Scientific studies and articles from PubMed on vaccines and arthritis:

Adjuvants- and vaccines-induced autoimmunity: animal models.

“In some cases, adjuvants may trigger generalized autoimmune response, resulting in multiple auto-antibodies, but sometimes they can reproduce human autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, autoimmune thyroiditis and antiphospholipid syndrome and may provide insights about the potential adverse effects of adjuvants.”

#Thyroid #Arthritis #Lupus #Sjogren #Autoimmunity #Antiphospholipid #Animals #Veterinary #Musculoskeletal #Neurological #Vaccine

Autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine.

“This was a case study in which 3 patients with autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination (HPV) were evaluated and described. All the patients were women. Diagnosis consisted of HLA-B27 enthesitis related arthritis, rheumatoid arthritis and systemic lupus erythematous, respectively. Our results highlight the risk of developing ASIA after HPV vaccination and may serve to increase the awareness of such a complication. Factors that are predictive of developing autoimmune diseases should be examined at the population level in order to establish preventive measures in at-risk individuals for whom healthcare should be personalized and participatory.”

#Gardasil #ASIA #Autoimmunity #HLA #Arthritis #Lupus #Vaccine #MedScienceResearch

🛑 Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity.

#Thyroid #Autoimmunity #ASIA #HLA #Lupus #Arthritis #Hashimotos #Vaccine #MedScienceResearch

Full article:

Bivalent HPV vaccine safety depending on subtypes of juvenile idiopathic arthritis.

#Arthritis #Gardasil #Gastrointestinal #HPV #Autoimmunity #HLA
#Vaccine #MedScienceResearch

A case-control study of quadrivalent human papillomavirus vaccine-associated autoimmune adverse events.

“It was observed that cases with the SAAE outcomes of gastroenteritis (odds ratio (OR) = 4.6, 95% confidence interval (CI) = 1.3-18.5), arthritis (OR = 2.5, 95% CI = 1.4-4.3), systemic lupus erythematosus (OR = 5.3, 95% CI = 1.5-20.5), vasculitis (OR = 4, 95% CI = 1.01-16.4), alopecia (OR = 8.3, 95% CI = 4.5-15.9), or CNS conditions (OR = 1.8, 95% CI = 1.04-2.9) were significantly more likely than controls to have received HPV4 vaccine (median onset of SAAE symptoms from 6 to 55 days post-HPV4 vaccination).”

#Gardasil #Lupus #Arthritis #Autoimmunity #HPV #Hair #Loss
#Gastrointestinal #Alopecia #Neurological #Vaccine #MedScienceResearch

A case of systemic lupus erythematosus (SLE) following Human papillomavirus (HPV) vaccination.

“A 15-year-old young woman received the Human papillomavirus (HPV) vaccines. Following the second HPV vaccination, intermittent fever, myalgia, arthritis and malar rash developed, and she was admitted to our hospital. Laboratory studies showed positive results for antinuclear antibody, anti-dsDNA antibody and anti-Sm antibody. Systemic lupus erythematosus (SLE) was diagnosed according to the Systemic Lupus International Collaborative Clinics 2012. Magnetic resonance imaging showed abnormal hyperintense areas in the fascia, and en bloc biopsy showed fasciitis. Treatment with prednisolone resulted in an amelioration of the symptoms. Reportedly, SLE developed after HPV vaccinations in some patients. Most such patients have a past or family history of autoimmune disease and presented SLE symptoms after the second vaccination. We describe herein a patient in whom SLE developed in association with HPV vaccination.”

#Gardasil #Lupus #SLE #HPV #Autoimmunity #Arthritis #Musculoskeletal #Vaccine

The development of rheumatoid arthritis after recombinant hepatitis B vaccination.

#Rheumatoid #Arthritis
#Hepatitis B #Autoimmunity #Vaccine #MedScienceResearch

Mycobacterial Arthritis at 19 Months After a Bacille Calmette-Guérin Vaccination. (2017)

“A 20-month-old afebrile boy living in northern Taiwan presented with swelling of the right knee for 5 days. No other respiratory or gastrointestinal symptoms were associated. A bacille Calmette–Guérin (BCG) vaccination had been performed when he was 1 month of age. The X-ray showed no bony destruction, and the sonography revealed some fluid accumulation in the right suprapatellar pouch. Arthrocentesis was performed, and characteristically cream-colored pus was drained (Figure 1 ). The knee swelling persisted, and magnetic resonance imaging showed abscess formation in the right suprapatellar bursa (Figures 2 and ​and33 ). Furthermore, surgical debridement was performed, and histological examination revealed granulomatous inflammation with caseation necrosis. The pus culture yielded Mycobacterium bovis. The patient was immunocompetent and was administered with isoniazid and rifampicin. He recovered without complications.

Tuberculosis remains an important health threat and the live attenuated BCG vaccine was used to prevent childhood tuberculosis. In 2009, the annual incidence of tuberculosis in Taiwan was approximately 69 cases/100,000 persons, and the Tokyo-172 BCG vaccination was included in the national immunization program with a coverage rate of 97%.1,2 BCG-related arthritis and osteitis is a rare but severe complication.3 The lower extremities are most commonly involved.4 The estimated incidence rates of BCG-related osteitis/osteomyelitis vary with place, time, and vaccine strain; for example, two cases per million vaccinations in Japan and 30 cases per million vaccinations in Finland.4,5 In Taiwan, the incidence was 12.9 cases per million vaccinations during 2005–2007.2 Pediatricians should remain alert for mycobacterial infections in children with BCG vaccination, including those administered long before presentation of arthritis, such as 19 months in the present patient. Early diagnosis and correct treatment are crucial for successful treatment.”

#Arthritis #BCG #Autoimmunity #Vaccine #MedScienceResearch

Occurrence of severe destructive lyme arthritis in hamsters vaccinated with outer surface protein A and challenged with Borrelia burgdorferi.

“When the canine rOspA vaccine was combined with aluminum hydroxide, all vaccinated hamsters developed arthritis after challenge with B. burgdorferi sensu stricto. Histopathologic examination confirmed the development of severe destructive arthritis in rOspA-vaccinated hamsters challenged with B. burgdorferi sensu stricto. These findings suggest that rOspA vaccines should be modified to eliminate epitopes of OspA responsible for the induction of arthritis. Our results are important because an rOspA vaccine in aluminum hydroxide was approved by the Food and Drug Administration for use in humans.”

#Lyme #Arthritis #Aluminum #Borrelia #Vaccine #Autoimmunity #MedScienceResearch

A one year followup of chronic arthritis following rubella and hepatitis B vaccination based upon analysis of the Vaccine Adverse Events Reporting System (VAERS) database.

#Arthritis #Hepatitis B #Rubella #Vaccine #Autoimmunity #MedScienceResearch

Postpartum rubella immunization: association with development of prolonged arthritis, neurological sequelae, and chronic rubella viremia.

#Shedding #Breastfeeding #Arthritis #Rubella #Neurological
#Vaccine #MedScienceResearch

Reactive arthritis after influenza vaccination: report of a case.

“We describe a patient with reactive arthritis (ReA) induced by influenza vaccination. A healthy 79-year-old Japanese man began suffering from migrating polyarthritis 2 days after receiving influenza vaccine. He proved negative for rheumatoid factor, showing no evidence for microbial infections such as Streptoccocci, Chlamydia, or Parbovirus B19. Human leukocyte antigen (HLA) typing analysis revealed positive results for HLA-B54 (22), which is one of the cross-reactive antigens to HLA-B27. His arthritis improved with administration of nonsteroidal anti-inflammatory drugs, and recovery was attained within 6 weeks. Reactive arthritis is a rare adverse effect induced by influenza vaccination; however, it is important that it is recognized by all physicians.”

#Arthritis #HLA #Influenza #Vaccine #MedScienceResearch

Severe Autoimmune Adverse Events Post Herpes Zoster Vaccine: A Case-Control Study of Adverse Events in a National Database.

“Our study showed no significantly increased risks of severe autoimmune adverse events, except arthritis and alopecia, after vaccination.”

#Hair #Loss #Arthritis #Alopecia #Shingles #Herpes #Zoster #Vaccine #MedScienceResearch

Vaccinations and risk of systemic lupus erythematosus and rheumatoid arthritis: A systematic review and meta-analysis.

“The pooled findings suggested that vaccinations significantly increased risk of SLE (RR=1.50; 95%CI 1.05-2.12, P=0.02). In addition, there was an obvious association between vaccinations and increased risk of RA (RR=1.32; 95%CI 1.09-1.60, P=0.004). Meta-analysis of studies reporting outcomes of short vaccinated time also suggested that vaccinations could significantly increase risk of SLE (RR=1.93; 95%CI 1.07-3.48, P=0.028) and RA (RR=1.48; 95%CI 1.08-2.03, P=0.015).”

#Lupus #Arthritis #Autoimmunity
#Vaccine #MedScienceResearch