Gardasil

“Opsoclonus-Myoclonus Syndrome (OMS) is a rare neurologic condition comprised of the two hallmark signs of dysmetric ocular ataxia and myoclonic jerks of the extremities. The eye movements have been described as “dancing eyes”. The eyes dart involuntarily away from the point of visual fixation or pursuit in a manner that can be considered a myoclonic jerk of the extra-ocular muscles. When the patient attempts to align the gaze on a point, there may be dysmetric overshoot of the eye movement. Myoclonic movements of the extremities occur at rest, and intended actions are ataxic. The mean age of presentation of OMS in childhood is 14 months, and it presents as a paraneoplastic syndrome associated with an underlying tumor in 50–60% of the cases [1,2], most commonly neuroblastoma or ganglioneuroblastoma. Recent research has revealed the presence of several auto-antibodies including anti-Hu, anti-Ri, α-Enolase, KSRP and NLK [3] in patients with OMS. These antibodies bind to an array of targets in the cerebellum and may manifest as oligoclonal bands in cerebrospinal fluid. The syndrome is often associated with behavioral changes such as aggression, irritability, and insomnia. Post-vaccine OMS is not well described in the pediatric population. The patient was a fully vaccinated and developmentally appropriate 11-year-old female with seasonal allergies and mild asthma. Her initial symptoms consisted of a sudden onset of increased “moodiness” causing uncharacteristic anger and depression. These symptoms presented approximately 15 days after receiving her first human papilloma virus (HPV) (Gardisil®) vaccination on 11/26/2007. The uncharacteristic behavior persisted and 1 month after the initial mood changes she noted that her “eyes were doing weird things” and she perceived that visual images went “back and forth in circles”. The abnormal ocular movements occurred with her eyes closed or open, and could be only minimally suppressed with great effort. There were no other symptoms at this time, however, her eye symptoms became more frequent and troubling to her. She then received a second HPV vaccination 2 months later in addition to a meningococcal (Menactra®) vaccine. Four days after these vaccinations she developed noticeable worsening of the eye movements and acute perception of dizziness, which she described as the “room is spinning.” This was accompanied by leg weakness requiring assistance to walk and “jumpy arms.” Family history reveals a cousin with childhood epilepsy, maternal great aunt with lupus, maternal grandfather died of a ruptured aneurysm at age 40, and mother with fibromyalgia, but no movement disorders or paraneoplastic syndromes. There is one case report of post-vaccine OMS in a 30-year-old female with an allergic diathesis [4]. Her symptoms began two weeks after a vaccine. She failed to improve with corticosteroid therapy, but IVIG was not used. She derived clinical benefit from benzodiazepines and her symptoms resolved completely within 10 months.”

#Gardasil #Neurological #HPV
#Ophthalmological #Eyes #Ataxia #Psychiatric #Meningococcal
#Vaccine #MedScienceResearch

https://www.ncbi.nlm.nih.gov/m/pubmed/19447066/

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Orthostatic intolerance and postural tachycardia syndrome as suspected adverse effects of vaccination against human papilloma virus.