Vaccine failure and vaccine-induced infection:

Note: Also see the category shedding

Acute flaccid paralysis surveillance indicators in the Democratic Republic of Congo during 2008-2014.

“Of the 13,749 AFP cases investigated, 58.9% received at least three doses of oral polio vaccine (OPV), 7.3% never received OPV, while the status of 18.3% was unknown.”

#Polio #Paralysis #Neurological
#Vaccine #Failure #MedScienceResearch

🛑 Adverse events associated with childhood vaccines other than pertussis and rubella. Summary of a report from the Institute of Medicine.

The committee found that the evidence favored acceptance of a causal relation between diphtheria and tetanus toxoids and Guillain-Barré syndrome and brachial neuritis, between measles vaccine and anaphylaxis, between oral polio vaccine and Guillain-Barré syndrome, and between unconjugated Hib vaccine and susceptibility to Hib disease. The committee found that the evidence established causality between diphtheria and tetanus toxoids and anaphylaxis, between measles vaccine and death from measles vaccine-strain viral infection, between measles-mumps-rubella vaccine and thrombocytopenia and anaphylaxis, between oral polio vaccine and poliomyelitis and death from polio vaccine-strain viral infection, and between hepatitis B vaccine and anaphylaxis.

#Death #Guillain #Barre #Polio #Anaphylaxis #Hib #Failure #Tetanus #MMR #Measles #Poliomyelitis #Hepatitis B #Thrombocytopenia
#Vaccine #MedScienceResearch

‘An American tragedy’. the Cutter incident and its implications for the Salk polio vaccine in New Zealand 1955-1960.

“During the United States polio immunisation campaign in 1955 a number of children immunised with Cutter Laboratories vaccine were stricken with the disease, halting the programme.”

#Cutter #Polio #Vaccine #Failure #MedScienceResearch

Aseptic meningitis after vaccination against measles and mumps.

#Meningitis #Mumps #Vaccine #Failure #MedScienceResearch

Bordetella parapertussis outbreak in Southeastern Minnesota and the United States, 2014. (2017)

“All patients were vaccinated against pertussis, suggesting that pertussis vaccination is ineffective against B. parapertussis.”

#Pertussis #Vaccine #Failure

Canine rabies in Nigeria, 1970 - 1980 reported cases in vaccinated dogs.

“Of the 14 cases there were 10 cases of apparent vaccine failure involving modified live (low egg passage chick embryo) vaccine in use during the study period. In 4 of these cases, infection may actually have been induced by the vaccine.”

#Rabies #Vaccine #Failure #Veterinary #Animal #MedScienceResearch


#Measles #Vaccine #Failure #Shedding #MedScienceResearch

🛑 Challenges in Interpretation of Diagnostic Test Results in a Mumps Outbreak in a Highly Vaccinated Population. 2017

“This is the first published report of an outbreak of mumps in Ontario in which all confirmed cases had been vaccinated against the disease.”

#Vaccine #Failure #Mumps #MMR

Characteristics of poliovirus strains from long-term excretors with primary immunodeficiencies.

“Individuals who are deficient in humoral immunity are particularly at risk from infection with enteroviruses, and poliovirus in particular, where antibodies are the main source of protection from disease. Long-term excretion of vaccine strains of poliovirus has been documented for many years and instances of paralytic poliomyelitis in hypogammaglobulinaemic patients who were subsequently found to have been excreting virus for prolonged periods have been reported in the U.S.A., Germany and Japan. The identification of a healthy immunodeficient patient in the U.K. who has probably been excreting type 2 poliovirus for 15 years will be described, with the characteristics of the virus and the results of attempts at treatment so far. Such individuals pose a significant risk to the eradication programme unless they can be identified and treated.”

#Shedding #Polio #Vaccine #Failure #Paralysis #MedScienceResearch

Chronic progressive poliomyelitis secondary to vaccination of an immunodeficient child.

“We investigated an immunodeficient child in whom chronic progressive poliomyelitis developed after she had received live oral poliovirus vaccine. Poliovirus, Type II, was isolated from throat and stool during life and from several sites within the brain at autopsy.”

#Polio #Vaccine #Failure #Shedding #MedScienceResearch

Comparison of neutralizing antibody titers against outbreak-associated measles genotypes (D4, H1 and B3) in Iran.

“Despite the accessibility of a promising vaccine, outbreaks of the measles virus (MV) take place even in well-vaccinated populations.”

#Measles #Vaccine #Failure #MedScienceResearch

Continuing measles transmission in students despite school-based outbreak control program.

“Forty-six cases occurred among students more than two weeks after control program implementation. All 46 had a school record indicating adequate measles vaccination; 13 had been vaccinated at control program clinics by one jet-injector team (Team A).”

#Measles #Vaccine #Failure

Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis.

“Notwithstanding this, we describe here devastating neurological complications associated with the detection of live-attenuated mumps virus Jeryl Lynn (MuV(JL5)) in the brain of a child who had undergone successful allogeneic transplantation for severe combined immunodeficiency (SCID). This is the first confirmed report of MuV(JL5) associated with chronic encephalitis and highlights the need to exclude immunodeficient individuals from immunisation with live-attenuated vaccines.”

#MMR #Mumps #Vaccine #Failure #Encephalitis #Neurological

Detection of fecal shedding of rotavirus vaccine in infants following their first dose of pentavalent rotavirus vaccine.

#Shedding #Rotavirus #Failure #Gastrointestinal #Vaccine #MedScienceResearch

Disseminated, persistent, and fatal infection due to the vaccine strain of varicella-zoster virus in an adult following stem cell transplantation.

#Death #Vaccine #Failure #Shingles #Varicella #Zoster

Efficacy of a Russian-backbone live attenuated influenza vaccine among children in Senegal: a randomised, double-blind, placebo-controlled trial.

“Symptomatic influenza was laboratory-confirmed in 210 (18%) of 1173 recipients of live attenuated influenza vaccine.”

“INTERPRETATION: Live attenuated influenza vaccine was well tolerated in young children in Senegal, but did not provide protection against influenza.”

#Failure #Flu #Influenza #Vaccine

An emergent poxvirus from humans and cattle in Rio de Janeiro State: Cantagalo virus may derive from Brazilian smallpox vaccine.

“Together, the data suggested that CTGV may have derived from VV-IOC by persisting in an indigenous animal(s), accumulating polymorphisms, and now emerging in cattle and milkers as CTGV. CTGV may represent the first case of long-term persistence of vaccinia in the New World.”

#Shedding #Smallpox
#Vaccine #Failure #Veterinary

🛑 Estimating the extent of vaccine-derived poliovirus infection.

“Eight outbreaks of paralytic polio attributable to circulating vaccine-derived poliovirus (cVDPV) have highlighted the risks associated with oral poliovirus vaccine (OPV) use in areas of low vaccination coverage and poor hygiene.”

“Although only 114 virologically-confirmed paralytic cases were identified in the eight cVDPV outbreaks, it is likely that a minimum of hundreds of thousands, and more likely several million individuals were infected during these events, and that many thousands more have been infected by VDPV lineages within outbreaks which have escaped detection.”

#Shedding #Vaccine #Failure #Polio #Acute #Flaccid #Paralysis #Neurological #MedScienceResearch

Evidence for immunisation failure in vaccinated adult dogs infected with canine parvovirus type 2c.

#Parvo #Vaccine #Failure #Death #Veterinary #Animals #MedScienceResearch

[Explosive occurrence of measles in a vaccinated population (author’s transl)].

Markvart K, et al. Cesk Epidemiol Mikrobiol Imunol. 1977.

No abstract available
PMID 140009

#Measles #Vaccine #Failure #MedScienceResearch

Explosive school-based measles outbreak: intense exposure may have resulted in high risk, even among revaccinees.

“Even high levels of measles vaccination coverage have not always prevented outbreaks of measles spread by airborne transmission. It has been suggested that a large inoculum might increase vaccine failure risk. Airbome transmission might occasionally entail a large measles inoculum. The epidemiologic relevance of measles among properly vaccinated persons (i.e., those vaccinated after 15 months of age and with live attenuated virus) is increased when they become contagious. The authors studied inoculum intensities as measured by proxy variables and the contagiousness of properly vaccinated persons who contracted measles among 51 measles patients infected in one school, at home, or elsewhere, utilizing preexisting records of measles cases and 214 healthy controls from an explosive school outbreak that occurred in a rural Finnish municipality in 1989. One “super-spreader” infected 22 others in one day, including eight once-vaccinated students and one twice-vaccinated student, probably during an assembly of 144 students in a poorly ventilated hallway with no sunlight. Those infected later at home had high measles risk, even if they were revaccinees. When siblings shared a bedroom with a measles case, a 78 percent risk (seven out of nine children) was observed among vaccinees. Vaccinees had approximately 2 days’ shorter incubation time than unvaccinated persons. Vaccinated and unvaccinated students were equally able to infect their siblings. Total protection against measles might not be achievable, even among revaccinees, when children are confronted with intense exposure to measles virus.”

#Shedding #Measles
#Vaccine #Failure

Failed rubella immunization in adults: association with immunologic and virological abnormalities.

“Immunologic and virological studies were performed in 13 adults (12 women and one man) who failed to seroconvert (as shown by rubella hemagglutination-inhibition [HAI] techniques) after single or repeated courses of HPV-77 DE/5 or RA 27/3 rubella virus vaccine.”

“In addition, rubella virus was isolated from three individuals by using cocultivation techniques with peripheral blood mononuclear cells. ”

#Rubella #Vaccine #Failure #MedScienceResearch

The failure of an inactivated mink enteritis virus vaccine in four preparations to provide protection to dogs against challenge with canine parvovirus-2.

#Vaccine #Failure #Parvo #Veterinary #Animals #MedScienceResearch

Failure of inactivated influenza A vaccine to protect healthy children aged 6-24 months.

“Inactivated influenza vaccine did not reduce the attack rate of influenza A infection in 6-24 month old children.”

#Flu #Vaccine #Failure #Influenza

Failure to reach the goal of measles elimination. Apparent paradox of measles infections in immunized persons.

#Measles #Vaccine #Failure #MedScienceResearch

Fever and multisystem organ failure associated with 17D-204 yellow fever vaccination: a report of four cases.

“In 1998, the US Centers for Disease Control and Prevention was notified of three patients who developed severe illnesses days after yellow fever vaccination. A similar case occurred in 1996. All four patients were more than 63 years old.

METHODS: Vaccine strains of yellow fever virus, isolated from the plasma of two patients and the cerebrospinal fluid of one, were characterised by genomic sequencing. Clinical samples were subjected to neutralisation assays, and an immunohistochemical analysis was done on one sample of liver obtained at biopsy.

FINDINGS: The clinical presentations were characterised by fever, myalgia, headache, and confusion, followed by severe multisystemic illnesses. Three patients died. Vaccine-related variants of yellow fever virus were found in plasma and cerebrospinal fluid of one vaccinee. The convalescent serum samples of two vaccinees showed antibody responses of at least 1:10240. Immunohistochemical assay of liver tissue showed yellow fever antigen in the Kuppfer cells of the liver sample.”

#Death #Vaccine #Failure #Yellow #Fever #MedScienceResearch

🛑 Finding the ‘who’ in whooping cough: vaccinated siblings are important pertussis sources in infants 6 months of age and under.

“At its peak, siblings were the most important sources of pertussis in infants 6 months and younger, particularly fully vaccinated children aged 2 and 3 years. Waning immunity before the booster at 4 years may leave this age group susceptible to infection.”

#Pertussis #Vaccine #Failure
#Waning #Immunity

Haemophilus influenzae type b meningitis in a vaccinated and immunocompetent child.

#Hib #Vaccine #Failure #MedScienceResearch

Haemophilus influenzae Type b Meningitis in the Short Period after Vaccination: A Reminder of the Phenomenon of Apparent Vaccine Failure.

“We present two cases of bacterial meningitis caused by Haemophilus influenzae type b (Hib) which developed a few days after conjugate Hib vaccination. This phenomenon of postimmunization provocative time period is reviewed and discussed. These cases serve as a reminder to clinicians of the risk, albeit rare, of invasive Hib disease in the short period after successful immunization.”

#Vaccine #Failure #Hib

? Hepatitis B Vaccines—to Switch or Not to Switch

“Shortly after the licensure of Heptavax-B in 1981 and its general availability in July 1982, the discovery of the acquired immunodeficiency syndrome (AIDS) among male homosexuals threatened the success of this product, since some of the hepatitis B surface antigen (HBsAg)-positive plasma donors were members of this high-risk group. Intensive epidemiologic, virological, and serological evaluations were launched, which eventually found no evidence for the transmission of AIDS to recipients of the plasma-derived HBsAg vaccine.”

#AIDS #HIV #Hepatitis B #Contamination #Vaccine

Herpes zoster due to Oka vaccine strain of varicella zoster virus in an immunosuppressed child post cord blood transplant.

#Shingles #Shedding
#Vaccine #Failure #MedScienceResearch

Herpes zoster in an adult recipient of live attenuated varicella vaccine.

#Shingles #Vaccine #Failure #MedScienceResearch

High diversity of poliovirus strains isolated from the central nervous system from patients with vaccine-associated paralytic poliomyelitis.

#Polio #Neurological
#Vaccine #Failure

High rate of vaccine failure after administration of acellular pertussis vaccine pre- and post-liver transplantation in children at a children’s hospital in Japan.

#Pertussis #Vaccine #Failure #MedScienceResearch

Horizontal transmission of a human rotavirus vaccine strain-a randomized, placebo-controlled study in twins.

#Shedding #Rotavirus #Vaccine #Failure #MedScienceResearch

Horizontal transmission of the Leningrad-Zagreb mumps vaccine strain: a report of six symptomatic cases of parotitis and one case of meningitis.

“Here we report horizontal symptomatic transmission of the Leningrad-Zagreb (L-Zagreb) mumps vaccine virus. Children who were the source of transmission had been vaccinated with the MMR vaccine (Serum Institute of India) contained L-Zagreb mumps virus. This is the first report of horizontal symptomatic transmission of this vaccine. The etiology of all seven contact cases was confirmed by epidemiological linking, serology and by F, SH, NP and HN mumps virus genes sequencing.”

#Shedding #Mumps #Meningitis
#Vaccine #Failure #MMR

Immune persistence after pertussis vaccination.

“An increased prevalence of pertussis in older populations has been found, mainly caused by waning immunity after vaccination.”

#Pertussis #DTP #DTaP #Vaccine #Failure #MedScienceResearch

Interference of Vaccine Derived Polio Viruses with Diagnosis of Enteroviral Diseases in Neonatal Period.

“OPV vaccinated neonates commonly pass the vaccine virus in their pharynx and stool which can be mistaken with NPEV.”

#Shedding #Polio #Vaccine #Failure #MedScienceResearch

Invasive pneumococcal disease: From a tertiary care hospital in the post-vaccine era.

#Vaccine #Failure #MedScienceResearch

A large vaccine-derived poliovirus outbreak on Madura Island-Indonesia, 2005.

“Between June and October 2005, 45 laboratory-confirmed type 1 vaccine-derived poliovirus (VDPV) cases were identified on Madura Island in Indonesia. Genetic sequencing data on VDPV isolates were consistent with replication and circulation for up to approximately 2 years. Concurrent circulation with type 1 wild poliovirus (WPV) enabled comparisons of VDPV and WPV cases and found that clinical and epidemiological features of both were similar. Attack rates for VDPV were as high as those for WPV. Of 41 VDPV case patients with known vaccination status, 25 (61%) had received zero oral polio vaccine (OPV) doses.”

#Polio #Vaccine #Failure

Late vitamin K deficiency bleeding after intramuscular prophylaxis at birth: a case report.

#Vitamin K #Failure #MedScienceResearch


“Regretfully, the story of polio vaccine was not without tragedy. In April 1955, soon after mass polio vaccination began in the United States, reports trickled in to the Surgeon General concerning atypical cases of paralytic polio. Several paralytic polio cases were reported in California in patients who had received the polio vaccine about a week earlier but the paralysis only affected the arm or leg in which they received the injection. Each of these cases occurred in polio vaccine produced by Cutter pharmaceutical company. The Surgeon General immediately pulled all Cutter polio vaccine, but it was too late; nearly 400,000 children had been inoculated with Cutter polio vaccine and 250 cases of atypical paralytic polio occurred. There were also reports of the Wyeth pharmaceutical company polio vaccine causing paralysis and death in several children in the northeastern United States.

It was soon discovered that some lots of Cutter and Wyeth polio vaccine were insufficiently inactivated with formalin leading to live polio virus in more than 100,000 doses. In fact, 16 lots of Cutter polio vaccine were retested and the first 6 lots produced were positive for live polio virus. These incidents demonstrated the lack of oversight and safeguards put into place before the vaccine was made so widely available.”

#Polio #Vaccine #Failure
#Cutter #Paralysis
#Incomplete #Inactivation

Live attenuated varicella vaccine: evidence that the virus is attenuated and the importance of skin lesions in transmission of varicella-zoster virus. National Institute of Allergy and Infectious Diseases Varicella Vaccine Collaborative Study Group.

“To examine whether the live varicella vaccine virus is attenuated, we analyzed varicella vaccine-induced contact cases of clinical chickenpox in healthy siblings of immunized children with leukemia. A rash developed approximately 1 month later in 156 children with leukemia who had been vaccinated. Vaccine-type virus was isolated from 25 of these children. Of 88 known susceptible healthy siblings who were exposed to a vaccine with a rash and from whom follow-up information was available, there was evidence of infection in 15 (17%). Of 15 siblings with seroconversion, 11 (73%) also acquired a mild rash with an average of 38 lesions and no accompanying systemic symptoms. Vaccine-type virus was isolated from four of the contact siblings. Tertiary transmission was documented once. Contact siblings with seroconversion were protected during future household exposure to chickenpox, which occurred in four instances.”

#Shedding #Varicella #Chickenpox #Vaccine #Failure #MedScienceResearch

Local public health response to vaccine-associated measles: case report.

“A five-year-old Canadian-born boy with a history of a hematopoetic stem cell transplant three years previously received live attenuated measles, mumps, and rubella (MMR) vaccine. Over the subsequent 7 to 14 days, he developed an illness clinically consistent with measles. There was no travel history or other measles exposure. Serology and polymerase chain reaction (PCR) testing confirmed acute measles infection.”

#Measles #Vaccine #Failure #MMR #MedScienceResearch

Low vaccine efficacy of mumps component among MMR vaccine recipients in Chennai, India

“These facts inevitably state that MMR vaccine failed to offer protection in vaccinated individuals against mumps infection.”

#Mumps #MMR #Failure #Vaccine #MedScienceResearch

A limited measles outbreak in a highly vaccinated US boarding school.

#Measles #Vaccine #Failure #MedScienceResearch

Live, attenuated varicella zoster vaccination of an immunocompromised patient.

#Shingles #Varicella #Zoster #Vaccine #Failure #MedScienceResearch

Major measles epidemic in the region of Quebec despite a 99% vaccine coverage

“Vaccination coverage for the total population was 99.0%. Incomplete vaccination coverage is not a valid explanation for the Quebec City measles outbreak.”

#Measles #Vaccine #Failure #MedScienceResearch

Measles outbreak in a fully immunized secondary-school population.

#Measles #Vaccine #Failure #MedScienceResearch

A measles outbreak in a middle school with high vaccination coverage and evidence of prior immunity among cases, Beijing, P.R. China.

#Measles #Vaccine #Failure #MedScienceResearch

Measles outbreak in a vaccinated population in Dhankutta.

“A measles outbreak occurred in Dhankutta town in year 2056 Falgun to 2057 Baishak (3 months). A total of 130 cases were registered at the Dhankutta District Hospital. A large proportion of the cases had severe disease with complications and were admitted at the hospital. None of the patients registered at the hospital died. Interestingly, 50.0% of cases were in higher age group (10 years and above) which is an unusual trend in developing countries. All the cases gave history of measles vaccination, which points towards the need for investigation of vaccine efficacy and cold chain efficiency.”

#Measles #Vaccine #Failure #MedScienceResearch

Mechanism of Injury-Provoked Poliomyelitis

#Polio #Failure #Paralysis #Neurological #Vaccine #MedScienceResearch

Modified chickenpox in children immunized with the Oka/Merck varicella vaccine.

#Varicella #Chickenpox #Vaccine #Failure #MedScienceResearch

Molecular typing of canine parvovirus strains circulating from 2008 to 2012 in an organized kennel in India reveals the possibility of vaccination failure.

#Parvo #Vaccine #Failure #Veterinary #Animals #MedScienceResearch

MRI findings in an infant with vaccine-associated paralytic poliomyelitis.

“We report a Brazilian infant who developed VAPP 40 days after receiving the first dose of oral polio vaccine (OPV). MR images of the cervical and thoracic spinal cord showed lesions involving the anterior horn cell, with increased signal intensity on T2-weighted sequences. We would like to emphasize the importance of considering VAPP as a differential diagnosis in patients with acute flaccid paralysis and an MRI showing involvement of medulla oblongata or spinal cord, particularly in countries where OPV is extensively administered.”

#Polio #Vaccine #Failure #Paralysis #Neurological #MedScienceResearch

[Mumps epidemic in vaccinated children in West Switzerland].

#Mumps #Vaccine #Failure #MMR #MedScienceResearch

🛑 [Mumps vaccine virus transmission].

“In this work we report the mumps vaccine virus shedding based on the laboratory confirmed cases of the mumps virus (MuV) infection. The likely epidemiological sources of the transmitted mumps virus were children who were recently vaccinated with the mumps vaccine containing Leningrad-Zagreb or Leningrad-3 MuV. The etiology of the described cases of the horizontal transmission of both mumps vaccine viruses was confirmed by PCR with the sequential restriction analysis.”

#Mumps #Vaccine #Failure #Shedding #MedScienceResearch

Neonatal paralytic poliomyelitis. A case report.

“We report a child who became symptomatic with apnea at 18 days of age and who subsequently developed a permanent monoparesis. Serologic and cultural evidence indicated the virus as poliovirus vaccine type. Another infant who received live oral poliovirus vaccine was probably the source of the infecting virus.”

#Shedding #Polio
#Recently #Vaccinated
#Paralysis #Apnea
#Respiratory #Vaccine #Failure

Neurologic complications in oral polio vaccine recipients.

“A vaccine-like strain of poliovirus was isolated from each patient, and each had symptoms (left leg paralysis in three; developmental regression, spasticity, and progressive fatal cerebral atrophy in one) persisting for at least 6 months.”

#Polio #Neurological #Neurodevelopmental #Paralysis #Vaccine #Failure #MedScienceResearch

Outbreak of aseptic meningitis associated with mass vaccination with a urabe-containing measles-mumps-rubella vaccine: implications for immunization programs.

#Meningitis #MMR #Measles #Mumps #Rubella #Vaccine #Failure #MedScienceResearch

Outbreak of measles among persons with prior evidence of immunity, New York City, 2011.

#Measles #Vaccine #Failure

Outbreak of pertussis in highly immunized adolescents and its secondary spread to their families.

“An outbreak of pertussis was recognized in a highly immunized sixth-grade class of schoolchildren. Among 43 children aged 11-12 years in the class, 38 had been immunized with three doses or more of DTP containing whole-cell pertussis vaccine, two with two doses of DTP and three children were unimmunized. The last DTP vaccines had been given 6-10 years before the outbreak. A total of eight children with pertussis suffering paroxysmal coughing attacks for 3 weeks or more were identified, seven being fully immunized and one unimmunized. Among the eight cases, two were confirmed by both culture and serology and one by serology alone. The attack rate in fully immunized children was 18.4% (7/38). Secondary spread of pertussis was identified in five of the households from which the eight patients originated. A total of six cases of pertussis from these five households were identified, and two of these were culture-confirmed. These observations suggest that vaccine-induced immunity weakens considerably 6-10 years after vaccination, and that booster immunization with DTP instead of DT is therefore recommended for the control of pertussis.”

#Pertussis #Vaccine #Failure
#DTP #Whooping #Cough
#Waning #Immunity #MedScienceResearch

Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus.

“An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.”

#Shedding #Death #Polio
#Recently #Vaccinated
#Vaccine #Failure #Paralysis

An outbreak of varicella in elementary school children with two-dose varicella vaccine recipients-Arkansas, 2006.

“Varicella vaccination coverage was 97%.”

#Varicella #Chickenpox #Vaccine #Failure #MedScienceResearch

Paralytic poliomyelitis associated with the Sabin 3 revertant strain of poliovirus in Bahrain.

#Polio #Vaccine #Failure #Paralysis #MedScienceResearch

Pertussis epidemic despite high levels of vaccination coverage with acellular pertussis vaccine. 2015

“Despite high levels of vaccination coverage, pertussis circulation cannot be controlled at all. The results question the efficacy of the present immunization programmes.”

#Pertussis #Vaccine #Failure

Pertussis: History of the Disease and Current Prevention Failure.

#Pertussis #DTP #Failure #Vaccine #MedScienceResearch

Pertussis outbreak in US elementary school with high vaccination coverage.

#Pertussis #Vaccine #Failure

Pneumococcal vaccine failure: can it be a primary immunodeficiency?

“We present the case of a 4-year-old boy, with complete antipneumococcal vaccination, who had necrotising pneumonia with pleural effusion and severe pancytopaenia with need for transfusion. A vaccine-serotype Streptococcus pneumoniae was isolated in the blood culture. On follow-up, detailed medical history, laboratory and genetic investigation led to the diagnosis of X linked dyskeratosis congenita.”

#Vaccine #Failure #Pneumonia #Pneumococcal

A Pneumonia Case Associated with Type 2 Polio Vaccine Strains.

#Polio #Vaccine #Failure #Pneumonia #Respiratory #MedScienceResearch;year=2017;volume=130;issue=1;spage=111;epage=112;aulast=Li

🛑 Polio programme: let us declare victory and move on.

“In 2011, there were an extra 47,500 new cases of NPAFP. Clinically indistinguishable from polio paralysis but twice as deadly, the incidence of NPAFP was directly proportional to doses of oral polio received. Though this data was collected within the polio surveillance system, it was not investigated.”

#Polio #Failure #Corruption #Vaccine #MedScienceResearch

Poliovirus Infections in Four Unvaccinated Children — Minnesota, August-October 2005

“On September 29, 2005, the Minnesota Department of Health (MDH) identified poliovirus type 1 in an unvaccinated, immunocompromised infant girl aged 7 months (the index patient) in an Amish community whose members predominantly were unvaccinated for polio. The patient has no paralysis; the source of the patient’s infection is unknown. Subsequently, poliovirus infections in three other children within the index patient’s community have been documented.”

“Partial sequencing of the virus capsid protein coding region (VP1) of the poliovirus genome at the MDH laboratory identified it as a vaccine-derived poliovirus (VDPV). VDPVs are poliovirus strains derived from one of the three Sabin poliovirus strains in oral polio vaccine (OPV) that have >1% difference in nucleotide sequence from the prototype vaccine virus.”

#Recently #Vaccinated #Shedding #Polio #Gastrointestinal #Vaccine #Failure #MedScienceResearch

[Post-licensure safety surveillance for Prevenar 13(®) in France].

“RESULTS: In 4 years and 4 months, 376 AEs, including 252 severe (67%), were recorded, 83 of which occurred following an injection of Prevenar 13(®) alone: 39 cutaneous AEs, 16 neurological AEs, four cases of collapse or shock, nine cases of fever, and one of thrombocytopenia. For the serious AEs, the outcome was favorable in 88% of cases and none of the 12 reported deaths were attributed to a side effect of vaccination. Fifty-nine cases of pneumococcal disease that suggest an ineffective vaccine were reported, but only 16 can be considered as a real failure of the vaccination.”

#Vaccine #Failure

Post-vaccinal distemper encephalitis in two Border Collie cross littermates.

#Encephalitis #Distemper #Veterinary #Animals #Neurological #Vaccine #Failure #MedScienceResearch

Post-vaccine measles in a child with concomitant influenza, Sicily, Italy, March 2015.

#Measles #Vaccine #Failure #MedScienceResearch

A prefecture-wide survey of mumps meningitis associated with measles, mumps and rubella vaccine.

“A survey of untoward reactions, especially central nervous system reactions, after the administration of a newly introduced measles, mumps and rubella (MMR) vaccine in Gunma Prefecture, Japan, was initiated soon after 4 patients were hospitalized for aseptic meningitis. Thirty-five, 6 and 2 children developed meningitis, convulsive disorders and parotitis, respectively, within 2 months after MMR vaccination during the 8-month period extending from April to November, 1989. The time lag between MMR vaccination and meningitis ranged from 14 to 28 days in the 35 cases of meningitis. Mumps virus, isolated from the cerebrospinal fluid in 13 patients with aseptic meningitis, was characterized by determination of the nucleotide sequences of the P gene as mumps vaccine strain. The incidence of aseptic meningitis with positive mumps vaccine virus was estimated to be 0.11% (0.3% as a whole) during the 8 months from April to November and increased to 0.3% (0.7% as a whole) in September and October. We conclude that the incidence of aseptic meningitis after MMR vaccination seems to be higher than that reported previously.”

#Mumps #Meningitis #Failure #MMR #Vaccine #MedScienceResearch

Questions regarding the safety and duration of immunity following live yellow fever vaccination.

“We found that antiviral immunity may be lost in 1-in-3 to 1-in-5 individuals within 5 to 10 years after a single vaccination and that children may be at greater risk for primary vaccine failure. The safety profile of YFV-17D was compared to other licensed vaccines including oral polio vaccine (OPV) and the rotavirus vaccine, RotaShield, which have subsequently been withdrawn from the US and world market, respectively. Expert commentary: Based on these results and recent epidemiological data on vaccine failures (particularly evident at >10 years after vaccination), we believe that current recommendations to no longer administer YFV-17D booster vaccination be carefully re-evaluated, and that further development of safer vaccine approaches should be considered.”

#Vaccine #Failure #Yellow #Fever #MedScienceResearch

[Recurrent meningitis and inherited complement deficiency].

“The first patient had four attacks of meningococcal meningitis and an episode of pneumonia of unknown aetiology in childhood. The second had six attacks of meningitis. He also suffered from recurrent infections (otitis media, tonsillitis, chronic mucopurulent rhinitis and subsequent pansinusitis complicated by nasal polyposis) since childhood. No autoimmune disease was documented in either patient. They both received meningococcal and pneumococcal vaccines.”

#Vaccine #Failure #Meningitis #Ear #Infection #Meningococcal #Pneumococcal #Pneumonia #MedScienceResearch

Reemergence of vaccinia virus during Zoonotic outbreak, Pará State, Brazil.

“In 2010, vaccinia virus caused an outbreak of bovine vaccinia that affected dairy cattle and rural workers in Pará State, Brazil. Genetic analyses identified the virus as distinct from BeAn58058 vaccinia virus (identified in 1960s) and from smallpox vaccine virus strains. These findings suggest spread of autochthonous group 1 vaccinia virus in this region.”

#Shedding #Smallpox
#Vaccine #Failure #Veterinary

A report of outbreaks of measles on the southern coast of Iran from 2009 to 2015. (2017)

“A high percentage of cases with measles in rural areas were reported in the areas which were covered by complete vaccination.”

#Measles #Vaccine #Failure

Review of accidents caused by incomplete inactivation of viruses.

Note: There is some speculation that this may be occurring with the influenza vaccine as well. More research is needed.

#Polio #Vaccine #Failure
#Formaldehyde #Cutter #Flu #Influenza #MedScienceResearch

Risk factors for measles vaccine failure among immunized students.

“An outbreak of measles occurred in a municipal school system which had reported 98% of students immunized against measles. A case-control study was conducted to determine reasons for vaccine failure. Vaccine failure was associated with immunizations that could not be documented in the provider’s records. Among children with provider-documented immunization, vaccine failure was associated with vaccination at 12 to 14 months of age with an odds ratio of 4.73. Among children vaccinated at 15 months or older, vaccine failure was not associated with time elapsed since vaccination. Studies should be conducted to determine whether unreliable immunization records are a more widespread problem. Further consideration should be given to routine revaccination of children previously vaccinated at 12 to 14 months of age.”

#Measles #Vaccine #Failure

Risks of reintroduction of polio after eradication: the vaccine origin of an outbreak of type 3 poliomyelitis.

“Sabin live-attenuated strains, which have proved to be the most effective tools for poliovirus eradication, could also be the source of reintroduction of polio epidemics after global eradication of wild poliomyelitis is achieved. There are still considerable gaps in our knowledge about the persistence of vaccine-derived viruses in the population and the mechanisms involved in poliovirus transmissibility, both of which are essential factors in assessing the risks posed by such strains and in designing effective strategies for the cessation of polio immunisation. In this report, we have examined virological and epidemiological aspects of an epidemic of poliomyelitis in 1968 in Poland that was shown to be associated with the use of the USOL-D-bac live-attenuated vaccine strain. Possible causes of the origin and progress of the outbreak included the pattern of virus excretion from vaccinees, mutations identified in epidemic viruses and the unique vaccination policies in Poland during the years preceding the epidemic.”

#Polio #Vaccine #Failure #Shedding #MedScienceResearch

Rotavirus shedding in premature infants following first immunization.

#Shedding #Rotavirus #Failure #Gastrointestinal #Premature #Vaccine #MedScienceResearch

Rotavirus vaccine-derived shedding and viral reassortants.

#Shedding #Rotavirus #Failure #Gastrointestinal #Vaccine #MedScienceResearch

Rotavirus vaccines: viral shedding and risk of transmission.

#Shedding #Rotavirus #Failure #Gastrointestinal #Vaccine #MedScienceResearch

Safety of live vaccinations on immunosuppressive therapy in patients with immune-mediated inflammatory diseases, solid organ transplantation or after bone-marrow transplantation - A systematic review of randomized trials, observational studies and case reports.

“However, some serious vaccine-related adverse events occurred. 32 participants developed an infection with the vaccine strain; in most cases the infection was mild. However, in two patients fatal infections were reported”

#Death #Vaccine #Failure
#MMR #Polio #Rotavirus #BCG #Varicella #Smallpox #Typhoid #Shingles #Yellow #Fever

Secondary measles vaccine failures identified by measurement of IgG avidity: high occurrence among teenagers vaccinated at a young age.

#Measles #Vaccine #Failure #MedScienceResearch

Secondary transmission of varicella vaccine virus in a chronic care facility for children.

“A 16-year-old varicella-seronegative resident at a chronic care facility received varicella vaccine; 15 days later he developed severe varicella. Subsequently, a 13-year-old resident and a 39-year-old health care worker developed mild varicella. We demonstrate that vaccine-strain virus was transmitted to both persons, and that transmission included at least 2 variant vaccine strains.”

#Shedding #Vaccine #Failure #Varicella #Chickenpox

Serotype-specific mucosal immune response and subsequent poliovirus replication in vaccinated children.

“In the case of poliovirus Type 3, about 10% of children were still excreting the vaccine virus 9 weeks after administering the third dose.”

#Shedding #Polio #Vaccine #Failure #MedScienceResearch

Severe combined immunodeficiency (SCID) and rotavirus vaccination: reports to the Vaccine Adverse Events Reporting System (VAERS).

“Stool rotavirus testing was positive in all cases and the virus was identified as the vaccine strain in six cases. Prolonged viral shedding was documented in five cases.”

#Shedding #Rotavirus
#Vaccine #Failure #Gastrointestinal
#VAERS #MedScienceResearch

Severe tetanus in immunized patients with high anti-tetanus titers.

#Failure #Tetanus #DTP #Vaccine #MedScienceResearch

Sibling transmission of vaccine-derived rotavirus (RotaTeq) associated with rotavirus gastroenteritis.

“Although rotavirus vaccines are known to be shed in stools, transmission of vaccine-derived virus to unvaccinated contacts resulting in symptomatic rotavirus gastroenteritis has not been reported to our knowledge. We document here the occurrence of vaccine-derived rotavirus (RotaTeq [Merck and Co, Whitehouse Station, NJ]) transmission from a vaccinated infant to an older, unvaccinated sibling, resulting in symptomatic rotavirus gastroenteritis that required emergency department care.”

#Unvaccinated #Shedding
#Vaccine #Failure #Gastrointestinal #Rotavirus #MedScienceResearch

Some ethical issues arising from polio eradication programmes in India.

“The issue of risks and benefits arises in relation to the choice between two different vaccine types available for polio programmes: oral polio vaccine (OPV) and inactivated polio vaccine (IPV). OPV is the vaccine currently used in the eradication campaign in India. We argue that given the current risks/benefits profile of this vaccine, there is an urgent need to review the programme and take remedial action to address existing problems (at least in India). The second issue we discuss is the fact that there is little effort to gain the informed consent of the parents of vaccinated children, as they are not currently told about the potential limitations of OPV or the possibility of vaccine-induced harm.”

#Polio #Vaccine #Failure #Corruption #MedScienceResearch

Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns.

#Failure #BCG #Vaccine #MedScienceResearch

Surveillance of suspected poliomyelitis in Albania, 1980-1995: suggestion of increased risk of vaccine associated poliomyelitis.

“Poliovirus was isolated from six subjects who were defined as contact vaccine-associated cases. Characterization of isolates by both antigenic and molecular methods showed that, in all cases, the disease was associated with type 2 or 3 polioviruses of vaccine origin with retromutations known to be associated with loss of Sabin attenuated phenotype. Infection occurred despite the fact that all patients had records of previous immunization with oral polio vaccine (OPV), suggesting a failure of vaccination.”

#Polio #Vaccine #Failure #MedScienceResearch

The total influenza vaccine failure of 1947 revisited: major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic.

#Flu #Vaccine #Failure #Influenza #MedScienceResearch

Transmission of imported vaccine-derived poliovirus in an undervaccinated community in Minnesota.

#Polio #Shedding #Failure #Vaccine #MedScienceResearch

Transmission of measles among a highly vaccinated school population-
Anchorage, Alaska, 1998.

“During August 10-November 23, 1998, 33 confirmed measles cases were reported to the Anchorage Department of Health and Human Services and the Alaska Department of Health and Social Services (ADHSS). Of these, 26 cases were confirmed by positive rubeola IgM antibody test, and seven met the clinical case definition. This was the largest outbreak of measles in the United States since 1996. This report summarizes results of the epidemiologic investigation conducted by ADHSS and underscores the importance of second-dose requirements for measles vaccine.”

#Measles #Vaccine #Failure
#Waning #Immunity #MedScienceResearch

Transmission of the L-Zagreb mumps vaccine virus, Croatia, 2005-2008.

“We report on three cases of symptomatic transmission of the L-Zagreb mumps vaccine virus from three vaccinated children to five adult contacts. The five contact cases were parents of the vaccinated children and presented with parotitis and in one case also with aseptic meningitis. The etiology of the contacts’ illness was determined by viral culture, genomic sequencing, serology and epidemiological linking. Two of the vaccinated children developed vaccine associated parotitis as an adverse event three weeks following immunization.”

#Shedding #Mumps #Meningitis
#Vaccine #Failure #MMR

Tuberculosis II: the failure of the BCG vaccine.

“Despite the questioning of its innocuousness and efficacy, the BCG vaccine was imposed worldwide in 1950 by medical and political organizations that showed no concern for these questions.”

#Vaccine #Failure #BCG #Corruption #Tuberculosis #MedScienceResearch

Tuberculosis in Newborns: The Lessons of the “LĂĽbeck Disaster” (1929-1933).
Fox GJ, et al. PLoS Pathog. 2016.

“In an accident later known as the LĂĽbeck disaster, 251 neonates were orally given three doses of the new Bacille Calmette-GuĂ©rin (BCG) antituberculosis (TB) vaccine contaminated with Mycobacterium tuberculosis. A total of 173 infants developed clinical or radiological signs of TB but survived the infection, while 72 died from TB.”

#Death #Vaccine #Failure #BCG #Tuberculosis #Contamination

Two successive outbreaks of mumps in Nova Scotia among vaccinated adolescents and young adults.

#Mumps #MMR #Vaccine #Failure #MedScienceResearch

Unexpectedly limited durability of immunity following acellular pertussis vaccination in preadolescents in a North American outbreak.

“CONCLUSIONS: Our data suggests that the current schedule of acellular pertussis vaccine doses is insufficient to prevent outbreaks of pertussis.”

#DTaP #Pertussis #Vaccine #Failure #MedScienceResearch

Update on Vaccine-Derived Polioviruses - Worldwide, January 2014-March 2015.

“Circulating VDPVs (cVDPVs) resemble WPVs and, in areas with low OPV coverage, can cause polio outbreaks. Immunodeficiency-associated VDPVs (iVDPVs) can replicate and be excreted for years in some persons with PIDs..

“Eight newly identified persons in six countries were found to excrete iVDPVs, and a patient in the United Kingdom was still excreting iVDPV2 in 2014 after more than 28 years.”

#Shedding #Polio #Vaccine #Failure #MedScienceResearch

Use of a novel real-time PCR assay to detect oral polio vaccine shedding and reversion in stool and sewage samples after a mexican national immunization day.

“During replication, oral polio vaccine (OPV) can revert to neurovirulence and cause paralytic poliomyelitis. In individual vaccinees, it can acquire specific revertant point mutations, leading to vaccine-associated paralytic poliomyelitis (VAPP). With longer replication, OPV can mutate into vaccine-derived poliovirus (VDPV), which causes poliomyelitis outbreaks similar to those caused by wild poliovirus. After wild poliovirus eradication, safely phasing out vaccination will likely require global use of inactivated polio vaccine (IPV) until cessation of OPV circulation.”

#Shedding #Polio #Paralysis
#Vaccine #Failure

[Vaccination failure: case report of Haemophilus influenzae b meningitis in a 14-month-old child].

“We described the case of a 14-months-old child showing a bacterial purulent meningitis with Hib, despite of a well driven vaccination.”

#Hib #Meningitis
#Vaccine #Failure

Vaccination to Alzheimer Disease. Is it a Promising Tool or a Blind Way?

“Unfortunately, the promising vaccines like the AN 1792 were halted during clinical trials because of adverse effects like meningoencephalitis.”

#Vaccine #Failure #Alzheimers #Neurological #MedScienceResearch


#Polio #Shedding #Death #Paralysis #Vaccine #Failure #MedScienceResearch

Vaccine-associated poliomyelitis in an infant with agammaglobulinemia.

#Polio #Vaccine #Failure #Shedding #MedScienceResearch

Vaccine-derived poliomyelitis and postpolio syndrome: an Italian Cutter Incident.

#Polio #Vaccine #Failure #Cutter #MedScienceResearch

Vaccine Failures in Patients Properly Vaccinated with 13-Valent Pneumococcal Conjugate Vaccine in Catalonia, a Region with Low Vaccination Coverage.

“Vaccine failures occurring with 13-valent pneumococcal conjugate vaccine (PCV13) in 3 pediatric hospitals in Barcelona (2012-2013) are described. PCV13 vaccine failure was defined as the occurrence of an invasive pneumococcal infection in children properly vaccinated by PCV13. Among 84 patients with invasive pneumococcal infection, 32 had received at least one dose of PCV13. Seventeen of them had invasive pneumococcal infection produced by a PCV13 serotype. Among those, 9 patients were considered to have a PCV13 vaccine failure. Serotype 3 was isolated in 6 patients, serotype 19A in 2 and serotype 6B in 1.”

#Pneumococcal #Vaccine #Failure #MedScienceResearch

Vaccine-induced polioencephalomyelitis in Scotland.

“A six-month-old British female, living in Glasgow was admitted in June 1986 with a four-day history of fever and lower limb weakness following immunisation with oral polio and triple (DTP) vaccines. Examination revealed paralysis of all limbs, facial muscles and right diaphragm, scoliosis, opsoclonus and ocular flutter. Poliovirus types 1, 2 and 3, isolated from her stool specimens were all vaccine-like strains.”

#Polio #Vaccine #Failure #Paralysis #MedScienceResearch

Vaccine-related adverse events in Cuban children, 1999-2008.

“The DTwP vaccine exhibited the highest rate of adverse events. Common minor events were: fever (17,538), reactions at injection site (4470) and systemic side effects (2422). Rare events (by WHO definition) reported were: persistent crying (2666), hypotonic-hyporesponsive episodes (3), encephalopathy (2) and febrile seizures (112). Severe events included: anaphylaxis (2), respiratory distress (1), multiple organ failure (1), sudden death (1), vaccine-associated paralytic poliomyelitis (2), toxic shock syndrome (3), and sepsis (1). The 10 deaths and 3 cases of disability were investigated by an expert commission, which concluded that 8 of the 13 severe events were vaccination-related.”

#Death #DTP #Seizures #HHE #Encephalopathy #Polio #Respiratory #Anaphylaxis #Neurological #Vaccine #Failure #MedScienceResearch

Vaccine-related mumps infections in Thailand and the identification of a novel mutation in the mumps fusion protein.

#Mumps #Vaccine #Failure #MedScienceResearch

Variability in Humoral Immunity to Measles Vaccine: New Developments.

“Despite the existence of an effective measles vaccine, resurgence in measles cases in the USA and across Europe has occurred, including in individuals vaccinated with two doses of the vaccine.”

#Measles #Failure #MMR
#HLA #Vaccine #MedScienceResearch

Varicella outbreak in a highly-vaccinated school population in Beijing, China during the voluntary two-dose era. (2017)

#Vaccine #Failure #Varicella #Chickenpox #MedScienceResearch

Varicella vaccination after fingolimod: A case report.

#Shedding #Varicella #Chickenpox #Shingles #Vaccine #Failure #MedScienceResearch

[Vitamin K deficiency bleeding in an infant despite adequate prophylaxis].

#Vitamin K #Failure #MedScienceResearch

What, in Fact, Is the Evidence That Vaccinating Healthcare Workers against Seasonal Influenza Protects Their Patients? A Critical Review

#Flu #Failure #Influenza #Vaccine #MedScienceResearch

What is the cause of a rash after measles-mumps-rubella vaccination?

“We describe a 17-month-old child with fever and rash after measles-mumps-rubella vaccination. Detection of vaccine-strain
measles virus in his urine by poly
merase chain reaction confirmed the diagnosis of a vaccine reaction rather than wild-type measles. We propose that measles virus should be sought and identified as vaccine or wild-type virus when the relationship between vaccination and measles-like illness is uncertain.”

#Vaccine #Failure #Shedding #MMR #Measles #MedScienceResearch

Why Do Pertussis Vaccines Fail?

#DTaP #DTP #Vaccine #Failure #Pertussis #MedScienceResearch