Dermatological

Anetoderma occurring after hepatitis B vaccination.

“Anetoderma is an elastolytic disorder of unknown origin. To our knowledge, anetoderma secondary to hepatitis B immunization has been described only once in the literature, in two siblings vaccinated at the same time. We describe, what we believe to be an additional case of such a rare disorder in a 21-year-old man. He presented with white spots and papules on his neck, upper limbs and trunk, that had developed gradually within the last 6 years without any symptoms. The initial lesions were red macules, which gradually enlarged in size and number, becoming pale. Biopsy of a sack-like lesion revealed normal epidermis and a discrete mononuclear infiltrate throughout the dermis. Association of anetoderma with hepatitis B vaccination is speculated here, as suggested by history of vaccination two weeks prior to the onset of skin eruption and ruling out other possible causes of anetoderma.”

#Dermatological #Hepatitis B #Anetoderma #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/16880577/

Basal-cell epithelioma occurring in a smallpox vaccination scar.

“A patient with basal-cell epithelioma occurring in a smallpox vaccination site is reported. The association is probably not a chance occurrence.”

#Cancer #Smallpox #Dermatological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/932293/

Borderline tuberculoid leprosy following BCG vaccination. A case report.

“Borderline tuberculoid leprosy was diagnosed clinically and histologically in a four year-old boy about 6 months after intradermal vaccination with BCG. His mother reported that a lesion began to appear above the vaccination site on the arm 2 weeks after the vaccination, and a second lesion appeared on the chin 2 months later. Responses in the lymphocyte transformation test to sonicated Mycobacterium leprae, BCG, and to PPD were consistent with a tuberculoid leprosy infection. Precipitation of BT leprosy by intradermal BCG infection may possibly represent the overcoming of a phase of primary suppression in an individual who might otherwise have progressed toward lepromatous leprosy. The implications of this hypothesis for the planning of a controlled trial of an anti-leprosy vaccine are discussed.”

#Leprosy #BCG #Dermatological
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/7195879/

[Cancer on a smallpox vaccination scar].

“A 52 year old housewife was vaccinated against smallpox at the age of 18, on her right deltoid area. At the age of 50 she noticed erythema and scaling on the vaccination scar and 2 years later a nodule appear that enlarged during the following 3 months. There was no history nor skin changes suggestive of significant sun exposure. The histological examination of an initial biopsy and of the subsequently excised lesion revealed a basal cell carcinoma of the solid type.”

#Cancer #Smallpox #Dermatological
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/5712979/

A Case of Sudden Infant Death Due to Incomplete Kawasaki Disease.

“In our 5-month-old case, he had been admitted to a hospital for a fever and suppuration at the site of Bacille de Calmette et Guerin (BCG) vaccination.”

#BCG #Dermatological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/26347043/

Characterisation of poxviruses from sporadic human infections.

“An orthopoxvirus was isolated from the vesicular rash of a man in Natal who died in coma and who had not been vaccinated. Analysis of the viral DNA showed that it was a vaccinia virus, more closely related to the virus of South African smallpox vaccine than to other vaccinia viruses.”

“Minor biological differences between the viruses isolated and the corresponding vaccine strains suggested that some natural transmission of the virus had occurred, but the results of DNA analysis implied that they originated from the use of smallpox vaccine.”

#Shedding #Death #Smallpox #Dermatological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/2892275/

Eczema vaccinatum resulting from the transmission of vaccinia virus from a smallpox vaccinee: an investigation of potential fomites in the home environment.

“On March 3, 2007, a 2-year-old boy was hospitalized with eczema vaccinatum. His two siblings, one with eczema, were subsequently removed from the home. Swabs of household items obtained on March 13th were analyzed for orthopoxvirus DNA signatures with real-time PCR. Virus culture was attempted on positive specimens. Eight of 25 household samples were positive by PCR for orthopoxvirus; of these, three yielded viable vaccinia virus in culture. Both siblings were found to have serologic evidence of orthopoxvirus exposure.”

#Shedding #Eczema #Smallpox #Dermatological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/19027813/

Erythema multiforme following vaccination for human papillomavirus.

#HPV #Gardasil #Vaccine #Immune #Dermatological
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/19887766/

Exacerbation of pemphigus after influenza vaccination.

“Pemphigus is a rare autoimmune disease characterized by flaccid blisters and erosions on skin and mucous epithelia. A critical event in its pathogenesis is production of antidesmoglein antibodies, which mediate the loss of intercellular adhesion in epithelia, leading to blister formation. Multiple environmental factors (ultraviolet radiation, trauma, drugs, infective agents) have been suggested as possible triggers of pemphigus. Occasionally, the disease has been reported to follow viral and bacterial vaccination. We describe a patient who experienced exacerbation of pemphigus shortly after administration of the influenza vaccination on two separate occasions. We review the literature, suggest possible explanations for a causal relationship, and discuss the administration of vaccination to these patients.”

#Dermatological #Influenza #Flu #Pemphigus #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/18681883/

🛑 Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

“After reviewing the literature, we observed that complications seen after Hepatitis B vaccination are sudden infant death syndrome, multiple sclerosis, chronic fatigue syndrome, idiopathic thrombocytopenic purpura, vasculititis optic neuritis, anaphylaxis, systemic lupus erytymatosus, lichen planus and neuro-muscular disorder.”

#Sudden #Infant #Death #Syndrome #SIDS #Hepatitis B #Multiple #Sclerosis #Neurological #Chronic #Fatigue #Syndrome #Lupus #Dermatological #Anaphylaxis #Ophthalmological #Thrombocytopenia
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25506472/

How Contagious Is Vaccinia?

“A report on vaccine-related deaths in the United States during the 1960s found that 12 of the 68 deaths occurred in unvaccinated persons exposed to recently vaccinated family members or friends, a finding that demonstrates the potential gravity of the problem.”

“Numerous reports have described the spread of vaccinia virus within families. The majority are in- stances of single transmission, usually from a re- cently vaccinated child to an unvaccinated younger sibling.22-25 However, two or more secondary cas- es have been reported in at least eight reports of family outbreaks published from 1931 to 198126-33 (Table 2). Many of the reports describe severe, some- times fatal eczema vaccinatum in the first family member with secondary disease and substantially milder local inoculation disease in the rest of the family.”

#Recently #Vaccinated #Shedding #Death #Smallpox #Eczema #Dermatological #Vaccine
#MedScienceResearch

http://www.nejm.org/doi/pdf/10.1056/NEJMra022500

Hypersensitivity reactions to human papillomavirus vaccine in Australian schoolgirls: retrospective cohort study.

“Thirteen (52%) experienced urticaria or angio-oedema, and of these, two experienced anaphylaxis.”

#Gardasil #Anaphylaxis #Dermatological #HPV #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/19050332/

Injection Site Lichenoid Dermatitis Following Pneumococcal Vaccination: Report and Review of Cutaneous Conditions Occurring at Vaccination Sites.

“Basal cell carcinoma and squamous cell carcinoma are the most common vaccination site-associated malignancies; however, melanoma and sarcomas (dermatofibrosarcoma protuberans, fibrosarcoma, and malignant fibrous histiocytoma) are also smallpox vaccine-related site neoplasms.”

#Dermatological #Cancer #Pneumococcal #Smallpox #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/26988991/

Inoculation indeterminate leprosy localised to a smallpox vaccination scar.

“A single, indeterminate leprosy lesion localised exclusively to a smallpox vaccination scar in a 32-year old Indian male is reported. The diagnosis was confirmed by histopathology. This is the second published report of a leprosy lesion occurring at the site of a smallpox vaccination.”

#Leprosy #Smallpox #Dermatological
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/18309715/

Lichenoid Drug Eruption After Human Papillomavirus Vaccination

#HPV #Dermatological #Gardasil
#Vaccine #MedScienceResearch

http://onlinelibrary.wiley.com/doi/10.1111/pde.12516/full

Lupus vulgaris at the site of BCG vaccination: report of three cases.

#Dermatological #BCG #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/19094126/

Malignant change in smallpox vaccination scars.

“Seven cases of patients who had malignant change in smallpox vaccination scars have been previously published. This report is the eighth such case. The patient developed a pigmented basal-cell epithelioma in a vaccination scar 20 years after vaccination. Histological examination revealed a superficial basal-cell epithelioma.”

#Cancer #Smallpox #Dermatological #Vaccine #MedScienceResearch

http://jamanetwork.com/journals/jamadermatology/article-abstract/529615

Malignant Tumors as a Late Complication of Vaccination

“Four basal and one squamous cell carcinomas and a single instance of a malignant melanoma arising in vaccination scars have occurred in five southern California patients. Sun exposure on a previously scarred skin was the main etiological factor in the development of the basal and squamous cell tumors. Sun exposure was probably unimportant in the case of the melanoma because of the short time interval between vaccination and the development of the tumor.”

#Cancer #Smallpox #Dermatological #Vaccine #MedScienceResearch

http://jamanetwork.com/journals/jamadermatology/article-abstract/530688

Natural human infections with Vaccinia virus during bovine vaccinia outbreaks.

“Farmers, milkers and their close contacts developed lesions on the hands, forearms, legs and face accompanied by fever, headache, malaise, myalgia and axillary, inguinal and cervical lymphadenopathy.”

“…and 50% of smallpox-vaccinated individuals developed symptoms.”

#Shedding #Smallpox #Dermatological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/19243990/

Possible Triggering Effect of Influenza Vaccination on Psoriasis.

#Psoriasis #Dermatological #Influenza #Flu #Immune #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/26380315

Progressive vaccinia in a military smallpox vaccinee – United States, 2009.

“Progressive vaccinia (PV), previously known as vaccinia necrosum, vaccinia gangrenosum, or disseminated vaccinia, is a rare, often fatal adverse event after vaccination with smallpox vaccine, which is made from live vaccinia virus. During recent vaccination programs potential cases of PV were investigated, but none met standard case definitions. PV has not been confirmed to have occurred in the United States since 1987. On March 2, 2009, a U.S. Navy Hospital contacted the Poxvirus Program at CDC to report a possible case of PV in a male military smallpox vaccinee. The service member had been newly diagnosed with acute mylegenous leukemia M0 (AML M0). During evaluation for a chemotherapy-induced neutropenic fever, he was found to have an expanding and nonhealing painless vaccination site 6.5 weeks after receipt of smallpox vaccine.”

#Smallpox #Fatal #Vaccinia #Vaccine #Dermatological #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/19478722/

The relationship between vaccine refusal and self-report of atopic disease in children

#Asthma #Allergy #Eczema #Dermatological #Autoimmunity
#MedScienceResearch #Vaccine

http://www.sciencedirect.com/science/article/pii/S0091674905000266

[Scleroderma-like patch on the thigh in infants after vitamin K injection at birth: six observations].

#Vitamin K #Dermatological #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/9615122

Severe eczema vaccinatum in a household contact of a smallpox vaccinee.

“A 28-month-old child with refractory atopic dermatitis developed eczema vaccinatum after exposure to his father, a member of the US military who had recently received smallpox vaccine. The father had a history of inactive eczema but reportedly reacted normally to the vaccine. The child’s mother also developed contact vaccinia infection.”

#Shedding #Eczema #Smallpox #Dermatological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/18419490/

[Squamous cell carcinoma in ulcer after bacille Calmette-Guérin vaccination].

“Marjolin’s ulcer is an aggressive squamous cell carcinoma (SCC) found in chronically inflamed skin. SCC has been reported in smallpox vaccination sites, whereas basal cell carcinomas are more common in scar after bacille Calmette-Guérin (BCG) vaccination. A 72-year-old man presented with a chronic ulcer at the site of his childhood BCG vaccination.”

#Cancer #BCG #Dermatological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/25316362/

Transmission of vaccinia virus, possibly through sexual contact, to a woman at high risk for adverse complications.

“Severe adverse events, including eczema vaccinatum (EV), can result after smallpox vaccination. Persons at risk for EV include those with underlying dermatologic conditions, such as atopic dermatitis. We investigated a case of vaccinia infection, possibly acquired during sexual contact with a recently vaccinated military service member, in a female Maryland resident with atopic dermatitis. The U.S. Department of Defense’s Vaccine Healthcare Centers Network (VHCN) and the Centers for Disease Control and Prevention (CDC) worked in conjunction with the patient’s physician and the Maryland Department of Health and Mental Hygiene (DHMH) to confirm the diagnosis, ensure treatment, and prevent further transmission. Specimens collected from the patient were tested at the DHMH laboratories and were positive by real-time polymerase chain reaction for nonvariola orthopoxvirus. Testing at the CDC verified the presence of vaccinia-specific DNA signatures. Continuing spread of the patient’s lesions led to the administration of vaccinia immune globulin and strict infection control measures to prevent tertiary transmission to vulnerable family members, also with atopic dermatitis. VHCN contacted the service member to reinforce vaccination site care and hygiene. This case underscores the importance of prevaccination education for those receiving the smallpox vaccine to protect contacts at risk for developing severe adverse reactions.”

#Shedding #Smallpox #Genital #Sexual #Transmission #Eczema #Dermatological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/24306023/

Ulcerated Giant Dermatofibroma following Routine Childhood Vaccination in a Young Boy.

#Dermatological #Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/27721753/

Widespread eczema vaccinatum acquired by contacts. A report of an autopsy case

“A 4-month-old male infant predisposed to allergic dermatitis acquired wide-spread eczema vaccinatum by contacts with a recently vaccinated sibling. He died of acute purulent peritonitis following a perforation of multiple duodenal ulcers. Fluorescence immunocytochemical and electron microscopic studies on the skin lesions revealed the presence of viral antigens and numerous virus particles compatible morphologically with those of the mature form from the same batch of smallpox vaccine given to the sibling. A large number of virus particles in the developmental form were also predominantly scattered in the cytoplasm of cells at the stratum malpighii of the epidermis as well as in neutrophils and macrophages in the skin lesions. The virus isolation from the skin lesions was done by using the HeLa cells and the human embryonic lung fibroblasts. No abnormal laboratory data were noted in immunoglobulins. On the basis of atrophy of the thymus and other lymphatic tissues and an appearance of large pyroninophilic cells in association with blastoid transformation, the authors discussed a possible participation of the disturbance of cellular immunity secondary to the virus infection in the development of the disease.”

#Death #Shedding #Smallpox #Eczema #Vaccine #Dermatological
#MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/377910/