Rabies #Neurological #Influenza #Flu #Polio #Vaccine #MedScienceResearch

Gulf war syndrome: could it be triggered by biological warfare-vaccines using pertussis as an adjuvant?

“Several recent epidemiological studies have shown that vaccinations against biological warfare using pertussis as an adjuvant were associated with the Gulf war syndrome. If such epidemiological findings are confirmed, we propose that the use of pertussis as an adjuvant could trigger neurodegeneration through induction of interleukin-1beta secretion in the brain. In turn, neuronal lesions may be sustained by stress or neurotoxic chemical combinations. Particular susceptibility for IL-1beta secretion and potential distant neuronal damage could provide an explanation for the diversity of the symptoms observed on veterans.”

#Gulf #War #Syndrome #Vaccine #Neurological #Pertussis #MedScienceResearch

🛑 Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

“After reviewing the literature, we observed that complications seen after Hepatitis B vaccination are sudden infant death syndrome, multiple sclerosis, chronic fatigue syndrome, idiopathic thrombocytopenic purpura, vasculititis optic neuritis, anaphylaxis, systemic lupus erytymatosus, lichen planus and neuro-muscular disorder.”

#Sudden #Infant #Death #Syndrome #SIDS #Hepatitis B #Multiple #Sclerosis #Neurological #Chronic #Fatigue #Syndrome #Lupus #Dermatological #Anaphylaxis #Ophthalmological #Thrombocytopenia
#Vaccine #MedScienceResearch

High diversity of poliovirus strains isolated from the central nervous system from patients with vaccine-associated paralytic poliomyelitis.

#Polio #Neurological
#Vaccine #Failure

Hypothesis: Human papillomavirus vaccination syndrome-small fiber neuropathy and dysautonomia could be its underlying pathogenesis.

#HPV #Gardasil #CRPS #Vaccine
#POTS #Fibromyalgia #Small #Fiber #Neuropathy #Neurological #MedScienceResearch

Idiopathic Parkinson’s disease(s) may follow subclinical episodes of perivenous demyelination.

“Three case studies of postvaccinal parkinsonism (PVP) demonstrated signs and symptoms identical to conventional diagnostic standards of idiopathic Parkinson’s disease (PD). PVP is a sub-type of acute disseminated encephalomyelitis (ADE) that also includes postinfectious parkinsonism (PIP) and postinfectious encephalomyelitis (PIE).”

#Parkinsons #Vaccine #ADEM #Neurological #Encephalomyelitis #MedScienceResearch

🛑 Imported Vaccine-Associated Paralytic Poliomyelitis — United States, 2005

“This report describes the first known occurrence of imported VAPP in an unvaccinated U.S. adult who traveled abroad, where she likely was exposed through contact with an infant recently vaccinated with OPV.”

“Upon admission to a hospital in Phoenix, the patient had bilateral areflexic lower extremity weakness and respiratory failure requiring intubation.”

“The host family’s son and daughter-in-law lived next door with two children, aged 2 months and 3 years, who visited the host family frequently. The infant received his first dose of OPV on January 19, 2005, 4 days after the woman arrived to live with the host family.”

#Recently #Vaccinated #Shedding
#Polio #Paralysis
#Neurological #Respiratory
#Vaccine #MedScienceResearch

🛑 Infant meningoencephalitis caused by yellow fever vaccine virus transmitted via breastmilk.

“In 2009, the first case was confirmed of meningoencephalitis caused by the yellow fever vaccine virus transmitted via breastmilk. We describe a second case in which the vaccine virus was possibly the etiologic agent of meningoencephalitis.”

#Breastfeeding #Seizures #Shedding #Neurological
#Yellow #Fever #Vaccine #MedScienceResearch

Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study.

“These results suggest that maturational changes in amygdala volume and the binding capacity of [(11)C]DPN in the amygdala was significantly altered in infant macaques receiving the vaccine schedule.”

#Neurological #Vaccines

Influenza vaccine-induced CNS demyelination in a 50-year-old male.

#ADEM #Neurological #Influenza #Flu #Vaccine #MedScienceResearch

Intrafamilial transmission of a Sabin 1-related poliovirus in Shizuoka Prefecture, Japan.

#Recently #Vaccinated #Shedding #Polio #Neurological #Vaccine

Ischaemic stroke and influenza A H1N1 vaccination: a case report.

“We report a 75-year-old male patient who suffered posterior circulation ischaemia after influenza A/H1N1 vaccination. Vaccination provokes a variable magnitude of inflammatory and immunological response that modifies the risk for ischaemic stroke. Whereas a causal relation between vaccination and ischaemic stroke is still unsettled, an inflammatory/immunological response after vaccination may trigger thrombosis superimposing a pre-existing prothrombotic state. Careful monitoring is strongly suggested for individuals who received H1N1 vaccine, especially those with high ischaemic stroke risk.”

#Stroke #Influenza #Flu #H1N1 #Neurological #Vaccine #MedScienceResearch

Lumbosacral acute demyelinating polyneuropathy following hepatitis B vaccination.

“We report a patient who presented with an acute inflammatory demyelinating polyneuropathy, that followed the second injection of a hepatitis B vaccination, and characterized by motor and sensory deficit restricted to lower limbs and perineum, and persistent bladder dysfunction. The relationship between the preceding event and neurological disease is discussed.”

#Neurological #Hepatitis B #Bladder #Vaccine #MedScienceResearch

Major Birth Defects after Vaccination Reported to the Vaccine Adverse Event Reporting System (VAERS), 1990 to 2014.

“We identified 50 reports of major birth defects; in 28 reports, the vaccine was given during the first trimester; 25 were reports with single vaccines administered.”

#Pregnancy #Birth #Defects #VAERS #Musculoskeletal #Neurological #Vaccine #MedScienceResearch

Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures.

#Seizures #MMRV #MMR #Neurological #Vaccine #MedScienceResearch

Mechanism of Injury-Provoked Poliomyelitis

#Polio #Failure #Paralysis #Vaccine #Neurological #MedScienceResearch

Mental nerve neuropathy as a result of hepatitis B vaccination.

#Neurological #Hepatitis B #Vaccine #MedScienceResearch

MRI findings in an infant with vaccine-associated paralytic poliomyelitis.

“We report a Brazilian infant who developed VAPP 40 days after receiving the first dose of oral polio vaccine (OPV). MR images of the cervical and thoracic spinal cord showed lesions involving the anterior horn cell, with increased signal intensity on T2-weighted sequences. We would like to emphasize the importance of considering VAPP as a differential diagnosis in patients with acute flaccid paralysis and an MRI showing involvement of medulla oblongata or spinal cord, particularly in countries where OPV is extensively administered.”

#Polio #Vaccine #Failure #Paralysis #Neurological #MedScienceResearch

The muscle findings in a pediatric patient with live attenuated oral polio vaccine-related flaccid monoplegia.

#Polio #Vaccine #Paralysis #Neurological #MedScienceResearch

[Neurologic complications due to a sample type of rabies vaccination].

#Rabies #Neurological #Paralysis #Vaccine #MedScienceResearch

[Neurologic Complications in HPV Vaccination].

#HPV #Gardasil #POTS #Neurological #CRPS #Vaccine #MedScienceResearch

Neurologic complications in oral polio vaccine recipients.

“A vaccine-like strain of poliovirus was isolated from each patient, and each had symptoms (left leg paralysis in three; developmental regression, spasticity, and progressive fatal cerebral atrophy in one) persisting for at least 6 months.”

#Polio #Neurological #Neurodevelopmental #Paralysis #Vaccine #Failure #MedScienceResearch

Neurologic illness following post-exposure prophylaxis with purifiled chick embryo cell antirabies vaccine.

#Rabies #Neurological #Vaccine #MedScienceResearch

[Neurologic manifestations following pertussis vaccination].

“Twenty cases of acute neurological complications occuring within 7 days of pertussis immunization are reported. Convulsions were present in every case and status epilepticus was observed in five infants. In only 4 cases were neurological or epileptic sequelae lacking. The clustering of neurological complications in the 24 hours following immunization is not consistent with the hypothesis of a mere temporal coincidence. However, the mechanism and incidence of post-immunization encephalopathies remains obscure and epidemiological studies are in order.”

#Seizures #Encephalopathy #Neurological #Pertussis #Vaccine

Neurologic tumors in offspring after inoculation of mothers with killed-poliovirus vaccine.

No abstract available

PMID 2845271 [PubMed - indexed for MEDLINE]

#Tumors #Polio #Neurological #Vaccine #MedScienceResearch

Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden.

“Relative risks were significantly increased for Bell’s palsy, paraesthesia, and inflammatory bowel disease after vaccination, predominantly in the early phase of the vaccination campaign.”

#Neurological #Autoimmunity #Gastrointestinal #Bells #Palsy #H1N1 #Influenza #Flu #Vaccine #MedScienceResearch

🛑 Neuroparalytic accidents of antirabies vaccination with suckling mouse brain vaccine. Clinical and pathologic study of 21 cases. 

“Twenty-one cases of neuroparalytic accidents of rabies vaccination (with suckling mouse brain vaccine), 11 of them fatal, were observed, occurring predominantly in men; the mean age of the patients was 29 years.”

#Death #Paralysis #Neurological #Vaccine #Rabies #MedScienceResearch

Neuropathology of vaccination in infants and children.

“AIMS: Documentation of clinical-pathological features of 37 infants/children whose parents alleged a relationship between vaccination and death or permanent central nervous system (CNS) damage, and sought compensation through the National Vaccine Injury Compensation Program.

SCOPE: Of the 5545 claims filed during the 10-year period (1990-1999), CNS tissue was available for evaluation by a pediatric neuropathologist in 37; 33 died and 4 had a biopsy or lobectomy. Most commonly implicated vaccines were DTP/DTaP, followed by MMR and IPV/OPV, but almost all of the vaccines currently given to infants/children were alleged to be responsible for the illness/death. No lesions were found in 5 of 37 (13.5%). The most frequent abnormality consisted of acute anoxic encephalopathy (14 of 37 - 37.8%), consequent to several different causes, such as positional asphyxia, cardio-respiratory arrest during status epilepticus, etc. The remaining children manifested other lesions, including inflammation (5 of 37 - 13.5%), vascular and developmental anomalies (4 each of 37 or 10.6%), cerebral edema and system degeneration (2 each of 37 or 5.4%), and one case of heavy metal exposure in a child living near an abandoned mine (2.2%).”

#Death #Neurological
#Polio #DTaP #MMR #DTP #Vaccine #VAERS #MedScienceResearch

The neurotoxicity of environmental aluminum is still an issue

If you think eating aluminum is bad, just think what happens when it’s injected and bypasses the normal protective biological barriers.

#Parkinsons #Alzheimers
#Aluminum #Vaccine #MedScienceResearch

Nonfebrile seizures after mumps, measles, rubella, and varicella-zoster virus combination vaccination with detection of measles virus RNA in serum, throat, and urine.

“We report the case of a child presenting with nonfebrile seizures 6 and 13 days after the first vaccination with a measles, mumps, rubella, and varicella (MMRV) combination vaccine. Measles virus RNA was detected in the patient’s serum, throat, and urine. Genotyping revealed the Schwarz vaccine virus strain.”

#Shedding #Measles #MMRV #Seizures #Neurological
#Vaccine #MedScienceResearch

A novel vaccinological evaluation of intranasal vaccine and adjuvant safety for preclinical tests.

“However, the addition of adjuvants to vaccines may cause unwanted immune responses, including facial nerve paralysis and narcolepsy. ”

#Narcolepsy #Paralysis
#Neurological #Vaccine #MedScienceResearch

Opsoclonus Myoclonus after human papilloma virus vaccine in a pediatric patient.

“Opsoclonus-Myoclonus Syndrome (OMS) is a rare neurologic condition comprised of the two hallmark signs of dysmetric ocular ataxia and myoclonic jerks of the extremities. The eye movements have been described as “dancing eyesâ€?. The eyes dart involuntarily away from the point of visual fixation or pursuit in a manner that can be considered a myoclonic jerk of the extra-ocular muscles. When the patient attempts to align the gaze on a point, there may be dysmetric overshoot of the eye movement. Myoclonic movements of the extremities occur at rest, and intended actions are ataxic. The mean age of presentation of OMS in childhood is 14 months, and it presents as a paraneoplastic syndrome associated with an underlying tumor in 50–60% of the cases [1,2], most commonly neuroblastoma or ganglioneuroblastoma. Recent research has revealed the presence of several auto-antibodies including anti-Hu, anti-Ri, α-Enolase, KSRP and NLK [3] in patients with OMS. These antibodies bind to an array of targets in the cerebellum and may manifest as oligoclonal bands in cerebrospinal fluid. The syndrome is often associated with behavioral changes such as aggression, irritability, and insomnia. Post-vaccine OMS is not well described in the pediatric population. The patient was a fully vaccinated and developmentally appropriate 11-year-old female with seasonal allergies and mild asthma. Her initial symptoms consisted of a sudden onset of increased “moodinessâ€? causing uncharacteristic anger and depression. These symptoms presented approximately 15 days after receiving her first human papilloma virus (HPV) (Gardisil®) vaccination on 11/26/2007. The uncharacteristic behavior persisted and 1 month after the initial mood changes she noted that her “eyes were doing weird thingsâ€? and she perceived that visual images went “back and forth in circlesâ€?. The abnormal ocular movements occurred with her eyes closed or open, and could be only minimally suppressed with great effort. There were no other symptoms at this time, however, her eye symptoms became more frequent and troubling to her. She then received a second HPV vaccination 2 months later in addition to a meningococcal (Menactra®) vaccine. Four days after these vaccinations she developed noticeable worsening of the eye movements and acute perception of dizziness, which she described as the “room is spinning.â€? This was accompanied by leg weakness requiring assistance to walk and “jumpy arms.â€? Family history reveals a cousin with childhood epilepsy, maternal great aunt with lupus, maternal grandfather died of a ruptured aneurysm at age 40, and mother with fibromyalgia, but no movement disorders or paraneoplastic syndromes. There is one case report of post-vaccine OMS in a 30-year-old female with an allergic diathesis [4]. Her symptoms began two weeks after a vaccine. She failed to improve with corticosteroid therapy, but IVIG was not used. She derived clinical benefit from benzodiazepines and her symptoms resolved completely within 10 months.”

#Gardasil #Neurological #HPV
#Ophthalmological #Eyes #Ataxia #Psychiatric #Meningococcal
#Vaccine #MedScienceResearch

Partial third nerve palsy after MMR.

#Strabismus #Eyes #MMR #Ophthalmological
#Neurological #Vaccine #MedScienceResearch

Peripheral sympathetic nerve dysfunction in adolescent Japanese girls following immunization with the human papillomavirus vaccine.

#Gardasil #Neurological #CRPS #POTS #Vaccine #HPV

🛑 A possible central mechanism in autism spectrum disorders, part 1.

“The autism spectrum disorders (ASD) are a group of related neurodevelopmental disorders that have been increasing in incidence since the 1980s. Despite a considerable amount of data being collected from cases, a central mechanism has not been offered. A careful review of ASD cases discloses a number of events that adhere to an immunoexcitotoxic mechanism. This mechanism explains the link between excessive vaccination, use of aluminum and ethylmercury as vaccine adjuvants, food allergies, gut dysbiosis, and abnormal formation of the developing brain. It has now been shown that chronic microglial activation is present in autistic brains from age 5 years to age 44 years. A considerable amount of evidence, both experimental and clinical, indicates that repeated microglial activation can initiate priming of the microglia and that subsequent stimulation can produce an exaggerated microglial response that can be prolonged. It is also known that one phenotypic form of microglia activation can result in an outpouring of neurotoxic levels of the excitotoxins, glutamate and quinolinic acid. Studies have shown that careful control of brain glutamate levels is essential to brain pathway development and that excesses can result in arrest of neural migration, as well as dendritic and synaptic loss. It has also been shown that certain cytokines, such as TNF-alpha, can, via its receptor, interact with glutamate receptors to enhance the neurotoxic reaction. To describe this interaction I have coined the term immunoexcitotoxicity, which is described in this article.”

#Autism #Immune #Aluminum
#Mercury #Food #Allergies
#Neurological #Vaccine #MedScienceResearch

Postpartum rubella immunization: association with development of prolonged arthritis, neurological sequelae, and chronic rubella viremia.

#Shedding #Breastfeeding #Arthritis #Rubella #Neurological
#Vaccine #MedScienceResearch

[Postvaccinal complication and medical malpractice law].

“The case report involves a 38-year-old female patient with muscular atrophy, paresis and sensory deficits in the right upper limb following several vaccinations. A legal dispute ensued over whether medical malpractice could have caused the neurological deficits. Medical malpractice could not be confirmed. Even vaccinations administered correctly can lead to neurological impairment.”

#Neurological #Vaccine #MedScienceResearch

Post-vaccination encephalomyelitis: literature review and illustrative case.

#ADEM  #Neurological
#Rabies #Tetanus #Polio #Smallpox #MMR #DTP #Influenza #Hepatitis B #Vaccine #MedScienceResearch

Postnatal toxic and acquired disorders.

#Aluminum #Neurological #MedScienceResearch

Postvaccinal parkinsonism.

#Parkinsonism #Neurological
#Measles #Vaccine

Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration.

“Epidemiological studies suggest that aluminum may not be as innocuous as was previously thought and that aluminum may actively promote the onset and progression of Alzheimer’s disease.”

#Aluminum #Alzheimers
#Neurological #MedScienceResearch

[Recurrent encephalitis following annual influenza vaccine. Case report].

“Influenza vaccine is rarely associated with neurological adverse effects such as Guillain BarrĂ© syndrome, encephalitis or aseptic meningitis. We report the case of a male patient that presented two episodes of acute encephalitis in consecutive years, 16 and 20 days after his annual influenza vaccine shot, respectively. In both instances, patient required ICU admission and evolved with fast recovery and no sequels. The first episode was managed empirically as herpetic encephalitis but an extensive study was performed in the second episode without identifying any microorganism. Neuroimaging studies also discarded acute disseminated encephalomyelitis. Mild pleocytosis of mononuclear predominance was detected in both cases in CSF. Naranjo score punctuated 8 points indicating a probable causal relationship. Acute encephalitis is a rare adverse effect of influenza vaccine and occurs several days after immunization. It has a broad differential diagnosis, and appears to be of self-limited duration and associated with good prognosis.”

#Encephalitis #Flu #Influenza #Vaccine #Neurological #MedScienceResearch

Recurrent Guillain-Barré syndrome following influenza vaccine.

“Two patients recovered from an attack of Guillain-BarrĂ© syndrome and then had a second attack of this disease, with a shorter latent period, following monovalent influenza vaccination. These cases suggest that an attack of Guillain-BarrĂ© syndrome may result in greater risk of future episodes of the syndrome in conjunction with exposure to influenza or other vaccinations.”

#Guillain #Barre #Neurological
#Influenza #Flu #Vaccine #MedScienceResearch

Recurrent isolated sixth nerve palsy after consecutive annual influenza vaccinations in a child.

#Ophthalmological #Eyes #Influenza #Flu #Neurological #Vaccine #MedScienceResearch

Recurrent optic neuritis and neuromyelitis optica-IgG following first and second human papillomavirus vaccinations.

“We report a case of neuromyelitis optica spectrum disorder (NMOSD) that was noteworthy because optic neuritis (ON) occurred in a very close temporal association with both the first and second HPV vaccinations, which might suggest an association between HPV vaccination and the development of NMO-IgG and recurrent ON.”

#Gardasil #HPV #Neurological
#Ophthalmological #Eyes #Vaccine #MedScienceResearch

Recurrent seizures after diphtheria, tetanus, and pertussis vaccine immunization. Onset less than 24 hours after vaccination.

“Twenty-two patients with recurrent seizures that started less than 24 hours after immunization with diphtheria, tetanus, and pertussis (DTP) vaccine were retrospectively studied. The initial seizure generally occurred after one of the first three DTP vaccine immunizations, and followed that immunization by less than 12 hours. Two of the 22 patients were siblings. Eight patients had additional immunizations with DTP vaccine and four had immediate worsening of their seizures. Of the 22 patients, only one was seizure free and stopped taking anticonvulsants. Three patients exhibited normal development, and 11 had severe developmental delays. Based on these observations, we reviewed current contraindications for immunization with pertussis vaccine.”

#Seizures #DTP #Neurological #Vaccine #MedScienceResearch

Rett syndrome phenotype following infantile acute encephalopathy.

“We report on a girl who, at age 2 months, developed an acute encephalopathy with destructive brain damage 12 hours after acellular pertussis vaccination.”

#DTaP #Vaccine #Encephalopathy #Neurological #Rett

Reversible posterior leukoencephalopathy and Adie’s pupil after measles vaccination.

“Reversible posterior leukoencephalopathy syndrome is an increasingly recognized disorder with typical radiologic findings of bilateral gray- and white-matter abnormalities in the posterior regions of the cerebral hemispheres. The majority of patients with reversible posterior leukoencephalopathy syndrome are adults, and it is rare in children. Previously reported associations of reversible posterior leukoencephalopathy syndrome include hypertension, vasculitis, nephrotic syndrome, severe hypercalcemia, hemolytic uremic syndrome, eclampsia, renal failure, and use of immunosuppressive drugs. Adie’s pupil is described as the presence of a large unilateral or bilateral tonic pupil related to virus infections or trauma. In this article, we describe a case of reversible posterior leukoencephalopathy and Adie’s pupil association that occurred after measles vaccination. To our knowledge, this association has not been reported.”

#Measles #Vaccine #Neurological

Safety of Quadrivalent Meningococcal Conjugate Vaccine in 11- to 21-Year-Olds.

#Bells #Palsy #Meningococcal #Neurological #Vaccine #MedScienceResearch

Semple rabies vaccine: presence of myelin basic protein and proteolipid protein and its activity in experimental allergic encephalomyelitis.

#Rabies #Vaccine #Neurological #Encephalomyelitis #Allergy #MedScienceResearch

Seronegative Neuromyelitis Optica Spectrum Disorder following Exposure to Hepatitis B

#Ophthalmological #Neurological #Eyes #Hepatitis B #Vaccine #MedScienceResearch

Severe but transient parkinsonism after tetanus vaccination.

#Parkinsonism #Tetanus #Vaccine #Neurological #MedScienceResearch

Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature.

#HPV #Gardasil #Cervarix #Dysautonomia #ASIA #Autoimmunity
#Neurological #Vaccine #MedScienceResearch

🛑 [Should yellow fever vaccination be recommended during pregnancy or breastfeeding?]. 2010.

“Regarding breastfeeding, the risk was recently confirmed by a report describing vaccine-induced encephalitis occurring in an infant 8 days after primary vaccination of the mother.”

#Breastfeeding #Shedding #Encephalitis #Neurological
#Yellow #Fever #Vaccine

Simultaneous development of acute disseminated encephalomyelitis and Guillain-Barré syndrome associated with H1N1 09 influenza vaccination.

“A 36-year-old man was admitted to our hospital because of urinary retention and muscle weakness affecting all 4 limbs after receiving a H1N1 09 influenza vaccination. Magnetic resonance imaging demonstrated multiple lesions in his brain and spinal cord. Furthermore, nerve conduction study showed acute sensorimotor neuropathy, and anti-GM2 antibodies were detected in his serum. Based on the temporal association and exclusion of alternative etiologies, we made a diagnosis of acute disseminated encephalomyelitis (ADEM) and Guillain-BarrĂ© syndrome (GBS). To our knowledge, this is the first case of co-morbid ADEM and GBS after influenza vaccination with positive anti-ganglioside antibodies.”

#Neurological #ADEM #Encephalomyelitis
#Guillain #Barre
#H1N1 #Influenza #Flu
#Vaccine #MedScienceResearch

Small fiber neuropathy following vaccination for rabies, varicella or Lyme disease

#Small #Fiber #Neuropathy #Rabies #Lyme #Neurological
#MedScienceResearch #Varicella #Chickenpox #Vaccine

Small Fiber Neuropathy Following Vaccination.

#Small #Fiber #Neuropathy
#HPV #Neurological #Vaccine #MedScienceResearch

Smallpox and smallpox vaccination: neurological implications.

#Neurological #Smallpox #Immune
#Vaccine #MedScienceResearch

State of the art: Could nursing mothers be vaccinated with attenuated live virus vaccine?

“Recently two cases of vaccine-associated neurologic disease have been reported in breastfed infants whose mothers had received live attenuated yellow fever vaccine.”

#Breastfeeding #Shedding #Neurological #Yellow #Fever #Vaccine #MedScienceResearch

Status epilepticus and lymphocytic pneumonitis following hepatitis B vaccination.

“The case reported refers to a patient who developed status epilepticus in the day of her third dose of hepatitis B vaccination and we review the literature on this subject. A 12 year-old girl, without a relevant previous history, taking no drugs, developed a seizure attack followed by unconsciousness, and eventually died after three days of her third dose of hepatitis B (HB) vaccination. Autopsy study revealed cerebral edema with congestion and herniation and diffuse interstitial type pneumonitis. There seem to be a straight forward time relationship between the third HB vaccine, the event of convulsion and the sudden death of the patient. We suggest that, in some cases, vaccination may be the triggering factor for autoimmune and neurological disturbances in genetically predisposed individuals and physicians should be aware of this possible association.”

#Death #Neurological #Seizures #Autoimmunity #Hepatitis B #Vaccine #MedScienceResearch

Stroke after varicella vaccination.

“Two children presented with acute hemiparesis 5 days and 3 weeks following varicella vaccination. Both showed unilateral infarction of the basal ganglia and internal capsule, a distribution consistent with varicella angiopathy.”

#Stroke #Varicella #Chickenpox #Neurological #Vaccine #MedScienceResearch

Syncope and seizures following human papillomavirus vaccination: a retrospective case series.

#Gardasil #Syncope #Seizures
#HPV #Neurological #Vaccine #MedScienceResearch

Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case-Control Study.

#Anxiety #ADHD #Attention #Deficit #Disorder #Tics #OCD #Anorexia
#Obsessive Compulsive Disorder
#Psychiatric #Meningitis #Hepatitis A
#Hepatitis B #Autoimmunity #Influenza #Flu #Neurological

Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria.

“There is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative. In this study, we show that thimerosal, at nanomolar concentrations, induces neuronal cell death through the mitochondrial pathway. Thimerosal, in a concentration- and time-dependent manner, decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye. Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane, generation of reactive oxygen species, and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol. Although thimerosal did not affect cellular expression of Bax at the protein level, we observed translocation of Bax from cytosol to mitochondria. Finally, caspase-9 and caspase-3 were activated in the absence of caspase-8 activation. Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironment.”

#Thimerosal #Neurological #Mitochondria #Mercury
#Apoptosis #Vaccine #MedScienceResearch

Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal.

#Autism #Neurological #Vaccine  #Endocrine #Thimerosal #MedScienceResearch

Transient facial nerve paralysis (Bell’s palsy) following administration of hepatitis B recombinant vaccine: a case report.

#Bells #Palsy #Hepatitis B #Neurological #Vaccine #MedScienceResearch

Transverse myelitis and vaccines: a multi-analysis.

“We have disclosed 37 reported cases of transverse myelitis associated with different vaccines including those against hepatitis B virus, measles-mumps-rubella, diphtheria-tetanus-pertussis and others, given to infants, children and adults.”

#Transverse #Myelitis #Autoimmunity  #Neurological #Immune #Hepatitis B #MMR #DTP #Vaccine #MedScienceResearch

Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus.

“We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.”

#Gardasil #Encephalomyelitis #ADEM #HPV #Neurological #Vaccine #MedScienceResearch

Unusual features of the Guillain-Barré syndrome after rabies vaccine prepared in suckling mouse brain.

“Five patients with acute polyneuritis following treatment with rabies vaccine prepared in suckling mouse brains are reported. These patients had severe and protracted disease. The extensive cranial nerve involvement, high mortality rate, and disabling longterm sequelae were in contrast to cases of the Guillain-BarrĂ© syndrome not associated with the vaccine.”

#Neurological #Rabies #Vaccine
#Death #MedScienceResearch

Vaccination to Alzheimer Disease. Is it a Promising Tool or a Blind Way?

“Unfortunately, the promising vaccines like the AN 1792 were halted during clinical trials because of adverse effects like meningoencephalitis.”

#Vaccine #Failure #Alzheimers #Neurological #MedScienceResearch

Vaccine-associated contact paralytic poliomyelitis with atypical neurological presentation.

“Paralytic poliomyelitis presenting with quadriparesis, transient encephalitis and bulbar symptoms in 2 patients in close contact with recently vaccinated children with trivalent live oral polio vaccine is described. Symmetrical lower motor neuron involvement of deltoid muscles with electromyographic confirmation was found. Upper motor neuron signs, with symmetrical hyperactive deep tendon reflexes developed in the lower extremities. Poliovirus Type-2 vaccine-like strain was cultured from one patient and both patients showed significant antibody titers rises to poliovirus. Attention is drawn to the possible clinical differences between vaccine associated poliomelitis and the usual features found in wild strain poliomyelitis. It is suggested that in selected cases, non-immunized contacts be given inactivated polio-vaccine when the vaccinees are immunized with the live oral-vaccine.”

#Shedding #Recently #Vaccinated #Paralysis #Polio #Encephalitis
#Neurological #Vaccine #MedScienceResearch

🛑 Vaccine-associated paralytic poliomyelitis: a case report of domiciliary transmission.

“We herein present the case of an unvaccinated child, with a clinical picture of an acute anterior poliomyelitis associated with the live strain vaccine, whose brother received the Sabin vaccine 20 days before the onset of the symptoms. Vaccine strain of the type 3 poliovirus was isolated in fecal culture and a presented mutation in nucleotide 472 (C->U) in the 5′ non-coding region, which is strongly related to the higher strain virulence.”

#Shedding #Polio #Paralysis
#Recently #Vaccinated
#Neurological #Unvaccinated
#Vaccine #MedScienceResearch

Vaccine-associated paralytic poliomyelitis caused by contact infection.

“We encountered an adult patient with acute anterior poliomyelitis (AAP), whose monoparesis developed 28 days after his son’s immunization with oral poliovirus vaccine (OPV). Neurological and electrophysiological examinations suggested that his muscular wasting of the left lower limb was due to a lower motor neuron disorder, and magnetic resonance imaging revealed the responsible lesion in the left anterior horn at the thoracolumbar junction. His stool was found to include poliovirus type 3, mainly originating from Sabin 3 by neutrization antibody and PCR-restriction fragment length polymorphism method. This indicated that the AAP resulted from contact with his son.”

#Shedding #Polio #Paralysis
#Recently #Vaccinated
#Neurological #Vaccine #MedScienceResearch

Vaccine-related adverse events in Cuban children, 1999-2008.

#Death #DTP #Seizures #Encephalopathy #Polio #Neurological #Vaccine #MedScienceResearch

“The DTwP vaccine exhibited the highest rate of adverse events. Common minor events were: fever (17,538), reactions at injection site (4470) and systemic side effects (2422). Rare events (by WHO definition) reported were: persistent crying (2666), hypotonic-hyporesponsive episodes (3), encephalopathy (2) and febrile seizures (112). Severe events included: anaphylaxis (2), respiratory distress (1), multiple organ failure (1), sudden death (1), vaccine-associated paralytic poliomyelitis (2), toxic shock syndrome (3), and sepsis (1). The 10 deaths and 3 cases of disability were investigated by an expert commission, which concluded that 8 of the 13 severe events were vaccination-related.”

Vaccinia virus in postvaccinal encephalitis.

“Results of virological examination of 239 samples taken from 84 children with neurological complications after smallpox vaccination are described. In postvaccinal encephalitis, vaccinia virus was isolated from blood, cerebrospinal fluid and pharyngeal secretions of 23 out of 40 children (57.5%) as well as from autopsy specimens sampled between 10-35 days after vaccination. During the acute period of disease, virus was detected in 17 out of 31 (54.2%) cerebrospinal fluid specimens. In 3 postvaccinal encephalitis cases the virus was present in brain and in a case of encephalomyelitis-in the spinal cord. These results confirmed the participation of vaccinia virus in the pathogenesis of postvaccinal encephalitis. The pathogenicity of vaccinia virus may be manifested only under a changed reactivity of the vaccinated host.”

#Death #Shedding #Encephalitis
#Neurological #Smallpox
#Vaccine #MedScienceResearch

Mar, 06, 2017