Adjuvants- and vaccines-induced autoimmunity: animal models.
“In some cases, adjuvants may trigger generalized autoimmune response, resulting in multiple auto-antibodies, but sometimes they can reproduce human autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, autoimmune thyroiditis and antiphospholipid syndrome and may provide insights about the potential adverse effects of adjuvants.”
? Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity.
[Differential diagnosis of thyrotoxicosis in subjects with post-immunization reaction].
“An increasingly greater fraction of the general population is getting involved in the immunization program. However, conditions of individual subjects are not always properly evaluated prior to immunization. The clinical case reported below demonstrates the difficulty of diagnostic examination of patients with Graves disease (toxic goiter), endocrine ophthalmopathy, and post-immunization reaction.”
Lymphoid thyroiditis following immunization with group A streptococcal vaccine.
? [Lymphoma of the thyroid in a patient with autoimmune thyroiditis and Sjögren’s syndrome–case report].
“As many years of immunisation may lead to carcinogenesis it is important to raise awareness among medical staff with regard to cases of chronic autoimmune disease.”
Subacute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation.
Subacute thyroiditis (de Quervain’s) due to influenza A: presenting as fever of unknown origin (FUO).
“Influenza immunization or infection may cause subacute thyroiditis.”
Subacute thyroiditis following influenza vaccine (Vaxigrip) in a young female.
Subacute thyroiditis following seasonal influenza vaccination.
? An unmasking phenomenon in an observational post-licensure safety study of adolescent girls and young women.
“Our recent experience in a post-licensure safety study of autoimmune conditions following the quadrivalent human papillomavirus vaccine in 189,629 girls and young women ages 9-26 years led us to question the adequacy of the exclusion of Day 0 events to prevent the erroneous association of prevalent conditions with vaccination. Of the 18 confirmed cases of Graves’ disease diagnosed in days 1-60 following vaccination, only 6 cases appeared to be truly new onset. Among the remaining 12 cases, 2 cases had abnormal thyroid stimulating hormone or thyroxine labs drawn prior to or on Day 0 but had no documented pre-existing symptoms. The other 10 cases had mention of symptoms of hyperthyroidism referencing a period prior to first HPV-4 dose. This ‘unmasking’ phenomenon, due to health care visits that include vaccination and new workups of preexisting symptoms, may not be adequately controlled through the exclusion of Day 0 events.”