Pneumococcal

Hypotonic hyporesponsive episode and the 13-valent pneumococcal vaccine.

“Hypotensive-hyporesponsive episodes are rare events after immunizations performed for diphtheria, tetanus, Haemophilus influenzae type b and hepatitis B virus vaccines, but most of the reported episodes have been associated with pertussis-containing vaccines. We report the case of a 3-month-old girl, previously healthy otherwise, presenting with the unusual event of a hypotonic-hyporesponsive episode after vaccination with the 13-valent pneumococcal vaccine. Diagnosis was established after a thorough evaluation of the patient and by exclusion of other clinical conditions.”

Note: “A hypotonic-hyporesponsive episode (HHE) is a sudden and unexpected episode of loss of tone, unresponsiveness and colour change which uncommonly affects infants and children after vaccination.” – MS Gold, PubMed

#HHE #Near #Miss #Pneumococcal #Hypotensive #Hyporesponsive #Episode #Pertussis #Vaccine
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25818964/

? Hypotonic-hyporesponsive episode in a 7-month-old infant after receipt of multiple vaccinations.

“A 7-month-old boy became difficult to arouse, was limp and had blue extremities 8 hours after immunization with intravenous poliovirus, diphtheria-tetanus toxoids-acellular pertussis, Haemophilus influenzae type b-hepatitis B virus and pneumococcal vaccines. The hypotonic-hyporesponsive episode had resolved by the time the infant was seen in an emergency department 1 hour later. The report describes hypotonic-hyporesponsive episode, encourages reporting of vaccine-associated adverse events and discusses prognosis and implications for subsequent immunization.”

#Hypotonic #Hyporesponsive #HHE #Polio #DTaP #Hib #Hepatitis B #Pneumococcal
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/16282941/

Injection Site Lichenoid Dermatitis Following Pneumococcal Vaccination: Report and Review of Cutaneous Conditions Occurring at Vaccination Sites.

“Basal cell carcinoma and squamous cell carcinoma are the most common vaccination site-associated malignancies; however, melanoma and sarcomas (dermatofibrosarcoma protuberans, fibrosarcoma, and malignant fibrous histiocytoma) are also smallpox vaccine-related site neoplasms.”

#Dermatological #Cancer #Pneumococcal #Smallpox #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/26988991/

Invasive pneumococcal disease: From a tertiary care hospital in the post-vaccine era.

#Pneumococcal #Vaccine #Failure #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/27905836/

Pneumococcal vaccine failure: can it be a primary immunodeficiency?

“We present the case of a 4-year-old boy, with complete antipneumococcal vaccination, who had necrotising pneumonia with pleural effusion and severe pancytopaenia with need for transfusion. A vaccine-serotype Streptococcus pneumoniae was isolated in the blood culture. On follow-up, detailed medical history, laboratory and genetic investigation led to the diagnosis of X linked dyskeratosis congenita.”

#Vaccine #Failure #Pneumonia #Pneumococcal
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/24925540/

[Post-licensure safety surveillance for Prevenar 13(®) in France].

“RESULTS: In 4 years and 4 months, 376 AEs, including 252 severe (67%), were recorded, 83 of which occurred following an injection of Prevenar 13(®) alone: 39 cutaneous AEs, 16 neurological AEs, four cases of collapse or shock, nine cases of fever, and one of thrombocytopenia. For the serious AEs, the outcome was favorable in 88% of cases and none of the 12 reported deaths were attributed to a side effect of vaccination. Fifty-nine cases of pneumococcal disease that suggest an ineffective vaccine were reported, but only 16 can be considered as a real failure of the vaccination.”

#Pneumococcal
#Vaccine #Failure
#Thrombocytopenia
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/28242152/

Preparation for global introduction of inactivated poliovirus vaccine: safety evidence from the US Vaccine Adverse Event Reporting System, 2000-12.

“Of the 41,792 adverse event reports submitted, 39,568 (95%) were for children younger than 7 years. 38,381 of the reports for children in this age group (97%) were for simultaneous vaccination with IPV and other vaccines (most commonly pneumococcal and acellular pertussis vaccines), whereas standalone IPV vaccines accounted for 0·5% of all reports. 34,880 reports were for non-serious events (88%), 3905 reports were for non-fatal serious events (10%), and 783 reports were death reports (2%). Injection-site erythema was the most commonly coded term for non-serious events (29%), and pyrexia for non-fatal serious events (38%). Most deaths (96%) were in children aged 12 months or younger; most (52%) had sudden infant death syndrome as the reported cause of death.”

#SIDS #Sudden #Infant #Death #Polio #Vaccine #Pneumococcal #DTaP #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/26289956/

[Recurrent meningitis and inherited complement deficiency].

“The first patient had four attacks of meningococcal meningitis and an episode of pneumonia of unknown aetiology in childhood. The second had six attacks of meningitis. He also suffered from recurrent infections (otitis media, tonsillitis, chronic mucopurulent rhinitis and subsequent pansinusitis complicated by nasal polyposis) since childhood. No autoimmune disease was documented in either patient. They both received meningococcal and pneumococcal vaccines.”

#Vaccine #Failure #Meningitis #Ear #Infection #Meningococcal #Pneumococcal #Pneumonia #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/28078901/

Vaccination with 10-valent pneumococcal conjugate vaccine in infants according to HIV status.

“One death (sudden infant death syndrome; HEU group; 3 days post-dose 1) was considered potentially vaccine-related.”

#Sudden #Infant #Death #Syndrome #SIDS #Pneumococcal
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/28079828/

Vaccine Failures in Patients Properly Vaccinated with 13-Valent Pneumococcal Conjugate Vaccine in Catalonia, a Region with Low Vaccination Coverage.

“Vaccine failures occurring with 13-valent pneumococcal conjugate vaccine (PCV13) in 3 pediatric hospitals in Barcelona (2012-2013) are described. PCV13 vaccine failure was defined as the occurrence of an invasive pneumococcal infection in children properly vaccinated by PCV13. Among 84 patients with invasive pneumococcal infection, 32 had received at least one dose of PCV13. Seventeen of them had invasive pneumococcal infection produced by a PCV13 serotype. Among those, 9 patients were considered to have a PCV13 vaccine failure. Serotype 3 was isolated in 6 patients, serotype 19A in 2 and serotype 6B in 1.”

#Pneumococcal #Vaccine #Failure #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/26658626