Eczema
Eczema vaccinatum resulting from the transmission of vaccinia virus from a smallpox vaccinee: an investigation of potential fomites in the home environment.
“On March 3, 2007, a 2-year-old boy was hospitalized with eczema vaccinatum. His two siblings, one with eczema, were subsequently removed from the home. Swabs of household items obtained on March 13th were analyzed for orthopoxvirus DNA signatures with real-time PCR. Virus culture was attempted on positive specimens. Eight of 25 household samples were positive by PCR for orthopoxvirus; of these, three yielded viable vaccinia virus in culture. Both siblings were found to have serologic evidence of orthopoxvirus exposure.”
#Shedding #Eczema #Smallpox #Dermatological #Vaccine #MedScienceResearch
https://www.ncbi.nlm.nih.gov/m/pubmed/19027813/
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How Contagious Is Vaccinia?
“A report on vaccine-related deaths in the United States during the 1960s found that 12 of the 68 deaths occurred in unvaccinated persons exposed to recently vaccinated family members or friends, a finding that demonstrates the potential gravity of the problem.”
“Numerous reports have described the spread of vaccinia virus within families. The majority are in- stances of single transmission, usually from a re- cently vaccinated child to an unvaccinated younger sibling.22-25 However, two or more secondary cas- es have been reported in at least eight reports of family outbreaks published from 1931 to 198126-33 (Table 2). Many of the reports describe severe, some- times fatal eczema vaccinatum in the first family member with secondary disease and substantially milder local inoculation disease in the rest of the family.”
#Recently #Vaccinated #Shedding #Death #Smallpox #Eczema #Dermatological #Vaccine
#MedScienceResearch
http://www.nejm.org/doi/pdf/10.1056/NEJMra022500
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The relationship between vaccine refusal and self-report of atopic disease in children
#Asthma #Allergy #Eczema #Dermatological #Autoimmunity
#MedScienceResearch #Vaccine
http://www.sciencedirect.com/science/article/pii/S0091674905000266
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Severe eczema vaccinatum in a household contact of a smallpox vaccinee.
“A 28-month-old child with refractory atopic dermatitis developed eczema vaccinatum after exposure to his father, a member of the US military who had recently received smallpox vaccine. The father had a history of inactive eczema but reportedly reacted normally to the vaccine. The child’s mother also developed contact vaccinia infection.”
#Shedding #Eczema #Smallpox #Dermatological #Vaccine #MedScienceResearch
https://www.ncbi.nlm.nih.gov/m/pubmed/18419490/
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Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age.
“…however, children with delayed DTaP had less eczema and less use of eczema medication. Timing of routine infant immunizations may affect susceptibility to allergic disease.”
#Eczema #DTaP #Autoimmunity #Vaccine #MedScienceResearch
https://www.ncbi.nlm.nih.gov/m/pubmed/26707796/
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Transmission of vaccinia virus, possibly through sexual contact, to a woman at high risk for adverse complications.
“Severe adverse events, including eczema vaccinatum (EV), can result after smallpox vaccination. Persons at risk for EV include those with underlying dermatologic conditions, such as atopic dermatitis. We investigated a case of vaccinia infection, possibly acquired during sexual contact with a recently vaccinated military service member, in a female Maryland resident with atopic dermatitis. The U.S. Department of Defense’s Vaccine Healthcare Centers Network (VHCN) and the Centers for Disease Control and Prevention (CDC) worked in conjunction with the patient’s physician and the Maryland Department of Health and Mental Hygiene (DHMH) to confirm the diagnosis, ensure treatment, and prevent further transmission. Specimens collected from the patient were tested at the DHMH laboratories and were positive by real-time polymerase chain reaction for nonvariola orthopoxvirus. Testing at the CDC verified the presence of vaccinia-specific DNA signatures. Continuing spread of the patient’s lesions led to the administration of vaccinia immune globulin and strict infection control measures to prevent tertiary transmission to vulnerable family members, also with atopic dermatitis. VHCN contacted the service member to reinforce vaccination site care and hygiene. This case underscores the importance of prevaccination education for those receiving the smallpox vaccine to protect contacts at risk for developing severe adverse reactions.”
#Shedding #Smallpox #Genital #Sexual #Transmission #Eczema #Dermatological #Vaccine #MedScienceResearch
https://www.ncbi.nlm.nih.gov/m/pubmed/24306023/
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Widespread eczema vaccinatum acquired by contacts. A report of an autopsy case
“A 4-month-old male infant predisposed to allergic dermatitis acquired wide-spread eczema vaccinatum by contacts with a recently vaccinated sibling. He died of acute purulent peritonitis following a perforation of multiple duodenal ulcers. Fluorescence immunocytochemical and electron microscopic studies on the skin lesions revealed the presence of viral antigens and numerous virus particles compatible morphologically with those of the mature form from the same batch of smallpox vaccine given to the sibling. A large number of virus particles in the developmental form were also predominantly scattered in the cytoplasm of cells at the stratum malpighii of the epidermis as well as in neutrophils and macrophages in the skin lesions. The virus isolation from the skin lesions was done by using the HeLa cells and the human embryonic lung fibroblasts. No abnormal laboratory data were noted in immunoglobulins. On the basis of atrophy of the thymus and other lymphatic tissues and an appearance of large pyroninophilic cells in association with blastoid transformation, the authors discussed a possible participation of the disturbance of cellular immunity secondary to the virus infection in the development of the disease.”
#Death #Shedding #Smallpox #Eczema #Vaccine #Dermatological
#MedScienceResearch
